Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Shashi A. Gujar"'
Autor:
Barry E. Kennedy, Michael Giacomantonio, J. Patrick Murphy, Samuel Cutler, Maryanne Sadek, Prathyusha Konda, Joao A. Paulo, Gopal P. Pathak, Saskia H.J. Renkens, Stacy Grieve, Jonathan Pol, Steven P. Gygi, Christopher Richardson, Daniel Gaston, Anthony Reiman, Guido Kroemer, Manal O. Elnenaei, Shashi A. Gujar
Publikováno v:
Molecular Therapy: Oncolytics, Vol 24, Iss , Pp 695-706 (2022)
Cancer cell energy metabolism plays an important role in dictating the efficacy of oncolysis by oncolytic viruses. To understand the role of multiple myeloma metabolism in reovirus oncolysis, we performed semi-targeted mass spectrometry-based metabol
Externí odkaz:
https://doaj.org/article/bb8aca67d04a4d08ab5cbfd23667f48e
Autor:
Jordan R. Warford, Anna-Claire Lamport, Derek R. Clements, Alicia Malone, Barry E. Kennedy, Youra Kim, Shashi A. Gujar, David W. Hoskin, Alexander S. Easton
Publikováno v:
Acta Neuropathologica Communications, Vol 6, Iss 1, Pp 1-21 (2018)
Abstract Proteoglycans are promising therapeutic targets in Multiple Sclerosis (MS), because they regulate many aspects of the immune response. This was studied using surfen, an agent that binds both heparan sulphate proteoglycans (HSPGs) and chondro
Externí odkaz:
https://doaj.org/article/798f961447a743bb8b54f75ac1c7b25a
Supplementary Figures 1-6 from Reovirus Virotherapy Overrides Tumor Antigen Presentation Evasion and Promotes Protective Antitumor Immunity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6e89034d28f90f4c3b90447a2c75890
https://doi.org/10.1158/1535-7163.22484678
https://doi.org/10.1158/1535-7163.22484678
Tumor-associated immunosuppressive strategies, such as lack of tumor antigen recognition and failure of lymphocyte activation and homing, resist the development of tumor-specific immunity and hamper the immune response–mediated elimination of cance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ec37dfc54cf1bd7c0ab8311efc6b176
https://doi.org/10.1158/1535-7163.c.6531527
https://doi.org/10.1158/1535-7163.c.6531527
Autor:
Youra Kim, Derek R. Clements, Andra M. Sterea, Hyun Woo Jang, Shashi A. Gujar, Patrick W. K. Lee
Publikováno v:
Viruses, Vol 7, Iss 12, Pp 6506-6525 (2015)
Dendritic cells (DCs) are specialized antigen-presenting cells that have a notable role in the initiation and regulation of innate and adaptive immune responses. In the context of cancer, appropriately activated DCs can induce anti-tumor immunity by
Externí odkaz:
https://doaj.org/article/9f69fbecf0984086a83a944b47b828f1
Autor:
Shashi Ashok Gujar, Patrick eLee
Publikováno v:
Frontiers in Oncology, Vol 4 (2014)
Anti-tumor immunity can eliminate existing cancer cells and also maintain a constant surveillance against possible relapse. Such an antigen-specific adaptive response begins when tumor-specific T cells become activated. T cell activation requires two
Externí odkaz:
https://doaj.org/article/071d7fc71d594ce1836cf846b82a1dfd
Publikováno v:
Trends in cancer. 6(1)
Antibodies targeting CD38, a NAD
Autor:
Adil, Mohamed, Derek R, Clements, Shashi A, Gujar, Patrick W, Lee, James R, Smiley, Maya, Shmulevitz
Publikováno v:
J Virol
Little is known about how genetic variations in viruses affect their success as therapeutic agents. The type 3 Dearing strain of Mammalian orthoreovirus (T3D) is undergoing clinical trials as an oncolytic virotherapy. Worldwide, studies on reovirus o
Autor:
Mohammad, Sultan, Dejan, Vidovic, Arianne S, Paine, Thomas T, Huynh, Krysta M, Coyle, Margaret L, Thomas, Brianne M, Cruickshank, Cheryl A, Dean, Derek R, Clements, Youra, Kim, Kristen, Lee, Shashi A, Gujar, Ian C G, Weaver, Paola, Marcato
Publikováno v:
Stem cells (Dayton, Ohio). 36(5)
Avoiding detection and destruction by immune cells is key for tumor initiation and progression. The important role of cancer stem cells (CSCs) in tumor initiation has been well established, yet their ability to evade immune detection and targeting is
Autor:
Barry E, Kennedy, Tanveer, Sharif, Emma, Martell, Cathleen, Dai, Youra, Kim, Patrick W K, Lee, Shashi A, Gujar
Publikováno v:
Pharmacological research. 114
Nicotinamide adenine dinucleotide (NAD