Zobrazeno 1 - 10
of 125
pro vyhledávání: '"Sharyn I. Katz"'
KLF5 and p53 comprise an incoherent feed-forward loop directing cell-fate decisions following stress
Autor:
Yizeng Yang, Dharmendra Bhargava, Xiao Chen, Taicheng Zhou, Gizem Dursuk, Wenpeng Jiang, Jinshen Wang, Zhen Zong, Sharyn I. Katz, Gwen A. Lomberk, Raul A. Urrutia, Jonathan P. Katz
Publikováno v:
Cell Death and Disease, Vol 14, Iss 5, Pp 1-10 (2023)
Abstract In response to stress, cells make a critical decision to arrest or undergo apoptosis, mediated in large part by the tumor suppressor p53. Yet the mechanisms of these cell fate decisions remain largely unknown, particularly in normal cells. H
Externí odkaz:
https://doaj.org/article/ec7f0cfa3b1b4e0b99fa62ec85368f3d
Autor:
Apurva Singh, Hannah Horng, Rhea Chitalia, Leonid Roshkovan, Sharyn I. Katz, Peter Noël, Russell T. Shinohara, Despina Kontos
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Our study investigates the effects of heterogeneity in image parameters on the reproducibility of prognostic performance of models built using radiomic biomarkers. We compare the prognostic performance of models derived from the heterogeneit
Externí odkaz:
https://doaj.org/article/0557f9b57c4146a18d58a007de5838e6
Autor:
Apurva Singh, Hannah Horng, Leonid Roshkovan, Joanna K. Weeks, Michelle Hershman, Peter Noël, José Marcio Luna, Eric A. Cohen, Lauren Pantalone, Russell T. Shinohara, Joshua M. Bauml, Jeffrey C. Thompson, Charu Aggarwal, Erica L. Carpenter, Sharyn I. Katz, Despina Kontos
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract We aim to determine the feasibility of a novel radiomic biomarker that can integrate with other established clinical prognostic factors to predict progression-free survival (PFS) in patients with non-small cell lung cancer (NSCLC) undergoing
Externí odkaz:
https://doaj.org/article/56ec5c56ca4341e8ac7babf7c546c3c5
Autor:
Bardia Yousefi, Michael J. LaRiviere, Eric A. Cohen, Thomas H. Buckingham, Stephanie S. Yee, Taylor A. Black, Austin L. Chien, Peter Noël, Wei-Ting Hwang, Sharyn I. Katz, Charu Aggarwal, Jeffrey C. Thompson, Erica L. Carpenter, Despina Kontos
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Among non-small cell lung cancer (NSCLC) patients with therapeutically targetable tumor mutations in epidermal growth factor receptor (EGFR), not all patients respond to targeted therapy. Combining circulating-tumor DNA (ctDNA), clinical var
Externí odkaz:
https://doaj.org/article/2bc9f76cb0c2446eb992e36476f5b7bf
Autor:
José Marcio Luna, Hann-Hsiang Chao, Russel T. Shinohara, Lyle H. Ungar, Keith A. Cengel, Daniel A. Pryma, Chidambaram Chinniah, Abigail T. Berman, Sharyn I. Katz, Despina Kontos, Charles B. Simone, II, Eric S. Diffenderfer
Publikováno v:
Clinical and Translational Radiation Oncology, Vol 22, Iss , Pp 69-75 (2020)
Background and Purpose: Radiation esophagitis is a clinically important toxicity seen with treatment for locally-advanced non-small cell lung cancer. There is considerable disagreement among prior studies in identifying predictors of radiation esopha
Externí odkaz:
https://doaj.org/article/4f9a3c1e3a2d4d608c79d2cf6344e73b
Autor:
Sharyn I. Katz, Christopher M. Straus, Leonid Roshkovan, Kevin G. Blyth, Thomas Frauenfelder, Ritu R. Gill, Ferry Lalezari, Jeremy Erasmus, Anna K. Nowak, Victor H. Gerbaudo, Roslyn J. Francis, Samuel G. Armato
Publikováno v:
Journal of Thoracic Oncology. 18:278-298
Malignant pleural mesothelioma (MPM) is an aggressive primary malignancy of the pleura that presents unique radiologic challenges with regards to accurate and reproducible assessment of disease extent at staging and follow-up imaging. By optimizing a
Autor:
Michelle Hershman, Bardia Yousefi, Lacey Serletti, Maya Galperin-Aizenberg, Leonid Roshkovan, José Marcio Luna, Jeffrey C. Thompson, Charu Aggarwal, Erica L. Carpenter, Despina Kontos, Sharyn I. Katz
Publikováno v:
Cancers, Vol 13, Iss 23, p 5985 (2021)
This study tackles interobserver variability with respect to specialty training in manual segmentation of non-small cell lung cancer (NSCLC). Four readers included for segmentation are: a data scientist (BY), a medical student (LS), a radiology train
Externí odkaz:
https://doaj.org/article/1230c50e1ea44d689db461a29315b8c6
Autor:
Dimitrios Bounias, Ashish Singh, Spyridon Bakas, Sarthak Pati, Saima Rathore, Hamed Akbari, Michel Bilello, Benjamin A. Greenberger, Joseph Lombardo, Rhea D. Chitalia, Nariman Jahani, Aimilia Gastounioti, Michelle Hershman, Leonid Roshkovan, Sharyn I. Katz, Bardia Yousefi, Carolyn Lou, Amber L. Simpson, Richard K. G. Do, Russell T. Shinohara, Despina Kontos, Konstantina Nikita, Christos Davatzikos
Publikováno v:
Applied Sciences, Vol 11, Iss 16, p 7488 (2021)
We seek the development and evaluation of a fast, accurate, and consistent method for general-purpose segmentation, based on interactive machine learning (IML). To validate our method, we identified retrospective cohorts of 20 brain, 50 breast, and 5
Externí odkaz:
https://doaj.org/article/d95d5627884f46c28ebdea628a62d1a8
Autor:
Apurva Singh, Hannah Horng, Leonid Roshkovan, Sharyn I. Katz, Despina Kontos, Jeffrey C. Thompson
Publikováno v:
Medical Imaging 2023: Computer-Aided Diagnosis.
Autor:
Chunrui Zou, Walter Mankowski, Lauren Pantalone, Shefali Setia Verma, Eduardo J. Mortani Barbosa, Tessa S. Cook, Peter B. Noel, Erica L. Carpenter, Jeffrey C. Thompson, Russell T. Shinohara, Sharyn I. Katz, Despina Kontos
Publikováno v:
Medical Imaging 2023: Computer-Aided Diagnosis.