Oxidative stress initiates hemodynamic change in CKD-induced heart disease.

Autor: Sen P; Institute for Surgical Research, Walter Brendel Center of Experimental Medicine, University Clinic Munich, LMU Munich, Marchioninistrasse 68, 81377, Munich, Germany.; German Center for Cardiovascular Research (DZHK), Munich Heart Alliance (MHA), Partner Site Munich, Munich, Germany.; Interfaculty Center for Endocrine and Cardiovascular Disease Network Modelling and Clinical Transfer (ICONLMU), LMU Munich, Munich, Germany., Hamers J; Institute for Surgical Research, Walter Brendel Center of Experimental Medicine, University Clinic Munich, LMU Munich, Marchioninistrasse 68, 81377, Munich, Germany.; German Center for Cardiovascular Research (DZHK), Munich Heart Alliance (MHA), Partner Site Munich, Munich, Germany.; Interfaculty Center for Endocrine and Cardiovascular Disease Network Modelling and Clinical Transfer (ICONLMU), LMU Munich, Munich, Germany., Sittig T; Institute for Surgical Research, Walter Brendel Center of Experimental Medicine, University Clinic Munich, LMU Munich, Marchioninistrasse 68, 81377, Munich, Germany.; German Center for Cardiovascular Research (DZHK), Munich Heart Alliance (MHA), Partner Site Munich, Munich, Germany.; Interfaculty Center for Endocrine and Cardiovascular Disease Network Modelling and Clinical Transfer (ICONLMU), LMU Munich, Munich, Germany., Shashikadze B; Gene Center, LMU Munich, Munich, Germany., d'Ambrosio L; Institute for Surgical Research, Walter Brendel Center of Experimental Medicine, University Clinic Munich, LMU Munich, Marchioninistrasse 68, 81377, Munich, Germany.; German Center for Cardiovascular Research (DZHK), Munich Heart Alliance (MHA), Partner Site Munich, Munich, Germany.; Interfaculty Center for Endocrine and Cardiovascular Disease Network Modelling and Clinical Transfer (ICONLMU), LMU Munich, Munich, Germany., Stöckl JB; Gene Center, LMU Munich, Munich, Germany., Bierschenk S; Institute for Surgical Research, Walter Brendel Center of Experimental Medicine, University Clinic Munich, LMU Munich, Marchioninistrasse 68, 81377, Munich, Germany.; Interfaculty Center for Endocrine and Cardiovascular Disease Network Modelling and Clinical Transfer (ICONLMU), LMU Munich, Munich, Germany., Zhang H; Institute for Surgical Research, Walter Brendel Center of Experimental Medicine, University Clinic Munich, LMU Munich, Marchioninistrasse 68, 81377, Munich, Germany.; German Center for Cardiovascular Research (DZHK), Munich Heart Alliance (MHA), Partner Site Munich, Munich, Germany., d'Alessio C; Institute for Surgical Research, Walter Brendel Center of Experimental Medicine, University Clinic Munich, LMU Munich, Marchioninistrasse 68, 81377, Munich, Germany.; German Center for Cardiovascular Research (DZHK), Munich Heart Alliance (MHA), Partner Site Munich, Munich, Germany., Zandbergen LM; Institute for Surgical Research, Walter Brendel Center of Experimental Medicine, University Clinic Munich, LMU Munich, Marchioninistrasse 68, 81377, Munich, Germany.; German Center for Cardiovascular Research (DZHK), Munich Heart Alliance (MHA), Partner Site Munich, Munich, Germany.; Interfaculty Center for Endocrine and Cardiovascular Disease Network Modelling and Clinical Transfer (ICONLMU), LMU Munich, Munich, Germany.; Department of Cardiology, Erasmus MC, Rotterdam, The Netherlands., Pauly V; Institute for Surgical Research, Walter Brendel Center of Experimental Medicine, University Clinic Munich, LMU Munich, Marchioninistrasse 68, 81377, Munich, Germany.; German Center for Cardiovascular Research (DZHK), Munich Heart Alliance (MHA), Partner Site Munich, Munich, Germany.; Department of Medicine I, University Hospital, LMU Munich, Marchioninistrasse 15, 81377, Munich, Germany.; Interfaculty Center for Endocrine and Cardiovascular Disease Network Modelling and Clinical Transfer (ICONLMU), LMU Munich, Munich, Germany., Clauss S; Institute for Surgical Research, Walter Brendel Center of Experimental Medicine, University Clinic Munich, LMU Munich, Marchioninistrasse 68, 81377, Munich, Germany.; German Center for Cardiovascular Research (DZHK), Munich Heart Alliance (MHA), Partner Site Munich, Munich, Germany.; Department of Medicine I, University Hospital, LMU Munich, Marchioninistrasse 15, 81377, Munich, Germany.; Interfaculty Center for Endocrine and Cardiovascular Disease Network Modelling and Clinical Transfer (ICONLMU), LMU Munich, Munich, Germany., Wolf E; Gene Center, LMU Munich, Munich, Germany., Dendorfer A; Institute for Surgical Research, Walter Brendel Center of Experimental Medicine, University Clinic Munich, LMU Munich, Marchioninistrasse 68, 81377, Munich, Germany., Fröhlich T; Gene Center, LMU Munich, Munich, Germany., Merkus D; Institute for Surgical Research, Walter Brendel Center of Experimental Medicine, University Clinic Munich, LMU Munich, Marchioninistrasse 68, 81377, Munich, Germany. daphne.merkus@med.uni-muenchen.de.; German Center for Cardiovascular Research (DZHK), Munich Heart Alliance (MHA), Partner Site Munich, Munich, Germany. daphne.merkus@med.uni-muenchen.de.; Interfaculty Center for Endocrine and Cardiovascular Disease Network Modelling and Clinical Transfer (ICONLMU), LMU Munich, Munich, Germany. daphne.merkus@med.uni-muenchen.de.; Department of Cardiology, Erasmus MC, Rotterdam, The Netherlands. daphne.merkus@med.uni-muenchen.de.

