Zobrazeno 1 - 10
of 76
pro vyhledávání: '"Shasi, V. Kalivendi"'
Publikováno v:
ACS Chemical Neuroscience. 12:4175-4186
The sequential cleavage of full-length amyloid precursor protein (APP) by secretases has been at the center of efforts for understanding the onset of Alzheimer's disease (AD). A decrease in α-secretase activity was observed during the progression of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee18979ee4afa4b04ca011c816b76745
https://doi.org/10.1021/acschemneuro.1c00582
https://doi.org/10.1021/acschemneuro.1c00582
Publikováno v:
Mitochondrion. 46:158-163
Amongst various therapeutic properties of the natural product embelin, its anti-cancer effects are being extensively studied. We observed that, embelin induced apoptosis in A549 cells lacking functional mitochondria (ρ0 cells) indicating that its mi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d71ab10dcee68212e5c566b6f7ff887f
https://doi.org/10.1016/j.mito.2018.04.007
https://doi.org/10.1016/j.mito.2018.04.007
Autor:
Krishna Madhuri Manda, Deepthi Yedlapudi, Srikanth Korukonda, Sreedhar Bojja, Shasi V Kalivendi
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e98657 (2014)
Abnormal oligomerization and aggregation of α-synuclein (α-syn/WT-syn) has been shown to be a precipitating factor in the pathophysiology of Parkinson's disease (PD). Earlier observations on the induced-alternative splicing of α-syn by Parkinsonis
Externí odkaz:
https://doaj.org/article/d170488afb91422e82320cfc57e84b62
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e87050 (2014)
The natural product embelin has been demonstrated to possess a wide range of therapeutic properties, however, the mechanisms by which it exerts anticancer effects are not yet clear. By monitoring the molecular changes associated during early apoptoti
Externí odkaz:
https://doaj.org/article/461ae71ea5174394b6911a8c8eb77a9c
Autor:
Parag S. Khursade, Ashok Kumar Tiwari, Bhimapaka China Raju, Shasi V. Kalivendi, Reddy Shetty Prakasham, Kommera Rajkumar, Amtul Zehra, Thampunuri Ramalinga Murthy
Publikováno v:
ChemistrySelect. 3:13729-13735
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d0c18300d8d49e72a09e75d5b55f29c
https://doi.org/10.1002/slct.201802809
https://doi.org/10.1002/slct.201802809
Autor:
René Grée, Sophie Barillé-Nion, Fabien Gautier, Paul Mosset, Olivier Tasseau, Philippe Juin, Niharika Amireddy, Shasi V. Kalivendi, Nicolas Levoin
Publikováno v:
Medicinal Chemistry Research
Medicinal Chemistry Research, Springer Verlag, 2018, 27 (4), pp.1050-1065. ⟨10.1007/s00044-017-2127-z⟩
Medicinal Chemistry Research, 2018, 27 (4), pp.1050-1065. ⟨10.1007/s00044-017-2127-z⟩
Medicinal Chemistry Research, Springer Verlag, 2018, 27 (4), pp.1050-1065. ⟨10.1007/s00044-017-2127-z⟩
Medicinal Chemistry Research, 2018, 27 (4), pp.1050-1065. ⟨10.1007/s00044-017-2127-z⟩
A series of new benzyl-substituted hydroquinones has been prepared by short and flexible routes. Such molecules are simplified analogs of bioactive natural terpenes. Preliminary studies have established, for some of these derivatives, promising cytot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2871819bafd8342dc4dd0329d70b0501
https://doi.org/10.1007/s00044-017-2127-z
https://doi.org/10.1007/s00044-017-2127-z
Autor:
Niharika Amireddy, Srinivas N. Puttapaka, Ravali L. Vinnakota, Halley G. Ravuri, Swaroop Thonda, Shasi V. Kalivendi
Publikováno v:
The Journal of Biological Chemistry
Mitochondria play a primary role in the pathophysiology of Parkinson's disease (PD), and small molecules that counteract the initial stages of disease may offer therapeutic benefit. In this regard, we have examined whether the off-target effects of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::911654c6e7ff132f549bec55ed8ee246
https://doi.org/10.1016/j.jbc.2021.100864
https://doi.org/10.1016/j.jbc.2021.100864
Autor:
Thampunuri Ramalinga Murthy, Cherupally Dayakar, Pathi Suman, Shasi V. Kalivendi, Kommera Rajkumar, Bhimapaka China Raju
Publikováno v:
Medicinal Chemistry Research. 27:80-94
A series of pyridinylchalcones 3a–q, chromanones 4a–q were prepared and screened for their in vitro anti-proliferative activity against four human cancer cell lines viz., cervical (HeLa), lung adenocarcinoma (A549), prostate (DU-145) and breast (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8e83ee82e173d7a3a5b5c9e23258880f
https://doi.org/10.1007/s00044-017-2034-3
https://doi.org/10.1007/s00044-017-2034-3
Autor:
Swaroop Thonda, Srinivas N. Puttapaka, Ravali L. Vinnakota, Shasi V. Kalivendi, Niharika Amireddy, Halley G. Ravuri
Publikováno v:
Journal of Biological Chemistry. 292:15731-15743
Mitochondria play a primary role in the pathophysiology of Parkinson's disease (PD), and small molecules that counteract the initial stages of disease may offer therapeutic benefit. In this regard, we have examined whether the off-target effects of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dad112574634f26b925ac6363c1eb3c
https://doi.org/10.1074/jbc.m117.791863
https://doi.org/10.1074/jbc.m117.791863
Publikováno v:
Biochimica et biophysica acta. Bioenergetics. 1861(3)
Parkinson's disease (PD) is a chronic neurodegenerative disease characterized by the death of dopamine neurons of Substantia nigra pars compacta (SNpc) leading to motor deficits. Amongst the mechanisms proposed, mitochondrial dysfunction, reduced com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::483aeca127ca50c4e2746fb6c49ccfee
https://pubmed.ncbi.nlm.nih.gov/31987812
https://pubmed.ncbi.nlm.nih.gov/31987812