Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Sharyn Leanne Bayne"'
Publikováno v:
Annals of the New York Academy of Sciences. 1114:48-55
Estrogen regulates tissue development, function, and aging by regulating expression of critical genes. Recent studies suggest that estrogen promotes cell proliferation by stimulating telomerase activity, an enzyme that plays a key role in extending c
Publikováno v:
Cancer research. 68(22)
Telomere maintenance is critical in tumor cell immortalization. Here, we report that the cytokine bone morphogenetic protein-7 (BMP7) inhibits telomerase activity that is required for telomere maintenance in cervical cancer cells. Application of huma
Autor:
Sharyn Leanne Bayne, Evan R. Simpson, Alexander R. Pinto, He Li, Jun-Ping Liu, Margaret E. E. Jones
Publikováno v:
Cell research. 18(11)
Estrogen deficiency mediates aging, but the underlying mechanism remains to be fully determined. We report here that estrogen deficiency caused by targeted disruption of aromatase in mice results in significant inhibition of telomerase activity in th
Publikováno v:
The FASEB Journal. 21
Autor:
Sharyn Leanne Bayne, Jun-Ping Liu
Publikováno v:
Molecular and cellular endocrinology. 240(1-2)
Telomerase is a specialised reverse transcriptase that synthesises and preserves telomeres (the ends of chromosomes), thereby playing a key role in regulating the lifespan of cell proliferation. Telomerase activity is critically involved in cell deve