Výsledky vyhledávání - "Shashidhar Joshi"

Akademický článek

Anti-inflammatory duration of action of fluticasone furoate/vilanterol trifenatate in asthma: a cross-over randomised controlled trial

Autor: George Bardsley, Peter Daley-Yates, Amanda Baines, Rodger Kempsford, Mathew Williams, Tony Mallon, Irene Braithwaite, Kylie Riddell, Shashidhar Joshi, Philippe Bareille, Richard Beasley, James Fingleton, on behalf of the study team

Publikováno v: Respiratory Research, Vol 19, Iss 1, Pp 1-11 (2018)

Abstract Background Fluticasone furoate/Vilanterol trifenatate (FF/VI) is an inhaled corticosteroid/long-acting beta-agonist combination with a prolonged bronchodilator duration of action. We characterised the time-course of onset and offset of airwa

Externí odkaz: https://doaj.org/article/0ea8d756e76c4259b19588bbbb114934

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Effects of Low- and High-Mineral Content Water on the Relative Bioavailability of a Coformulated Abacavir/Dolutegravir/Lamivudine Dispersible Tablet in Healthy Adults

Autor: Trevor Shreeves, Nancy Skoura, Shashidhar Joshi, Ann M. Buchanan, Jafar Sadik Shaik, Linda N. Casillas, Rajendra P. Singh

Publikováno v: Journal of Acquired Immune Deficiency Syndromes (1999)

Supplemental Digital Content is Available in the Text.
Background: The fixed-dose combination (FDC) tablet formulation of abacavir/dolutegravir/lamivudine is indicated for the treatment of HIV-1 infection in adults and pediatric patients weighin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::350249f81c8f84800780bbe9c1a32650
https://doi.org/10.1097/qai.0000000000001859

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Bioequivalence of a Fixed-Dose Combination Tablet of the Complete Two-Drug Regimen of Dolutegravir and Rilpivirine for Treatment of HIV-1 Infection

Autor: Naomi Givens, Kimberly K. Adkison, Caifeng Fu, Herta Crauwels, Kristin Di Lullo, Rashmi Mehta, Simon Vanveggel, Shashidhar Joshi, Allen Wolstenholme, Brian Wynne

Publikováno v: Antimicrobial Agents and Chemotherapy. 62

A complete 2-drug regimen of dolutegravir at 50 mg and rilpivirine at 25 mg was approved to treat HIV-1 infection in virologically suppressed patients after demonstrating acceptable efficacy and tolerability. This study investigated the bioequivalenc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::197ac7a3ea5eac3b81cb26ce17e1855d
https://doi.org/10.1128/aac.00748-18

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Assessing Colonic Exposure, Safety, and Clinical Activity of SRT2104, a Novel Oral SIRT1 Activator, in Patients with Mild to Moderate Ulcerative Colitis

Autor: Ethan Hoffmann, Johannes M. Freudenberg, Jonathan Haddad, Stewart W. McCallum, Shashidhar Joshi, Deepa Elizabeth Oommen, Eric W. Jacobson, Bruce E. Sands

Publikováno v: Inflammatory Bowel Diseases

Article first published online 23 November 2015.
Background: Sirtuins are a class of proteins with important physiologic roles in metabolism and inflammation. Sirtuin (silent mating type information regulation 2 homolog) 1, or SIRT1, activation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcd1b956779bfec6af24f213ebbc63c2
http://europepmc.org/articles/PMC4885523

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The relative bioavailability of 2 prototype fixed-dose combination formulations for amlodipine and rosuvastatin in healthy white and Chinese subjects

Autor: Jonathan Bullman, Shashidhar Joshi, Shiva G. Kapsi, Htar H. Nwe, Annie Stylianou

Publikováno v: Clinical Pharmacology in Drug Development. 5:131-140

A fixed-dose combination (FDC) may improve patient compliance and clinical outcomes in the management of cardiovascular risk in hypertensive and dyslipidemic patients. The study (NCT02075619) evaluated the bioavailability of 2 prototype FDC tablet fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2ff5a713f6b3c2f4c404079526d81f37
https://doi.org/10.1002/cpdd.214

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Late Breaking Abstract - The duration of anti-inflammatory action of fluticasone furoate (FF) assessed via exhaled nitric oxide (FeNO) in asthmatics following administration of FF/vilanterol (VI)

Autor: Shashidhar Joshi, Kylie Riddell, Richard Beasley, George Bardsley, Amanda Baines, Philippe Bareille, James Fingleton, Peter T. Daley-Yates

Publikováno v: Airway Pharmacology and Treatment.

FF is an inhaled corticosteroid (ICS) with higher glucocorticoid receptor (GR) affinity and greater lung retention compared to other ICS. We investigated whether these attributes confer a prolonged duration of anti-inflammatory action. This was a ran

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3e3693aef01970d9d481acaafbf70c89
https://doi.org/10.1183/1393003.congress-2017.oa276

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Pharmacokinetic Comparison of a Unit Dose Dry Powder Inhaler with a Multidose Dry Powder Inhaler for Delivery of Fluticasone Furoate

Autor: Shashidhar Joshi, Robert Chan, Kylie Riddell, Alison Moore, Rashmi Mehta

Publikováno v: Journal of aerosol medicine and pulmonary drug delivery. 30(5)

The unit dose dry powder inhaler (UD-DPI) is being considered as an alternative inhaler platform that, if developed, has the potential to improve access to inhaled respiratory medicines in developing countries.This study compared the systemic exposur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b84a20e8ee8a134015fbf6a93e3bf61
https://pubmed.ncbi.nlm.nih.gov/28463040

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Pharmacokinetics of Salbutamol Delivered from the Unit Dose Dry Powder Inhaler: Comparison with the Metered Dose Inhaler and Diskus Dry Powder Inhaler

Autor: Kylie Riddell, Shashidhar Joshi, Rashmi Mehta, Alison Moore, Robert Chan

Publikováno v: Journal of aerosol medicine and pulmonary drug delivery. 30(3)

To compare the systemic exposure of salbutamol following delivery from the unit dose dry powder inhaler (UD-DPI) system with that from the DiskusThis open-label, two-part, six-way crossover, randomized single-dose study in healthy subjects evaluated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e322188d4648fad2c3572ddb2933613
https://pubmed.ncbi.nlm.nih.gov/28170282

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Pharmacokinetic and Bioequivalence Studies of a Newly Developed Branded Generic of Candesartan Cilexetil Tablets in Healthy Volunteers

Autor: Shashidhar Joshi, Rajesh Patel, Florencia Esquivel, Jonathan L. Palmer, Alejandro Di Ció Gimena

Publikováno v: Clinical pharmacology in drug development. 6(5)

Two bioavailability/bioequivalence studies were carried out to evaluate the pharmacokinetics of candesartan cilexetil 16mg tablet formulations. A pilot study was used to optimise the formulation and manufacturing process prior to conducting the defin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d9a4ed525de77c07c2603967dd38dd4
https://pubmed.ncbi.nlm.nih.gov/27753282

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