Toll-like Receptor 2 Is Essential for the Sensing of Oxidants during Inflammation

Autor: Mark J. Paul-Clark, Jane Mitchell, Bernhard Ryffel, Shiranee Sriskandan, Valérie F. J. Quesniaux, Laura Moreno, Lucy Bailey, Rosalinda Sorrentino, Shaun K. McMaster

Publikováno v: American Journal of Respiratory and Critical Care Medicine
American Journal of Respiratory and Critical Care Medicine, American Thoracic Society, 2009, 179 (4), pp.299-306. ⟨10.1164/rccm.200707-1019OC⟩

International audience; RATIONALE: The mechanisms by which oxidants are sensed by cells and cause inflammation are not well understood. OBJECTIVES: This study aimed to determine how cells "sense" soluble oxidants and how this is translated into an in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68b22510c22415a32158f2f0c65c36ad
https://doi.org/10.1164/rccm.200707-1019oc

COX-1, and not COX-2 activity, regulates airway function: relevance to aspirin-sensitive asthma

Autor: Jane A. Mitchell, Ruth Lucas, Timothy D. Warner, Shaun K. McMaster, Glenis Scadding, Louise S. Harrington, Laura Moreno

Publikováno v: The FASEB Journal

Cyclooxygenase (COX) -1 and COX-2 are expressed in airway cells, where their activities influence functions such as airway hyperreactivity. Clinical data show that mixed COX-1/COX-2 inhibitors such as aspirin, but not COX-2 selective inhibitors such

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2aadf0ff431a47b1434893d2aab1b297
http://europepmc.org/articles/PMC2691413

ELUCIDATION OF TOLL-LIKE RECEPTOR AND ADAPTER PROTEIN SIGNALING IN VASCULAR DYSFUNCTION INDUCED BY GRAM-POSITIVE STAPHYLOCOCCUS AUREUS OR GRAM-NEGATIVE ESCHERICHIA COLI

Autor: Valérie F. J. Quesniaux, Mark J. Paul-Clark, Shaun K. McMaster, Rosalinda Sorrentino, Shiranee Sriskandan, Jane A. Mitchell, Timothy W. Evans, Neil Cartwright, Bernhard Ryffel

Publikováno v: Shock
Shock, Lippincott, Williams & Wilkins, 2007, 27 (1), pp.40-7. ⟨10.1097/01.shk.0000235127.59492.db⟩

Pathogens contain specific pathogen-associated molecular patterns, which activate pattern recognition receptors of the innate immune system such as Toll-like receptors (TLRs). Although there is a clear evidence of how macrophages sense pathogens, we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fb9c94befc790aba90598724cd1134e
https://doi.org/10.1097/01.shk.0000235127.59492.db

Selective NOD1 agonists cause shock and organ injury/dysfunction in vivo

Autor: Bernhard Ryffel, Timothy W. Evans, Neil Cartwright, Mark J. Paul-Clark, Christoph Thiemermann, David A. van Heel, Jane A. Mitchell, Oliver Murch, Shaun K. McMaster, Valérie F. J. Quesniaux

Publikováno v: American Journal of Respiratory and Critical Care Medicine
American Journal of Respiratory and Critical Care Medicine, American Thoracic Society, 2007, 175 (6), pp.595-603. ⟨10.1164/rccm.200608-1103OC⟩

RATIONALE: NLRs (nucleotide oligomerisation domain [NOD] proteins containing a leucine-rich repeat) are cytosolic pattern recognition receptors. NOD1 senses diaminopimelic acid-containing peptidoglycan present in gram-negative bacteria, whereas NOD2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::886702b51dfe625844028e13d9c65ed4
https://hal.archives-ouvertes.fr/hal-00318481

Cigarette smoke activates human monocytes by an oxidant-AP-1 signaling pathway: implications for steroid resistance

Autor: Shaun K. McMaster, Kazuhiro Ito, Jane A. Mitchell, Matthew J. Walters, Ian M. Adcock, Mark J. Paul-Clark

Publikováno v: Molecular pharmacology. 68(5)

Smoking cigarettes is a major risk factor for the development of cardiovascular and respiratory disease. Moreover, smoking-induced pathophysiology is often resistant to the anti-inflammatory effects of glucocorticoids. The nature of cigarette smoke-i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54a19a7816c64961855a02c905248a73
https://pubmed.ncbi.nlm.nih.gov/16061772