Publikováno v: Basic research in cardiology [Basic Res Cardiol] 2024 Dec; Vol. 119 (6), pp. 957-971. Date of Electronic Publication: 2024 Oct 15.

Structural and proteomic repercussions of growth hormone receptor deficiency on the pituitary gland: Lessons from a translational pig model.

Autor: Shashikadze B; Laboratory for Functional Genome Analysis (LAFUGA), Gene Center, Ludwig-Maximilians-Universität München, Munich, Germany., Franzmeier S; Institute of Veterinary Pathology at the Center for Clinical Veterinary Medicine, Ludwig-Maximilians-Universität München, Munich, Germany., Hofmann I; Institute of Veterinary Pathology at the Center for Clinical Veterinary Medicine, Ludwig-Maximilians-Universität München, Munich, Germany., Kraetzl M; Chair for Molecular Animal Breeding and Biotechnology, Gene Center and Department of Veterinary Sciences, Ludwig-Maximilians-Universität München, Munich, Germany.; Center for Innovative Medical Models (CiMM), Ludwig-Maximilians-Universität München, Oberschleissheim, Germany., Flenkenthaler F; Laboratory for Functional Genome Analysis (LAFUGA), Gene Center, Ludwig-Maximilians-Universität München, Munich, Germany., Blutke A; Institute of Veterinary Pathology at the Center for Clinical Veterinary Medicine, Ludwig-Maximilians-Universität München, Munich, Germany., Fröhlich T; Laboratory for Functional Genome Analysis (LAFUGA), Gene Center, Ludwig-Maximilians-Universität München, Munich, Germany., Wolf E; Laboratory for Functional Genome Analysis (LAFUGA), Gene Center, Ludwig-Maximilians-Universität München, Munich, Germany.; Chair for Molecular Animal Breeding and Biotechnology, Gene Center and Department of Veterinary Sciences, Ludwig-Maximilians-Universität München, Munich, Germany.; Center for Innovative Medical Models (CiMM), Ludwig-Maximilians-Universität München, Oberschleissheim, Germany., Hinrichs A; Chair for Molecular Animal Breeding and Biotechnology, Gene Center and Department of Veterinary Sciences, Ludwig-Maximilians-Universität München, Munich, Germany.; Center for Innovative Medical Models (CiMM), Ludwig-Maximilians-Universität München, Oberschleissheim, Germany.

Publikováno v: Journal of neuroendocrinology [J Neuroendocrinol] 2024 Jul; Vol. 36 (7), pp. e13277. Date of Electronic Publication: 2023 May 09.

Maternal hyperglycemia induces alterations in hepatic amino acid, glucose and lipid metabolism of neonatal offspring: Multi-omics insights from a diabetic pig model.

