Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Shatha Abuhammad"'
Autor:
Lok Hang Chan, Peihan Wang, Shatha Abuhammad, Lydia Rui Jia Lim, Joseph Cursons, Karen E. Sheppard, David L. Goode
Publikováno v:
PLoS ONE, Vol 18, Iss 11 (2023)
Externí odkaz:
https://doaj.org/article/45fdcea7d05941a88c6ee4ed0e1f1cf8
Publikováno v:
Case Reports in Dermatology, Vol 9, Iss 1, Pp 65-68 (2017)
A 47-year-old female patient with rheumatoid arthritis (RA) treated with methotrexate, was diagnosed with metastatic melanoma. After surgical removal of the tumor, the patient started treatment with ipilimumab while methotrexate was stopped. One week
Externí odkaz:
https://doaj.org/article/c7ec067e73b04ea7b672845a33ea43fe
Autor:
Karen E. Sheppard, Shatha AbuHammad
Publikováno v:
Molecular & Cellular Oncology, Vol 6, Iss 6 (2019)
Cyclin-dependent kinase −4 and −6 (CDK4/6) inhibitors are currently being assessed in clinical trials for the treatment of many cancers including melanoma. While investigating the mechanisms of CDK4/6 inhibitor resistance in melanoma, we uncovere
Externí odkaz:
https://doaj.org/article/8cfcc15c6a47416aa66081cd570b960d
Autor:
Ygal Haupt, Prerana Ghosh, Carleen Cullinane, Natalie Brajanovski, Gretchen Poortinga, Ian P. Street, Emily J. Lelliott, Laura Kirby, Keefe T. Chan, Mark G. Devlin, Richard B. Pearson, Elaine Sanij, Shatha AbuHammad, Lorey K. Smith, Michael A. Davies, Anthony T. Papenfuss, Alison Slater, Kerry Ardley, Sue Haupt, Karen E. Sheppard, Peter Lau, David J. Curtis, Hendrik Falk, Stupple Paul Anthony, Huiqin Chen, Grant A. McArthur, Margarete Kleinschmidt, Zoe Bacolas, Teresa Ward, Claire Martin, Aparna D. Rao, Ismael A. Vergara
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Targeting CDK4/6 shows great promise in the treatment of many solid cancers, including melanoma. This study has uncovered a mechanism of action of CDK4/6 inhibitors in regulating the MDM4 oncogene and the tumor suppressor, p53. In melano
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3c463a6eb580dc81263393215e3d7a1
https://doi.org/10.1073/pnas.1901323116
https://doi.org/10.1073/pnas.1901323116
Autor:
Sabina Signoretti, Laure Hirsch, Adam S. Feldman, Thomas Denize, Xin Gao, Jiao Li, Jihye Park, Gwo-Shu Mary Lee, Emma R. Garner, Chris Labaki, Daniel Y.C. Heng, Ananthan Sadagopan, Ziad Bakouny, Catherine J. Wu, David F. McDermott, Bradley Alexander McGregor, Vidyalakshmi Sethunath, Eliezer M. Van Allen, Filipe Lf Carvalho, Natalie I. Vokes, Steven L. Chang, Shaan Dudani, Shatha AbuHammad, Toni K. Choueiri, Stephen Tang, Chun-Loo Gan, Praful Ravi, Nebiyou Y. Metaferia, Michelle S. Hirsch, Emily Walton, David A. Braun, Rizwan Haq, Destiny West, Srinivas R. Viswanathan, Gabrielle Bouchard, Alma Imamovic, Cora A. Ricker, John A. Steinharter, Jackson Nyman
Translocation renal cell carcinoma (tRCC) is an aggressive and poorly-characterized subtype of kidney cancer driven by MiT/TFE gene fusions. Here, we define the landmarks of tRCC through an integrative analysis of 152 tRCC patients identified across
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6950b889cd81d344eda797d5061d34d3
https://doi.org/10.1101/2021.04.14.439908
https://doi.org/10.1101/2021.04.14.439908
Autor:
Nancy T, Santiappillai, Shatha, Abuhammad, Alison, Slater, Laura, Kirby, Grant A, McArthur, Karen E, Sheppard, Lorey K, Smith
Publikováno v:
Cancers
Simple Summary Cyclin-dependent kinases 4 and 6 (CDK4/6) are key enzymes controlling the cell cycle. CDK4/6 inhibitors are being tested in multiple clinical trials for a range of cancers including melanoma, and a deeper understanding of how they inte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cc707b3fc9f90d69047fd86463507817
