Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Shasad Sharif"'
Autor:
Jennifer Wang, David Trinkle, George Derbin, Kyle Martin, Shasad Sharif, Peter Timmins, Divyakant Desa
Publikováno v:
Journal of Excipients and Food Chemicals, Vol 5, Iss 1 (2016)
A bilayer tablet formulation approach was used to develop a fixed dose combination tablet formulation of drugs Y & Z. The weight of Layer I containing Drug Y and the weight of Layer II A or II B containing Drug Z were 250 mg and 1280 mg, respectively
Externí odkaz:
https://doaj.org/article/5eb7087bf7c14c2bbcef9ad49762969e
Autor:
Jinjiang Li, Swathi Pinnamaneni, Ramesh K. Ramakrishnan, Junshu Zhao, Mario Hubert, Sergei Nazarenko, Li Tao, Shasad Sharif
Publikováno v:
Journal of Pharmaceutical Sciences. 109:1050-1058
The effect of vapor sorption on the free volume of drug-polymer spray-dried dispersions (SDDs) was investigated, along with the crystallization propensity of drug molecules in SDDs after exposure to humidity. Subsequently, the correlation of free vol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b38df5ef568760a01a7a3137f2ef59d
https://doi.org/10.1016/j.xphs.2019.10.018
https://doi.org/10.1016/j.xphs.2019.10.018
Publikováno v:
International journal of pharmaceutics. 583
Controlled release tablets are important dosage forms enabling a slower release of the drug and better pharmacokinetics for some drugs and hydrophilic matrix tablets utilizing hydroxypropyl methylcellulose (HPMC) are one of the most common types. One
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35bde00b9716017e1a186a6c18f88c62
https://pubmed.ncbi.nlm.nih.gov/32305364
https://pubmed.ncbi.nlm.nih.gov/32305364
Autor:
Divyakant Desai, Hang Guo, Dan Tang, Umesh S. Kestur, Shasad Sharif, Benjamin Wong, Steven H. Chan
Publikováno v:
Pharmaceutical Development and Technology. 22:715-723
During the development of a wet granulated 850 mg metformin hydrochloride tablet formulation, the tablets exhibited high friability (>3% w/w) irrespective of the source of extra-granular magnesium stearate (MgSt). High friability values indicated tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acc3b010c4be3dedfa29de181e7412bc
https://doi.org/10.3109/10837450.2015.1116562
https://doi.org/10.3109/10837450.2015.1116562
Publikováno v:
Advanced Powder Technology. 26:337-348
It can be difficult to accurately measure true density of low bulk density materials, which are frequently used in drug products. This was demonstrated on a crystalline model API. Uncertainty was related to insufficient sample volume. The error funct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8fbfd219b0483d9f7bf2187a29022d86
https://doi.org/10.1016/j.apt.2014.11.002
https://doi.org/10.1016/j.apt.2014.11.002
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 1848:363-368
The peptidoglycan of Gram-positive bacteria consists of glycan chains with attached short peptide stems cross-linked to one another by glycyl bridges. The bridge of Staphylococcus aureus has five glycyl units and that of its FemA mutant has one. Thes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::841772bea5545af0666c120c21c1554b
https://doi.org/10.1016/j.bbamem.2014.05.025
https://doi.org/10.1016/j.bbamem.2014.05.025
We have used solid-state nuclear magnetic resonance to characterize the exact nature of the dual mode of action of oritavancin in preventing cell-wall assembly in Staphylococcus aureus. Measurements performed on whole cells labeled selectively in viv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51049d5da77120f9f060ba41f2f0b543
https://europepmc.org/articles/PMC5508972/
https://europepmc.org/articles/PMC5508972/
Publikováno v:
Biochemistry
Staphylococcus aureus FemA mutant grown in the presence of an alanine-racemase inhibitor was labeled with d-[1-(13)C]alanine, l-[3-(13)C]alanine, [2-(13)C]glycine, and l-[5-(19)F]lysine to characterize some details of the peptidoglycan tertiary struc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a62f0bf52204d3e2be389575f4d2d0d2
https://doi.org/10.1021/bi4016742
https://doi.org/10.1021/bi4016742
Autor:
Reinhard Zander, Emily J. Fogle, Alexandra Dos, Monique Chan-Huot, Ilya G. Shenderovich, Peter M. Tolstoy, Gleb S. Denisov, Shasad Sharif, Shara Compton, Hans-Heinrich Limbach, Michael D. Toney
Publikováno v:
Journal of the American Chemical Society. 135:18160-18175
Using (15)N solid-state NMR, we have studied protonation and H-bonded states of the cofactor pyridoxal 5'-phosphate (PLP) linked as an internal aldimine in alanine racemase (AlaR), aspartate aminotransferase (AspAT), and poly-L-lysine. Protonation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c539ac6675c3cf8457bb5cf902d0e9c3
https://doi.org/10.1021/ja408988z
https://doi.org/10.1021/ja408988z
Autor:
Shruti Gour, Christopher Levins, Brian M. Zacour, Howard J. Stamato, Preetanshu Pandey, Steve Pafiakis, David Buckley, Shasad Sharif, Dilbir S. Bindra, Jade Trinh
Publikováno v:
Pharmaceutical development and technology. 23(6)
The objective of this study was to improve the disintegration and dissolution characteristics of a highly water-soluble tablet matrix by altering the manufacturing process. A high disintegration time along with high dependence of the disintegration t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e76e303fea317656dab72be4762ca19b
https://pubmed.ncbi.nlm.nih.gov/27879156
https://pubmed.ncbi.nlm.nih.gov/27879156