Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Shaun D, Abbott"'
Autor:
Dr. Boulos Zacharie, Dr. Shaun D. Abbott, Jean‐Simon Duceppe, Dr. Lyne Gagnon, Dr. Brigitte Grouix, Lilianne Geerts, Liette Gervais, François Sarra‐Bournet, Valérie Perron, Dr. Nicole Wilb, Dr. Christopher L. Penney, Pierre Laurin
Publikováno v:
ChemistryOpen, Vol 7, Iss 9, Pp 737-749 (2018)
Abstract Low‐molecular‐weight synthetic molecules 1 with the general 2‐(fluorophenylamino)‐4,6‐disubstituted 1,3,5‐triazine structure and showing anti‐inflammatory and anticancer activities were explored. Structure–activity relationsh
Externí odkaz:
https://doaj.org/article/d79c7adaeef745be869e6e9c100908b6
Publikováno v:
European Journal of Organic Chemistry. 2019:7389-7393
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1669992c85675811318a304ef9b1c6ec
https://doi.org/10.1002/ejoc.201901239
https://doi.org/10.1002/ejoc.201901239
Autor:
Jugurtha Ouboudinar, Ramon Corpuz, Martin Leduc, Jean-Simon Duceppe, Alexandre Laverdure, Mikaël Tremblay, Kathy Hince, Amélie Blais, Marie-Pier Cloutier, Richard L. Hébert, Christopher R.J. Kennedy, Alexandra Blais, Liette Gervais, Lilianne Geerts, Lyne Gagnon, Pierre Laurin, Jean-Christophe Simard, Steven R. LaPlante, Sylvie Létourneau, Jean-Francois Thibodeau, François A. Leblond, Brigitte Grouix, Shaun D. Abbott, Boulos Zacharie, Alexandra Felton, Vanessa Marques Quintela, William Gagnon, François Sarra-Bournet
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-16 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-16 (2020)
Non-alcoholic Fatty Liver Disease (NAFLD) is the most common form of liver disease and is associated with metabolic dysregulation. Although G protein-coupled receptor 84 (GPR84) has been associated with inflammation, its role in metabolic regulation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b7b27b3602799ec5543996bcf182aca
http://europepmc.org/articles/PMC7391726
http://europepmc.org/articles/PMC7391726
Autor:
Christopher B. Baigent, Christopher Doyle, Ravi Shekar Yalagala, Shaun D. Abbott, Boulos Zacharie
Publikováno v:
European Journal of Organic Chemistry. 2018:6486-6493
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::792133257897b963755547051703f838
https://doi.org/10.1002/ejoc.201801134
https://doi.org/10.1002/ejoc.201801134
Autor:
Shaun D. Abbott, Lyne Gagnon, Nicole Wilb, Valérie Perron, François Sarra-Bournet, Liette Gervais, Pierre Laurin, Brigitte Grouix, Lilianne Geerts, Christopher Penney, Jean-Simon Duceppe, Boulos Zacharie
Publikováno v:
ChemistryOpen, Vol 7, Iss 9, Pp 737-749 (2018)
Low‐molecular‐weight synthetic molecules 1 with the general 2‐(fluorophenylamino)‐4,6‐disubstituted 1,3,5‐triazine structure and showing anti‐inflammatory and anticancer activities were explored. Structure–activity relationship studie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e01d3dc8d1768156e95629861145aea
https://doi.org/10.1002/open.201800136
https://doi.org/10.1002/open.201800136
Autor:
Jean-Francois Thibodeau, Alexandre Laverdure, Kathy Hince, Richard L. Hébert, Alex Gutsol, William Gagnon, Martin Leduc, Eldjonai Kamto, Liette Gervais, Shaun D. Abbott, Christopher R.J. Kennedy, Francois A. Leblond, Jonathan Richard, Pierre Laurin, Chet E. Holterman, Alexandra Felton, Ming-Zhi Zhang, François Sarra-Bournet, Mikaël Tremblay, Jugurtha Ouboudinar, Lilianne Geerts, Christopher Penney, Lyne Gagnon, Jocelyn Dupuis, Jean-Christophe Simard, Jean-Simon Duceppe, Quang Trinh Nguyen, Marie-Pier Cloutier, Raymond C. Harris, Angelino Calderone, Brigitte Grouix, Boulos Zacharie, Sylvie Létourneau