Autor: Shashikadze B; Laboratory for Functional Genome Analysis (LAFUGA), Gene Center, LMU Munich, 81377 Munich, Germany., Valla L; Molecular Animal Breeding and Biotechnology, Gene Center and Department of Veterinary Sciences, LMU Munich, 81377 Munich, Germany; MWM Biomodels GmbH, 84184 Tiefenbach, Germany., Lombardo SD; Max Perutz Labs, Vienna Biocenter Campus (VBC), 1030 Vienna, Austria; University of Vienna, Center for Molecular Biology, Department of Structural and Computational Biology, 1030 Vienna, Austria; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria., Prehn C; Metabolomics and Proteomics Core (MPC), Helmholtz Zentrum München, 85764 Neuherberg, Germany., Haid M; Metabolomics and Proteomics Core (MPC), Helmholtz Zentrum München, 85764 Neuherberg, Germany., Riols F; Metabolomics and Proteomics Core (MPC), Helmholtz Zentrum München, 85764 Neuherberg, Germany., Stöckl JB; Laboratory for Functional Genome Analysis (LAFUGA), Gene Center, LMU Munich, 81377 Munich, Germany., Elkhateib R; Laboratory for Functional Genome Analysis (LAFUGA), Gene Center, LMU Munich, 81377 Munich, Germany., Renner S; Molecular Animal Breeding and Biotechnology, Gene Center and Department of Veterinary Sciences, LMU Munich, 81377 Munich, Germany; German Center for Diabetes Research (DZD), 85764 Neuherberg, Germany; Center for Innovative Medical Models (CiMM), LMU Munich, 85764 Oberschleißheim, Germany., Rathkolb B; Molecular Animal Breeding and Biotechnology, Gene Center and Department of Veterinary Sciences, LMU Munich, 81377 Munich, Germany; German Center for Diabetes Research (DZD), 85764 Neuherberg, Germany; Institute of Experimental Genetics, German Mouse Clinic, Helmholtz Munich, 85764 Neuherberg, Germany., Menche J; Max Perutz Labs, Vienna Biocenter Campus (VBC), 1030 Vienna, Austria; University of Vienna, Center for Molecular Biology, Department of Structural and Computational Biology, 1030 Vienna, Austria; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria; University of Vienna, Faculty of Mathematics, 1090 Vienna, Austria., Hrabĕ de Angelis M; German Center for Diabetes Research (DZD), 85764 Neuherberg, Germany; Institute of Experimental Genetics, German Mouse Clinic, Helmholtz Munich, 85764 Neuherberg, Germany; Experimental Genetics, School of Life Science Weihenstephan, Technische Universität München, 85354 Freising, Germany., Wolf E; Laboratory for Functional Genome Analysis (LAFUGA), Gene Center, LMU Munich, 81377 Munich, Germany; Molecular Animal Breeding and Biotechnology, Gene Center and Department of Veterinary Sciences, LMU Munich, 81377 Munich, Germany; German Center for Diabetes Research (DZD), 85764 Neuherberg, Germany; Center for Innovative Medical Models (CiMM), LMU Munich, 85764 Oberschleißheim, Germany., Kemter E; Molecular Animal Breeding and Biotechnology, Gene Center and Department of Veterinary Sciences, LMU Munich, 81377 Munich, Germany; German Center for Diabetes Research (DZD), 85764 Neuherberg, Germany; Center for Innovative Medical Models (CiMM), LMU Munich, 85764 Oberschleißheim, Germany. Electronic address: kemter@genzentrum.lmu.de., Fröhlich T; Laboratory for Functional Genome Analysis (LAFUGA), Gene Center, LMU Munich, 81377 Munich, Germany. Electronic address: frohlich@genzentrum.lmu.de.

Publikováno v: Molecular metabolism [Mol Metab] 2023 Sep; Vol. 75, pp. 101768. Date of Electronic Publication: 2023 Jul 04.

Systemic deletion of DMD exon 51 rescues clinically severe Duchenne muscular dystrophy in a pig model lacking DMD exon 52.

