Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Shashank Dadsena"'
Autor:
Shashank Dadsena, Rodrigo Cuevas Arenas, Gonçalo Vieira, Susanne Brodesser, Manuel N. Melo, Ana J. García-Sáez
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract BAX and BAK are proapoptotic members of the BCL2 family that directly mediate mitochondrial outer membrane permeabilition (MOMP), a central step in apoptosis execution. However, the molecular architecture of the mitochondrial apoptotic pore
Externí odkaz:
https://doaj.org/article/2bee97a155664393b38bf835ce663f24
Autor:
Shashank Dadsena, Svenja Bockelmann, John G. M. Mina, Dina G. Hassan, Sergei Korneev, Guilherme Razzera, Helene Jahn, Patrick Niekamp, Dagmar Müller, Markus Schneider, Fikadu G. Tafesse, Siewert J. Marrink, Manuel N. Melo, Joost C. M. Holthuis
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Ceramides are lipids that act directly on mitochondria to trigger apoptosis, but the underlying mechanism remains largely unclear. Here authors use a photoactivatable ceramide probe combined with a computation approach and functional studies to ident
Externí odkaz:
https://doaj.org/article/161032635f8246f6afb463a1fd58d74b
Publikováno v:
Molecular Cell. 83:843-856
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e8614fe7cf10f2ecf0a8da8e3324fea2
https://doi.org/10.1016/j.molcel.2023.02.021
https://doi.org/10.1016/j.molcel.2023.02.021
Publikováno v:
Cellular and Molecular Life Sciences
Apoptotic cell death is essential for development, immune function or tissue homeostasis, and its mis-regulation is linked to various diseases. Mitochondrial outer membrane permeabilization (MOMP) is a central event in the intrinsic apoptotic pathway
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f72b9cc4cabb7e0a4470d199f71f3046
http://europepmc.org/articles/PMC8106609
http://europepmc.org/articles/PMC8106609
Publikováno v:
FEBS Letters. 594:3739-3750
Mitochondrial translocation of ceramides triggers Bax-dependent apoptosis. To elucidate how ceramides activate Bax and commit cells to death, we developed a switchable version of the ceramide transfer protein CERT, sCERT. Upon its drug-induced recrui
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::075f7459e9d599d9368bd63acc704a22
https://doi.org/10.1002/1873-3468.13956
https://doi.org/10.1002/1873-3468.13956
Publikováno v:
Cell Stress
Ceramides are central intermediates of sphingolipid metabolism that can activate a variety of tumor suppressive cellular programs, including cell cycle arrest, senescence and apoptosis. Indeed, perturbations in ceramide generation and turnover are fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2c563eb425bc54866d0c28060feb2ff
https://doi.org/10.15698/cst2019.08.196
https://doi.org/10.15698/cst2019.08.196
Publikováno v:
Biochimica et Biophysica Acta (BBA)-Biomembranes
Mitochondrial outer membrane permeabilization (MOMP) is a key checkpoint in apoptosis that activates the caspase cascade and irreversibly causes the majority of cells to die. The proteins of the Bcl-2 family are master regulators of apoptosis that fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f51dde504acdf64f9fd551fac84080a
Autor:
Katia Cosentino, Vanessa Hertlein, Andreas Jenner, Timo Dellmann, Milos Gojkovic, Aida Peña-Blanco, Shashank Dadsena, Noel Wajngarten, John S.H. Danial, Jervis Vermal Thevathasan, Markus Mund, Jonas Ries, Ana J. Garcia-Saez
Publikováno v:
Molecular Cell. 82:933-949.e9
BAX and BAK are key apoptosis regulators that mediate the decisive step of mitochondrial outer membrane permeabilization. However, the mechanism by which they assemble the apoptotic pore remains obscure. Here, we report that BAX and BAK present disti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9508e1467f76dc13e240221b4d2b805a
https://doi.org/10.1016/j.molcel.2022.01.008
https://doi.org/10.1016/j.molcel.2022.01.008
Autor:
Dina G Hassan, Dagmar Müller, Patrick Niekamp, Siewert J. Marrink, Shashank Dadsena, Guilherme Razzera, Markus Schneider, Sergei Korneev, Manuel N. Melo, Joost C. M. Holthuis, John G. Mina, Helene Jahn, Svenja Bockelmann, Fikadu G. Tafesse
Publikováno v:
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Nature Communications, 10(1):1832. Nature Publishing Group
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Nature Communications, 10(1):1832. Nature Publishing Group
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Ceramides draw wide attention as tumor suppressor lipids that act directly on mitochondria to trigger apoptotic cell death. However, molecular details of the underlying mechanism are largely unknown. Using a photoactivatable ceramide probe, we here i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3790622a3c6c1797871e9a1e543de07
https://doi.org/10.1038/s41467-019-09654-4
https://doi.org/10.1038/s41467-019-09654-4
Autor:
Sujata Ghosh, Rakhee Chhetra Lalli, Kiranjeet Kaur, Anuradha Chakraborti, Shashank Dadsena, Radhika Srinivasan
Publikováno v:
Biochimie. 115
Maackia amurensis agglutinin (MAA) is gaining recognition as the potential diagnostic agent for cancer. Previous studies from our laboratory have demonstrated that this lectin could interact specifically with the cells and biopsy samples of non-small
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8685124d52e18662851329a102620e2
https://pubmed.ncbi.nlm.nih.gov/25978938
https://pubmed.ncbi.nlm.nih.gov/25978938