Výsledky vyhledávání - "Shaun Langdon"

Anti-SARS-CoV-2 IgA Identifies Asymptomatic Infection in First Responders

Autor: Eric A. F. Simões, Femi Elemo, Andrea T. Hooper, Rowena Crow, Brian T. Montague, Jennifer D. Hamilton, Matthew F. Wipperman, Shaun Langdon, Lisa Hersh, Sara Hamon, Meagan P. O'Brien

Publikováno v: The Journal of Infectious Diseases

Background Immunoglobulin A (IgA) is an important component of the early immune response to SARS-CoV-2. Prior serosurveys in high-risk groups employing IgG testing alone have provided discordant estimates. The potential added benefit of IgA in serosu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5a7ef599d624060e3fdfa2a7d11dd6c
https://doi.org/10.1093/infdis/jiab524

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Biochemical and behavioral effects of PDE10A inhibitors: Relationship to target site occupancy

Autor: Nicholas J. Lodge, John E. Macor, Matthew A. Seager, Samuel Gerritz, Shaun Langdon, Robert Zaczek, Joanne J. Bronson, Alda Fernandes, Karen Heman, James R. Merritt, Yuan Tian, Ryan Westphal, Yang Hong, Annapurna Pendri, Lizbeth Gallagher, Trevor Wojcik, Chongwu Zhang, Yu-Wen Li, Thaddeus F. Molski

Publikováno v: Neuropharmacology. 102:121-135

Phosphodiesterase 10A (PDE10A) inhibitors increase the functionality of striatal medium spiny neurons and produce antipsychotic-like effects in rodents by blocking PDE10A mediated hydrolysis of cAMP and/or cGMP. In the current study, we characterized

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b50ec40816a7742dc7b4e4a7ab5b0fdb
https://doi.org/10.1016/j.neuropharm.2015.10.037

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Monoamine reuptake site occupancy of sibutramine: Relationship to antidepressant-like and thermogenic effects in rats

Autor: Kenneth W. Rohrbach, Snjezana Lelas, Yu-Wen Li, Todd Strong, Nicholas J. Lodge, Robert N. Wright, Rick L. Pieschl, Shaun Langdon

Publikováno v: European Journal of Pharmacology. 737:47-56

Sibutramine was formerly marketed as an anti-obesity agent. The current study investigated the relationships between monoamine reuptake site occupancy for sibutramine and both its antidepressant-like efficacy and thermogenic effects. Sibutramine’s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ec6005884d49ac8713914e4f162bd1b
https://doi.org/10.1016/j.ejphar.2014.03.024

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Colorectal distension-induced pseudoaffective changes as indices of nociception in the anesthetized female rat: Morphine and strain effects on visceral sensitivity

Autor: Nicholas J. Lodge, Christopher Bernard, Digavalli V. Sivarao, Shaun Langdon

Publikováno v: Journal of Pharmacological and Toxicological Methods. 56:43-50

Introduction Colorectal distension of a sufficient intensity evokes several characteristic postural, visceromotor and cardiovascular reflexes in conscious rats that have been extensively utilized for testing putative visceral analgesics. The neural c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea4622b5822a58752411af7aa08b15a6
https://doi.org/10.1016/j.vascn.2006.12.004

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Effect of 4-(5-Chloro-2-hydroxyphenyl)-3-(2-hydroxyethyl)-6-(trifluoromethyl)-quinolin-2(1H)-one (BMS-223131), a Novel Opener of Large Conductance Ca2+-Activated K+ (Maxi-K) Channels on Normal and Stress-Aggravated Colonic Motility and Visceral Nociception

Autor: Piyasena Hewawasam, Robert A. Myers, Nicholas J. Lodge, Kimberly Newberry, Shaun Langdon, Alicia V. Lee, Digavalli V. Sivarao, Laura J. Signor, Mary Jane Plym

Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 313:840-847

We evaluated the effects of 4-(5-chloro-2-hydroxyphenyl)-3-(2-hydroxyethyl)-6-(trifluoromethyl)-quinolin-2(1H)-one (BMS-223131), an opener of large conductance Ca(2+)-activated potassium (maxi-K) channels, on normal and stress-exacerbated colonic mot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6b8a9a219eafe737e533d6c78c27fc68
https://doi.org/10.1124/jpet.104.079285

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Effect of 4-(5-chloro-2-hydroxyphenyl)-3-(2-hydroxyethyl)-6-(trifluoromethyl)-quinolin-2(1H)-one (BMS-223131), a novel opener of large conductance Ca2+-activated K+ (maxi-K) channels on normal and stress-aggravated colonic motility and visceral nociception

Autor: Digavalli V, Sivarao, Kimberly, Newberry, Shaun, Langdon, Alicia V, Lee, Piyasena, Hewawasam, Mary Jane, Plym, Laura, Signor, Robert, Myers, Nicholas J, Lodge

Publikováno v: The Journal of pharmacology and experimental therapeutics. 313(2)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e3ec5df3022e9fdddfb324abdebbc2c3
https://pubmed.ncbi.nlm.nih.gov/15701710

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