Autor: Stirm M; Chair for Molecular Animal Breeding and Biotechnology, Gene Center and Department of Veterinary Sciences, LMU Munich, Munich 81377, Germany.; Center for Innovative Medical Models, Department of Veterinary Sciences, LMU Munich, Oberschleissheim 85764, Germany., Shashikadze B; Laboratory for Functional Genome Analysis, Gene Center, LMU Munich, Munich 81377, Germany., Blutke A; Institute of Veterinary Pathology, Center for Clinical Veterinary Medicine, LMU Munich, Munich 80539, Germany., Kemter E; Chair for Molecular Animal Breeding and Biotechnology, Gene Center and Department of Veterinary Sciences, LMU Munich, Munich 81377, Germany.; Center for Innovative Medical Models, Department of Veterinary Sciences, LMU Munich, Oberschleissheim 85764, Germany., Lange A; Chair for Molecular Animal Breeding and Biotechnology, Gene Center and Department of Veterinary Sciences, LMU Munich, Munich 81377, Germany.; Center for Innovative Medical Models, Department of Veterinary Sciences, LMU Munich, Oberschleissheim 85764, Germany., Stöckl JB; Laboratory for Functional Genome Analysis, Gene Center, LMU Munich, Munich 81377, Germany., Jaudas F; Chair for Molecular Animal Breeding and Biotechnology, Gene Center and Department of Veterinary Sciences, LMU Munich, Munich 81377, Germany.; Center for Innovative Medical Models, Department of Veterinary Sciences, LMU Munich, Oberschleissheim 85764, Germany., Laane L; Chair for Molecular Animal Breeding and Biotechnology, Gene Center and Department of Veterinary Sciences, LMU Munich, Munich 81377, Germany.; Center for Innovative Medical Models, Department of Veterinary Sciences, LMU Munich, Oberschleissheim 85764, Germany., Kurome M; Chair for Molecular Animal Breeding and Biotechnology, Gene Center and Department of Veterinary Sciences, LMU Munich, Munich 81377, Germany.; Center for Innovative Medical Models, Department of Veterinary Sciences, LMU Munich, Oberschleissheim 85764, Germany., Keßler B; Chair for Molecular Animal Breeding and Biotechnology, Gene Center and Department of Veterinary Sciences, LMU Munich, Munich 81377, Germany.; Center for Innovative Medical Models, Department of Veterinary Sciences, LMU Munich, Oberschleissheim 85764, Germany., Zakhartchenko V; Chair for Molecular Animal Breeding and Biotechnology, Gene Center and Department of Veterinary Sciences, LMU Munich, Munich 81377, Germany.; Center for Innovative Medical Models, Department of Veterinary Sciences, LMU Munich, Oberschleissheim 85764, Germany., Bähr A; Center for Innovative Medical Models, Department of Veterinary Sciences, LMU Munich, Oberschleissheim 85764, Germany.; Klinik und Poliklinik für Innere Medizin I, Klinikum rechts der Isar, Technical University Munich, Munich 81675, Germany., Klymiuk N; Center for Innovative Medical Models, Department of Veterinary Sciences, LMU Munich, Oberschleissheim 85764, Germany.; Klinik und Poliklinik für Innere Medizin I, Klinikum rechts der Isar, Technical University Munich, Munich 81675, Germany., Nagashima H; Meiji University International Institute for Bio-Resource Research, Kawasaki 214-8571, Japan., Walter MC; Department of Neurology, Friedrich Baur Institute, LMU Munich, Munich 80336, Germany., Wurst W; Institute of Developmental Genetics, Helmholtz Munich, Neuherberg 85674, Germany.; Chair of Developmental Genetics, TUM School of Life Sciences, Technische Universität München, Freising 85354, Germany., Kupatt C; Klinik und Poliklinik für Innere Medizin I, Klinikum rechts der Isar, Technical University Munich, Munich 81675, Germany.; German Center for Cardiovascular Research, Munich Heart Alliance, Munich 81675, Germany., Fröhlich T; Laboratory for Functional Genome Analysis, Gene Center, LMU Munich, Munich 81377, Germany., Wolf E; Chair for Molecular Animal Breeding and Biotechnology, Gene Center and Department of Veterinary Sciences, LMU Munich, Munich 81377, Germany.; Center for Innovative Medical Models, Department of Veterinary Sciences, LMU Munich, Oberschleissheim 85764, Germany.; Laboratory for Functional Genome Analysis, Gene Center, LMU Munich, Munich 81377, Germany.; Interfaculty Center for Endocrine and Cardiovascular Disease Network Modelling and Clinical Transfer, LMU Munich, Munich 81377, Germany.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2023 Jul 18; Vol. 120 (29), pp. e2301250120. Date of Electronic Publication: 2023 Jul 10.

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