Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Shaun H, Speldewinde"'
Autor:
Shaun H. Speldewinde, Chris M. Grant
Publikováno v:
Microbial Cell, Vol 4, Iss 4, Pp 127-132 (2017)
Ageing involves a time-dependent decline in a variety of intracellular mechanisms and is associated with cellular senescence. This can be exacerbated by prion diseases which can occur in a sporadic manner, predominantly during the later stages of lif
Externí odkaz:
https://doaj.org/article/8c0be892dee94ae89c11cb2785cafcb6
Publikováno v:
PLoS Genetics, Vol 13, Iss 4, p e1006708 (2017)
Mammalian and fungal prions arise de novo; however, the mechanism is poorly understood in molecular terms. One strong possibility is that oxidative damage to the non-prion form of a protein may be an important trigger influencing the formation of its
Externí odkaz:
https://doaj.org/article/e13b63ac85914d3db2c3cd4b7bb4a1c5
Autor:
Shaun H. Speldewinde, Chris M. Grant
Publikováno v:
Microbial Cell, Vol 3, Iss 1, Pp 46-48 (2015)
Prions are self-perpetuating amyloid protein aggregates which underlie various neurodegenerative diseases in mammals. The molecular basis underlying their conversion from a normally soluble protein into the prion form remains largely unknown. Studies
Externí odkaz:
https://doaj.org/article/afab122279a34da4a3e71b444046a55b
Publikováno v:
Molecular Cell
Summary Translating ribosomes that slow excessively incur collisions with trailing ribosomes. Persistent collisions are detected by ZNF598, a ubiquitin ligase that ubiquitinates sites on the ribosomal 40S subunit to initiate pathways of mRNA and prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45a91e1fcb6fbb197854c08f4d4cbab9
Autor:
Shaun H. Speldewinde, Chris M. Grant
Publikováno v:
Microbial Cell
Molecular Biology of the Cell
Microbial Cell, Vol 3, Iss 1, Pp 46-48 (2015)
Molecular Biology of the Cell
Microbial Cell, Vol 3, Iss 1, Pp 46-48 (2015)
The molecular basis by which prions arise spontaneously is poorly understood. The present data point toward oxidative protein damage as one of the triggers of de novo prion formation. Autophagy functions to clear oxidatively damaged proteins before t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48402dc55b0aafdc80c00b32ae2417cd
http://europepmc.org/articles/PMC5354589
http://europepmc.org/articles/PMC5354589
Autor:
Victoria A, Doronina, Gemma L, Staniforth, Shaun H, Speldewinde, Mick F, Tuite, Chris M, Grant
Publikováno v:
Molecular Microbiology
Summary Prions are self‐perpetuating amyloid protein aggregates which underlie various neurodegenerative diseases in mammals and heritable traits in yeast. The molecular basis of how yeast and mammalian prions form spontaneously into infectious amy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c3c541d961bdd426e393ddce62355d23
https://pubmed.ncbi.nlm.nih.gov/25601439
https://pubmed.ncbi.nlm.nih.gov/25601439