Výsledky vyhledávání - "Shaun L, Sandow"

Akademický článek

Editorial: The role of pericytes in physiology and pathophysiology

Autor: Shaun L. Sandow, Sean M. Wilson, M. Dennis Leo

Publikováno v: Frontiers in Physiology, Vol 14 (2023)

Externí odkaz: https://doaj.org/article/618a1e08be83409fa6ff87e0e4ef8016

Akademický článek

Neurovascular Uncoupling Is Linked to Microcirculatory Dysfunction in Regions Outside the Ischemic Core Following Ischemic Stroke

Autor: Christian Staehr, John T. Giblin, Eugenio Gutiérrez‐Jiménez, Halvor Ø. Guldbrandsen, Jianbo Tang, Shaun L. Sandow, David A. Boas, Vladimir V. Matchkov

Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 12, Iss 11 (2023)

Background Normal brain function depends on the ability of the vasculature to increase blood flow to regions with high metabolic demands. Impaired neurovascular coupling, such as the local hyperemic response to neuronal activity, may contribute to po

Externí odkaz: https://doaj.org/article/6654ca74a473490f8c641ed8f0da8511

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Akademický článek

KV7 Channel Expression and Function Within Rat Mesenteric Endothelial Cells

Autor: Samuel N. Baldwin, Shaun L. Sandow, Gema Mondéjar-Parreño, Jennifer B. Stott, Iain A. Greenwood

Publikováno v: Frontiers in Physiology, Vol 11 (2020)

Background and Purpose: Arterial diameter is dictated by the contractile state of the vascular smooth muscle cells (VSMCs), which is modulated by direct and indirect inputs from endothelial cells (ECs). Modulators of KCNQ-encoded kV7 channels have co

Externí odkaz: https://doaj.org/article/bd48e0b6c26a464081470627100df2e6

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Akademický článek

Blockade of Pannexin-1 Channels and Purinergic P2X7 Receptors Shows Protective Effects Against Cytokines-Induced Colitis of Human Colonic Mucosa

Autor: Erica F. Diezmos, Irit Markus, D. S. Perera, Steven Gan, Li Zhang, Shaun L. Sandow, Paul P. Bertrand, Lu Liu

Publikováno v: Frontiers in Pharmacology, Vol 9 (2018)

Introduction: The pannexin-1 (Panx1) channels are found in many cell types, and ATP released from these channels can act on nearby cells activating purinergic P2X7 receptors (P2X7R) which lead to inflammation. Although Panx1 and P2X7R are implicated

Externí odkaz: https://doaj.org/article/b5778ad81fb34d5f8a795c06103f006b

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Microcirculatory dysfunction associates with neurovascular uncoupling in peri-ischemic brain regions after ischemic stroke

Autor: Christian Staehr, John T. Giblin, Eugenio Gutiérrez-Jiménez, Halvor Guldbrandsen, Jianbo Tang, Shaun L. Sandow, David A. Boas, Vladimir V. Matchkov

BackgroundDespite recanalization after ischemic stroke, neurovascular coupling, i.e., the local hyperaemic response to neuronal activity, is impaired in peri-ischemic brain regions. Reduced neurovascular coupling may contribute to neurological deteri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d86f4ff765a64e7b01ae37841492f606
https://doi.org/10.1101/2022.08.26.505245

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Effect of β 1 /β 2 ‐adrenoceptor blockade on β 3 ‐adrenoceptor activity in the rat cremaster muscle artery

Autor: Shaun L. Sandow, Irit Markus, Dana S. Hutchinson, Fiona C. Britton, Samantha L. Saunders, Timothy V. Murphy, Lu Liu

Publikováno v: British Journal of Pharmacology. 178:1789-1804

BACKGROUND AND PURPOSE The physiological role of vascular β3 -adrenoceptors is not fully understood. Recent evidence suggests cardiac β3 -adrenoceptors are functionally effective after down-regulation of β1 /β2 -adrenoceptors. The functional inte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f7bc0c1927f1cccad5781ca3762a4c43
https://doi.org/10.1111/bph.15398

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