https://pubmed.ncbi.nlm.nih.gov/33572972
https://pubmed.ncbi.nlm.nih.gov/33572972
Autor:
Stephen Tang, Vidyalakshmi Sethunath, Nebiyou Y. Metaferia, Marina F. Nogueira, Daniel S. Gallant, Emma R. Garner, Lauren A. Lairson, Christopher M. Penney, Jiao Li, Maya K. Gelbard, Sarah Abou Alaiwi, Ji-Heui Seo, Justin H. Hwang, Craig A. Strathdee, Sylvan C. Baca, Shatha AbuHammad, Xiaoyang Zhang, John G. Doench, William C. Hahn, David Y. Takeda, Matthew L. Freedman, Peter S. Choi, Srinivas R. Viswanathan
Publikováno v:
Cell Rep
Androgen receptor (AR) signaling is the central driver of prostate cancer across disease states. While androgen deprivation therapy (ADT) is effective in the initial treatment of prostate cancer, resistance to ADT or to next-generation androgen pathw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74705f949afe5f34a963ebc736db4285
https://pubmed.ncbi.nlm.nih.gov/35993121
https://pubmed.ncbi.nlm.nih.gov/35993121
Autor:
Srinivas R. Viswanathan, Jiao Li, David Y. Takeda, John G. Doench, William C. Hahn, Xiaoyang Zhang, Sylvan C. Baca, Marina F. Nogueira, Craig A. Strathdee, Matthew L. Freedman, Stephen Tang, Sarah Abou Alaiwi, Maya K. Gelbard, Shatha AbuHammad, Nebiyou Y. Metaferia, Peter S. Choi, Ji-Heui Seo, Justin H. Hwang
Androgen receptor (AR) signaling is the central driver of prostate cancer across disease states. While androgen deprivation therapy (ADT) is effective in the initial treatment of prostate cancer, resistance to ADT or to next-generation androgen pathw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7ce2ebce03c292d060a50721a46713d0
https://doi.org/10.1101/2020.06.17.156034
https://doi.org/10.1101/2020.06.17.156034
Autor:
Ziad Bakouny, Ananthan Sadagopan, Praful Ravi, Nebiyou Y. Metaferia, Jiao Li, Shatha AbuHammad, Stephen Tang, Thomas Denize, Emma R. Garner, Xin Gao, David A. Braun, Laure Hirsch, John A. Steinharter, Gabrielle Bouchard, Emily Walton, Destiny West, Chris Labaki, Shaan Dudani, Chun-Loo Gan, Vidyalakshmi Sethunath, Filipe L.F. Carvalho, Alma Imamovic, Cora Ricker, Natalie I. Vokes, Jackson Nyman, Jacob E. Berchuck, Jihye Park, Michelle S. Hirsch, Rizwan Haq, Gwo-Shu Mary Lee, Bradley A. McGregor, Steven L. Chang, Adam S. Feldman, Catherine J. Wu, David F. McDermott, Daniel Y.C. Heng, Sabina Signoretti, Eliezer M. Van Allen, Toni K. Choueiri, Srinivas R. Viswanathan
Publikováno v:
Cell Rep
Translocation renal cell carcinoma (tRCC) is a poorly-characterized subtype of kidney cancer driven by MiT/TFE gene fusions. Here, we define the landmarks of tRCC through an integrative analysis of 152 patients with tRCC identified across genomic, cl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c09f4b8dee08d6eac246ec1f8a214c8f
https://doi.org/10.1016/j.celrep.2021.110190
https://doi.org/10.1016/j.celrep.2021.110190
Autor:
Laura Kirby, Shatha AbuHammad, Richard J. Young, Peter Lau, Grant A. McArthur, Claire Martin, Katrina Meeth, Karen E. Sheppard, Jessica Michie, Kelly M Ramsbottom, Nicole M. Haynes, Rachael Walker, Fernando Souza-Fonseca-Guimaraes, Jane Oliaro, Emily J. Lelliott, Carleen Cullinane, Alison Slater
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
Both targeted therapy and immunotherapy have been used successfully to treat melanoma, but the development of resistance and poor response rates to the individual therapies has limited their success. Designing rational combinations of targeted therap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a38dd51f671e03394cc9d4e1d445ef1
https://doi.org/10.1038/s41598-018-37883-y
https://doi.org/10.1038/s41598-018-37883-y