Výsledky vyhledávání - "Shaun D. Wong"

Nuclear Resonance Vibrational Spectroscopic Definition of the Facial Triad FeIV═O Intermediate in Taurine Dioxygenase: Evaluation of Structural Contributions to Hydrogen Atom Abstraction

Autor: Shyam R. Iyer, Shaun D. Wong, Edward I. Solomon, Martin Srnec, Makina Saito, Kyle D. Sutherlin, Kiyoung Park, Laura M. K. Dassama, Makoto Seto, J. Martin Bollinger, Yasuhiro Kobayashi, Yoshitaka Yoda, Carsten Krebs, Masayuki Kurokuzu

Publikováno v: Journal of the American Chemical Society. 142:18886-18896

The α-ketoglutarate (αKG)-dependent oxygenases catalyze a diverse range of chemical reactions using a common high-spin FeIV═O intermediate that, in most reactions, abstract a hydrogen atom from the substrate. Previously, the FeIV═O intermediate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::85ae0cf250db39b49b0deb3f445011a0
https://doi.org/10.1021/jacs.0c08903

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Nuclear Resonance Vibrational Spectroscopic Definition of the Facial Triad Fe

Autor: Martin, Srnec, Shyam R, Iyer, Laura M K, Dassama, Kiyoung, Park, Shaun D, Wong, Kyle D, Sutherlin, Yoshitaka, Yoda, Yasuhiro, Kobayashi, Masayuki, Kurokuzu, Makina, Saito, Makoto, Seto, Carsten, Krebs, J Martin, Bollinger, Edward I, Solomon

Publikováno v: J Am Chem Soc

The α-ketoglutarate (αKG)-dependent oxygenases catalyze a diverse range of chemical reactions using a common high-spin Fe(IV)=O intermediate and, in most reactions, abstracts a hydrogen atom from the substrate. Previously, the Fe(IV)=O intermediate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1bf39c10aa7803653e345d1c286bc6cc
https://pubmed.ncbi.nlm.nih.gov/33103886

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Peroxide Activation for Electrophilic Reactivity by the Binuclear Non-heme Iron Enzyme AurF

Autor: Shinji Kitao, Yeonju Kwak, Martin Srnec, Michael Hu, Shaun D. Wong, J. Martin Bollinger, Kiyoung Park, Lei V. Liu, Caleb B. Bell, Jiyong Zhao, Edward I. Solomon, Makoto Seto, Ning Li, Carsten Krebs, Yoshitaka Yoda

Publikováno v: Journal of the American Chemical Society. 139:7062-7070

Binuclear non-heme iron enzymes activate O2 for diverse chemistries that include oxygenation of organic substrates and hydrogen atom abstraction. This process often involves the formation of peroxo-bridged biferric intermediates, only some of which c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31cc805ff73ca74a5c70d008d8bd9dde
https://doi.org/10.1021/jacs.7b02997

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Electronic Structure of the Ferryl Intermediate in the α-Ketoglutarate Dependent Non-Heme Iron Halogenase SyrB2: Contributions to H Atom Abstraction Reactivity

Autor: Megan L. Matthews, J. Martin Bollinger, Martin Srnec, Shaun D. Wong, Edward I. Solomon, Carsten Krebs

Publikováno v: Journal of the American Chemical Society. 138:5110-5122

Low temperature magnetic circular dichroism (LT MCD) spectroscopy in combination with quantum-chemical calculations are used to define the electronic structure associated with the geometric structure of the Fe(IV)═O intermediate in SyrB2 that was p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d500d0e85997b78e616103269f943f1
https://doi.org/10.1021/jacs.6b01151

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Spectroscopic and computational insight into the activation of O 2 by the mononuclear Cu center in polysaccharide monooxygenases

Autor: Britt Hedman, Keith O. Hodgson, Edward I. Solomon, Daniel J. Walton, Glyn R. Hemsworth, Feng Xu, Nigel A. Young, Katja Salomon Johansen, Christian H. Kjaergaard, Shaun D. Wong, Gideon J. Davies, Munzarin F. Qayyum, Paul H. Walton

Publikováno v: Proceedings of the National Academy of Sciences. 111:8797-8802

Strategies for O2 activation by copper enzymes were recently expanded to include mononuclear Cu sites, with the discovery of the copper-dependent polysaccharide monooxygenases, also classified as auxiliary-activity enzymes 9-11 (AA9-11). These enzyme

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86e3231589bbc1730dc44b5032423c73
https://doi.org/10.1073/pnas.1408115111

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Excited state potential energy surfaces and their interactions in FeIVO active sites

Autor: Martin Srnec, Edward I. Solomon, Shaun D. Wong

Publikováno v: Dalton Trans.. 43:17567-17577

The non-heme ferryl active sites are of significant interest for their application in biomedical and green catalysis. These sites have been shown to have an S = 1 or S = 2 ground spin state; the latter is functional in biology. Low-temperature magnet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91388c2c90cbb5e7c6fc9e37fc77f231
https://doi.org/10.1039/c4dt01366b

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Elucidation of the Fe(iv)=O intermediate in the catalytic cycle of the halogenase SyrB2

Autor: Shinji Kitao, J. Martin Bollinger, Lei V. Liu, E. Ercan Alp, Caleb B. Bell, Yoshitaka Yoda, Jiyong Zhao, Megan L. Matthews, Carsten Krebs, Kiyoung Park, Edward I. Solomon, Makoto Seto, Yeonju Kwak, Martin Srnec, Shaun D. Wong

Publikováno v: Nature. 499:320-323

Mononuclear non-haem iron (NHFe) enzymes catalyse a broad range of oxidative reactions, including halogenation, hydroxylation, ring closure, desaturation and aromatic ring cleavage reactions. They are involved in a number of biological processes, inc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::599cb5dae0d9861c73a1539a39c12109
https://doi.org/10.1038/nature12304

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Nuclear Resonance Vibrational Spectroscopy on the FeIVO S=2 Non-Heme Site in TMG3tren: Experimentally Calibrated Insights into Reactivity

Autor: Shaun D. Wong, Jiyong Zhao, Lawrence Que, Caleb B. Bell, E. Ercan Alp, Yeonju Kwak, Jason England, Edward I. Solomon, Lei V. Liu

Publikováno v: Angewandte Chemie. 123:3273-3276

Mononuclear non-heme iron (NHFe) enzymes catalyze a number of key biological reactions including hydroxylation, desaturation, ring closure and halogenation.[1-3] The reactive intermediate that carries out many of the C–H bond activations is an S =

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c532d19c6bf05f0fd4ad7079942b508
https://doi.org/10.1002/ange.201007692

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Definition of the intermediates and mechanism of the anticancer drug bleomycin using nuclear resonance vibrational spectroscopy and related methods

Autor: Edward I. Solomon, Jiyong Zhao, Yeonju Kwak, Samuel A. Wilson, Lei V. Liu, Caleb B. Bell, Shaun D. Wong, Keith O. Hodgson, Britt Hedman, Marina S. Chow

Publikováno v: Proceedings of the National Academy of Sciences. 107:22419-22424

Bleomycin (BLM) is a glycopeptide anticancer drug capable of effecting single- and double-strand DNA cleavage. The last detectable intermediate prior to DNA cleavage is a low spin Fe III peroxy level species, termed activated bleomycin (ABLM). DNA st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e47ec4dc1ff23350c8ad1a05752d1e7
https://doi.org/10.1073/pnas.1016323107

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