Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Shaul, Lerner"'
Autor:
Lev Shapira, Shaul Lerner, Guila Assayag, Alexandra Vardi, Dikla Haham, Gideon Bar, Vicky Fidelsky Kozokaro, Maayan Elias Robicsek, Immanuel Lerner, Amit Michaeli
Publikováno v:
Frontiers in Drug Discovery, Vol 2 (2022)
Introduction: The COVID-19 pandemic has cast a heavy toll in human lives and global economics. COVID-19 is caused by the SARS-CoV-2 virus, which infects cells via its spike protein binding human ACE2.Methods: To discover potential inhibitory peptidom
Externí odkaz:
https://doaj.org/article/7a6cb3b1fa4a404799dd97bf143d0409
Autor:
Shaul Lerner, Elmira Anderzhanova, Sima Verbitsky, Raya Eilam, Yael Kuperman, Michael Tsoory, Yuri Kuznetsov, Alexander Brandis, Tevie Mehlman, Ram Mazkereth, Robert McCarter, Menahem Segal, Sandesh C.S. Nagamani, Alon Chen, Ayelet Erez, Fabienne Dietrich Alber, Talin Babikian, Heidi Bender, Christopher Boys, David Breiger, Corinna Buerger, Peter Burgard, Mina Nguyen-Driver, Benjamin Goodlett, Elizabeth Kerr, Casey Krueger, Eva Mamak, Jacqueline H. Sanz, David Schwartz, Susan Caudle, Arianna Stefanos, Rachel Tangen, Magdalena Walter, Susan Waisbren, Greta Wilkening
Publikováno v:
Cell Reports, Vol 29, Iss 8, Pp 2144-2153.e7 (2019)
Summary: Patients with germline mutations in the urea-cycle enzyme argininosuccinate lyase (ASL) are at risk for developing neurobehavioral and cognitive deficits. We find that ASL is prominently expressed in the nucleus locus coeruleus (LC), the cen
Externí odkaz:
https://doaj.org/article/976ff388391d44aba3c02d09b832485b
Autor:
Ayelet Erez, Carmen Diez-Fernandez, Carlo Dionisi-Vici, Shaul Lerner, Giusy Ranucci, Julien Baruteau, Sandesh C.S. Nagamani, Johannes Häberle, Paul Gissen
Publikováno v:
Journal of Inherited Metabolic Disease. 42:1147-1161
The first patients affected by argininosuccinic aciduria (ASA) were reported 60 years ago. The clinical presentation was initially described as similar to other urea cycle defects, but increasing evidence has shown overtime an atypical systemic pheno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77c90b3550c08b39777d7cd94d4c7e11
https://doi.org/10.1002/jimd.12047
https://doi.org/10.1002/jimd.12047
Autor:
Shaul, Lerner, Raya, Eilam, Lital, Adler, Julien, Baruteau, Topaz, Kreiser, Michael, Tsoory, Alexander, Brandis, Tevie, Mehlman, Mina, Ryten, Juan A, Botia, Sonia Garcia, Ruiz, Alejandro Cisterna, Garcia, Carlo, Dionisi-Vici, Giusy, Ranucci, Marco, Spada, Ram, Mazkereth, Robert, McCarter, Rima, Izem, Thomas J, Balmat, Rachel, Richesson, Ehud, Gazit, Sandesh C S, Nagamani, Marc, Yudkoff
Publikováno v:
Human Genetics
Argininosuccinate lyase (ASL) is essential for the NO-dependent regulation of tyrosine hydroxylase (TH) and thus for catecholamine production. Using a conditional mouse model with loss of ASL in catecholamine neurons, we demonstrate that ASL is expre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b55b04fcb401eba776e6c8db6bbac0e0
https://pubmed.ncbi.nlm.nih.gov/34417872
https://pubmed.ncbi.nlm.nih.gov/34417872
Autor:
Hadas Landesman, Ayelet Erez, Omer Goldman, Sergey Malitsky, Sivan Galai, Alexander Brandis, Tevi Mehlman, Keyur Talsania, S. Eleonore Koehler, Yael Kuperman, Eytan Ruppin, Lisha Qiu Jin Lim, Igor Ulitsky, Angel Porgador, Yongmei Zhao, Roni Oren, Shaul Lerner, Joo Sang Lee, Maxim Itkin, Hila Weiss Tishler, Rotem Katzir, Shiran Rabinovich, Nir Peled, Noa Stettner, Lital Adler, Yuri Kuznetsov, Rom Keshet, Muhammed Iraqi, Tsai-wei Shen, Yarden Ariav
Publikováno v:
Nature Cancer
Nature Cancer, 1(9), 894-908. Nature Publishing Group
Nature Cancer, 1(9), 894-908. Nature Publishing Group
Argininosuccinate synthase (ASS1) downregulation in different tumors has been shown to support cell proliferation and yet, in several common cancer subsets ASS1 expression associates with poor patient prognosis. Here we demonstrate that ASS1 expressi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::193f750c2610f8dd4d6709f2a1e2b1be
Autor:
Rina Aharoni, Raya Eilam, Shaul Lerner, Efrat Shavit-Stein, Amir Dori, Joab Chapman, Ruth Arnon
Publikováno v:
International Journal of Molecular Sciences; Volume 22; Issue 24; Pages: 13419
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 13419, p 13419 (2021)
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 13419, p 13419 (2021)
Axonal and neuronal pathologies are a central constituent of multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE), induced by the myelin oligodendrocyte glycoprotein (MOG) 35–55 peptide. In this study, we in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7eef498bf3677fb760910010c7be7311
https://doi.org/10.3390/ijms222413419
https://doi.org/10.3390/ijms222413419