Zobrazeno 1 - 10
of 106
pro vyhledávání: '"Shashi, Gujar"'
Publikováno v:
OncoImmunology, Vol 13, Iss 1 (2024)
CD38, a multifunctional enzyme involved in NAD+ catabolism, is hypothesized to act as a metabolic checkpoint for antitumor CD8 T cells. A recent study discovered that, apart from its direct metabolic mechanisms, CD38-mediated RyR2-AKT-TCF1 signaling
Externí odkaz:
https://doaj.org/article/c4fc461681534ec0a1900f57b505c952
Autor:
Namit Holay, Barry E. Kennedy, J. Patrick Murphy, Prathyusha Konda, Michael Giacomantonio, Tatjana Brauer-Chapin, Joao A. Paulo, Vishnupriyan Kumar, Youra Kim, Mariam Elaghil, Gary Sisson, Derek Clements, Christopher Richardson, Steven P. Gygi, Shashi Gujar
Publikováno v:
Frontiers in Immunology, Vol 13 (2023)
CD8 T cells play a central role in antiviral immunity. Type I interferons are among the earliest responders after virus exposure and can cause extensive reprogramming and antigen-independent bystander activation of CD8 T cells. Although bystander act
Externí odkaz:
https://doaj.org/article/43247c5da956443a994817e22e2a9b5e
Autor:
Shekoufeh Almasi, Clara Yu Long, Andra Sterea, Derek Richard Clements, Shashi Gujar, Yassine El Hiani
Publikováno v:
Cellular Physiology and Biochemistry, Vol 52, Iss 4, Pp 742-757 (2019)
Externí odkaz:
https://doaj.org/article/309bd322c8a649cf8377f520de8627bc
Publikováno v:
Heliyon, Vol 7, Iss 2, Pp e06155- (2021)
Aims: SARS-CoV-2, an infectious agent behind the ongoing COVID-19 pandemic, induces high levels of cytokines such as IL-1, IL-2, IL-4, IL-6, IL-10, TNF-α, IFN-γ etc in infected individuals that play a role in the underlying patho-physiology. Noneth
Externí odkaz:
https://doaj.org/article/bd68f58974b74457a8d9e8f99e83e74d
Autor:
Prathyusha Konda, Liubov M. Lifshits, John A. Roque, Houston D. Cole, Colin G. Cameron, Sherri A. McFarland, Shashi Gujar
Publikováno v:
OncoImmunology, Vol 10, Iss 1 (2021)
We report a new class of ruthenium (Ru)-based photosensitizers that induce potent cytotoxicity in melanoma cells following activation with NIR light. In addition to the direct cytotoxic effect, this Ru-based photodynamic therapy induces immunogenic c
Externí odkaz:
https://doaj.org/article/cd53397beefa46e8a7d7ee5b20571408
Autor:
Adil Mohamed, Prathyusha Konda, Heather E Eaton, Shashi Gujar, James R Smiley, Maya Shmulevitz
Publikováno v:
PLoS Pathogens, Vol 16, Iss 9, p e1008803 (2020)
The Dearing isolate of Mammalian orthoreovirus (T3D) is a prominent model of virus-host relationships and a candidate oncolytic virotherapy. Closely related laboratory strains of T3D, originating from the same ancestral T3D isolate, were recently fou
Externí odkaz:
https://doaj.org/article/3a7b10fcfd1c4abc9371650092406963
Publikováno v:
OncoImmunology, Vol 9, Iss 1 (2020)
The COVID-19 pandemic has afflicted most countries on the planet. As a result, immunity against SARS-CoV-2, induced via natural infections or imminent vaccinations, is expected to develop in a large fraction of the global population. Here, we propose
Externí odkaz:
https://doaj.org/article/c7c12c8b2d56415db3943ce5baa310fe
Autor:
Jonathan G. Pol, Sarah Lévesque, Samuel T. Workenhe, Shashi Gujar, Fabrice Le Boeuf, Derek R. Clements, Jean-Eudes Fahrner, Laetitia Fend, John C. Bell, Karen L. Mossman, Jitka Fucikova, Radek Spisek, Laurence Zitvogel, Guido Kroemer, Lorenzo Galluzzi
Publikováno v:
OncoImmunology, Vol 7, Iss 12 (2018)
Oncolytic viruses selectively target and kill cancer cells in an immunogenic fashion, thus supporting the establishment of therapeutically relevant tumor-specific immune responses. In 2015, the US Food and Drug Administration (FDA) approved the oncol
Externí odkaz:
https://doaj.org/article/03d12639f3c548f790926fb8e9abd49a
Autor:
Shashi Gujar, Yassine El Hiani, Michael A. Giacomantonio, Gopal P. Pathak, Youra Kim, Namit Holay, Prathyusha Konda, Derek R. Clements, John Patrick Murphy, Barry E. Kennedy
Oncolytic viruses (OV) such as reovirus preferentially infect and kill cancer cells. Thus, the mechanisms that dictate the susceptibility of cancer cells to OV-induced cytotoxicity hold the key to their success in clinics. Here, we investigated wheth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1f851798f8be89f8b7de8621f0d9e167
https://doi.org/10.1158/0008-5472.c.6510912.v1
https://doi.org/10.1158/0008-5472.c.6510912.v1
Autor:
Shashi Gujar, Sheila K. Singh, Paola Marcato, Carman A. Giacomantonio, Minomi Subapanditha, Chitra Venugopal, Barry E. Kennedy, Patrick J. Murphy, Mark Robert Hanes, Mohammad Saleh Ghassemi-Rad, Emma Martell, Cathleen Dai, Tanveer Sharif
Purpose:Stem-like cancer cells, with characteristic self-renewal abilities, remain highly refractory to various clinical interventions. As such, stemness-inhibiting entities, such as tumor suppressor p53, are therapeutically pursued for their antican
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c44403ff8b861b7924f1922a76aca4d8
https://doi.org/10.1158/1078-0432.c.6528539.v1
https://doi.org/10.1158/1078-0432.c.6528539.v1