Výsledky vyhledávání - "Shaun K. Mc Master"

Differential effects of Gram-positive versus Gram-negative bacteria on NOSII and TNFα in macrophages: role of TLRs in synergy between the two

Autor: Jasmine Anandarajah, Mark Fleet, Elizabeth Belcher, Mark J. Paul-Clark, Shiranee Sriskandan, Jane A. Mitchell, Rosalinda Sorrentino, Shaun K. Mc Master

Publikováno v: British Journal of Pharmacology. 148:1067-1075

Gram-negative and Gram-positive bacteria are sensed by Toll-like receptor (TLR)4 and TLR2, respectively. TLR4 recruits MyD88 and TRIF, whereas TLR2 recruits MyD88 without TRIF. NOSII and TNFα are central genes in innate immunity and are thought to b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::eeecf6e92213d54b544c1dde5b4529cc
https://doi.org/10.1038/sj.bjp.0706815

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Synergistic induction of endothelin-1 by tumor necrosis factor alpha and interferon gamma is due to enhanced NF-kappaB binding and histone acetylation at specific kappaB sites

Autor: Ian M. Adcock, Misako Ito, Shaun K. Mc Master, Elen Jazrawi, Stephen J. Wort, Pai Chien Chou, Timothy W. Evans, Jane Mitchell, Rekha Badiger, Patricia M. De Souza, K. Ito, Liao Pinhu

Publikováno v: The Journal of biological chemistry. 284(36)

Endothelin-1 (ET-1) is a potent vasoconstrictor and co-mitogen for vascular smooth muscle and is implicated in pulmonary vascular remodeling and the development of pulmonary arterial hypertension. Vascular smooth muscle is an important source of ET-1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1978ff72cda896a87216c22fd9bdea83
https://pubmed.ncbi.nlm.nih.gov/19592490

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