Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Shashirekha S, Markandaiah"'
Autor:
Mark W Urban, Brittany A Charsar, Nicolette M Heinsinger, Shashirekha S Markandaiah, Lindsay Sprimont, Wei Zhou, Eric V Brown, Nathan T Henderson, Samantha J Thomas, Biswarup Ghosh, Rachel E Cain, Davide Trotti, Piera Pasinelli, Megan C Wright, Matthew B Dalva, Angelo C Lepore
Publikováno v:
eLife, Vol 12 (2024)
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by motor neuron loss. Importantly, non-neuronal cell types such as astrocytes also play significant roles in disease pathogenesis. However, mechanisms of astrocyte contr
Externí odkaz:
https://doaj.org/article/018e0a8bf2cb4c7db4d6c298aaf9f962
Autor:
Brandie Morris Verdone, Maria Elena Cicardi, Xinmei Wen, Sindhu Sriramoji, Katelyn Russell, Shashirekha S. Markandaiah, Brigid K. Jensen, Karthik Krishnamurthy, Aaron R. Haeusler, Piera Pasinelli, Davide Trotti
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-17 (2022)
Abstract Translation of the hexanucleotide G4C2 expansion associated with C9orf72 amyotrophic lateral sclerosis and frontotemporal dementia (ALS/FTD) produces five different dipeptide repeat protein (DPR) species that can confer toxicity. There is ye
Externí odkaz:
https://doaj.org/article/19ca21d95d3242fdb4694723b5e2de9e
Autor:
Silvia Bonanno, Loqman A. Mohamed, Piera Pasinelli, Davide Trotti, Shashirekha S. Markandaiah
Publikováno v:
The AAPS Journal. 19:1600-1614
The blood–brain barrier (BBB) is essential for proper neuronal function, homeostasis, and protection of the central nervous system (CNS) microenvironment from blood-borne pathogens and neurotoxins. The BBB is also an impediment for CNS penetration
Autor:
Piera Pasinelli, Silvia Bonanno, Davide Trotti, Loqman A. Mohamed, Shashirekha S. Markandaiah
Publikováno v:
Exp Neurol
In amyotrophic lateral sclerosis (ALS), upregulation in expression and activity of the ABC transporter P-glycoprotein (P-gp) driven by disease advancement progressively reduces CNS penetration and efficacy of the ALS drug, riluzole. Post-mortem spina
Autor:
Jean Philippe Richard, Kevin McAvoy, Shashirekha S. Markandaiah, Mark Sarlo, Piera Pasinelli, Hisham Qosa, Nicholas J. Maragakis, Davide Trotti, Michael R. Jablonski, Jessica Lichter
Publikováno v:
Glia. 64:1298-1313
The efficacy of drugs targeting the CNS is influenced by their limited brain access, which can lead to complete pharmacoresistance. Recently a tissue-specific and selective upregulation of the multidrug efflux transporter ABCB1 or P-glycoprotein (P-g
Autor:
Angelo C. Lepore, Davide Trotti, Victoria J. Gennaro, Michael R. Jablonski, Piera Pasinelli, Ke Li, Ni J. Meng, Shashirekha S. Markandaiah, Dena Jacob
Publikováno v:
Annals of Clinical and Translational Neurology
The limited progress in identifying successful therapies in Amyotrophic Lateral Sclerosis (ALS) has only resulted in one moderately effective pharmacological agent, riluzole.1,2 In research on the SOD1-G93A mouse model of ALS, riluzole showed a modes
Autor:
Hisham, Qosa, Jessica, Lichter, Mark, Sarlo, Shashirekha S, Markandaiah, Kevin, McAvoy, Jean-Philippe, Richard, Michael R, Jablonski, Nicholas J, Maragakis, Piera, Pasinelli, Davide, Trotti
Publikováno v:
Glia. 64(8)
The efficacy of drugs targeting the CNS is influenced by their limited brain access, which can lead to complete pharmacoresistance. Recently a tissue-specific and selective upregulation of the multidrug efflux transporter ABCB1 or P-glycoprotein (P-g
Autor:
John Monaghan, Udai Bhan Pandey, Justin K. Ichida, Shashirekha S. Markandaiah, Thomas Westergard, Wenzhi Tan, Davide Trotti, Piera Pasinelli, Neil A. Shneider, Shaoyu Lin, Xinmei Wen, Karthik Krishnamurthy, Yingxiao Shi
Publikováno v:
Neuron. (6):1213-1225
SummaryExpanded GGGGCC (G4C2) nucleotide repeats within the C9ORF72 gene are the most common genetic mutation associated with both amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Sense and antisense transcripts of these expansi
Autor:
Mohamed LA; Jefferson Weinberg ALS Center, Vickie and Jack Farber Institute for Neuroscience, Department of Neuroscience, Thomas Jefferson University Hospitals, 900 Walnut Street, Philadelphia, Pennsylvania, 19107, USA. Loqman.Mohamed.Science@gmail.com., Markandaiah S; Jefferson Weinberg ALS Center, Vickie and Jack Farber Institute for Neuroscience, Department of Neuroscience, Thomas Jefferson University Hospitals, 900 Walnut Street, Philadelphia, Pennsylvania, 19107, USA., Bonanno S; Jefferson Weinberg ALS Center, Vickie and Jack Farber Institute for Neuroscience, Department of Neuroscience, Thomas Jefferson University Hospitals, 900 Walnut Street, Philadelphia, Pennsylvania, 19107, USA., Pasinelli P; Jefferson Weinberg ALS Center, Vickie and Jack Farber Institute for Neuroscience, Department of Neuroscience, Thomas Jefferson University Hospitals, 900 Walnut Street, Philadelphia, Pennsylvania, 19107, USA., Trotti D; Jefferson Weinberg ALS Center, Vickie and Jack Farber Institute for Neuroscience, Department of Neuroscience, Thomas Jefferson University Hospitals, 900 Walnut Street, Philadelphia, Pennsylvania, 19107, USA.
Publikováno v:
The AAPS journal [AAPS J] 2017 Nov; Vol. 19 (6), pp. 1600-1614. Date of Electronic Publication: 2017 Aug 04.