Publikováno v:
The American Journal of Pathology. 188:1132-1148
Numerous clinical conditions can lead to organ fibrosis and functional failure. There is a great need for therapies that could effectively target pathophysiological pathways involved in fibrosis. GPR40 and GPR84 are G protein–coupled receptors with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7315d43b6a70e40dd65fdef9ae6ea14c
https://doi.org/10.1016/j.ajpath.2018.01.009
https://doi.org/10.1016/j.ajpath.2018.01.009
Autor:
Lyne, Gagnon, Martin, Leduc, Jean-Francois, Thibodeau, Ming-Zhi, Zhang, Brigitte, Grouix, Francois, Sarra-Bournet, William, Gagnon, Kathy, Hince, Mikaël, Tremblay, Lilianne, Geerts, Christopher R J, Kennedy, Richard L, Hébert, Alex, Gutsol, Chet E, Holterman, Eldjonai, Kamto, Liette, Gervais, Jugurtha, Ouboudinar, Jonathan, Richard, Alexandra, Felton, Alexandre, Laverdure, Jean-Christophe, Simard, Sylvie, Létourneau, Marie-Pier, Cloutier, Francois A, Leblond, Shaun D, Abbott, Christopher, Penney, Jean-Simon, Duceppe, Boulos, Zacharie, Jocelyn, Dupuis, Angelino, Calderone, Quang T, Nguyen, Raymond C, Harris, Pierre, Laurin
Publikováno v:
The American journal of pathology. 188(5)
Numerous clinical conditions can lead to organ fibrosis and functional failure. There is a great need for therapies that could effectively target pathophysiological pathways involved in fibrosis. GPR40 and GPR84 are G protein-coupled receptors with f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::198faeef411e2db55cc78141485d6aed
https://pubmed.ncbi.nlm.nih.gov/29454750
https://pubmed.ncbi.nlm.nih.gov/29454750
Autor:
Marie-Pier Cloutier, Martin Leduc, Brigitte Grouix, Shaun D. Abbott, Mikaël Tremblay, Alexandre Laverdure, Kathy Hince, Boulos Zacharie, Lyne Gagnon, Lilianne Geerts, Jean-Simon Duceppe, François Sarra-Bournet, Liette Gervais, Pierre Laurin
Publikováno v:
QJM: An International Journal of Medicine.
PBI-4050 is a first-in-class orally active compound which displays antifibrotic activities in kidney, heart, liver, pancreas and lung models. PBI-4050 was found to be safe and well tolerated in healthy volunteers and in patients with CKD and Type 2 d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3cee2f7e94368020a407bddc12534078
https://doi.org/10.1093/qjmed/hcw120.027
https://doi.org/10.1093/qjmed/hcw120.027
Autor:
Jean-Simon Duceppe, Kathy Hince, Mikaël Tremblay, Shaun D. Abbott, Brigitte Grouix, François Sarra-Bournet, Boulos Zacharie, Alexandra Felton, Lyne Gagnon, Pierre Laurin
Publikováno v:
Journal of Hepatology. 68:S408
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::44ef90e5d89b99111e7e11d6cc1c8ff5
https://doi.org/10.1016/s0168-8278(18)31053-5
https://doi.org/10.1016/s0168-8278(18)31053-5
Autor:
Boulos Zacharie, Valérie Perron, Nancie Moreau, Christopher Penney, Devin Lee, Shaun D. Abbott
Publikováno v:
Synthesis. 2009:283-289
A simple and efficient procedure has been developed for the regioselectiveprotection of aromatic amines in the presence of aliphatic amines.The method is general for the preparation of mono- N-Boc,- N-Cbz, - N-Fmocor - N-Alloc aromatic amines in high
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e196bd04bf79e28c0bb4d5997790a41e
https://doi.org/10.1055/s-0028-1083290
https://doi.org/10.1055/s-0028-1083290