Zobrazeno 1 - 10
of 405
pro vyhledávání: '"Sharyn D. Baker"'
Autor:
Amanda B. Kagan, Dominique A. Garrison, Nicole M. Anders, Jonathan A. Webster, Sharyn D. Baker, Srinivasan Yegnasubramanian, Michelle A. Rudek
Publikováno v:
Clinical and Translational Science, Vol 16, Iss 8, Pp 1309-1322 (2023)
Abstract Although DNA methyltransferase inhibitors (DNMTis), such as azacitidine and decitabine, are used extensively in the treatment of myelodysplastic syndromes and acute myeloid leukemia, there remain unanswered questions about DNMTi's mechanism
Externí odkaz:
https://doaj.org/article/2558cdc7ea7d4ba6b1738378115c452f
Autor:
Avinash K. Persaud, Matthew C. Bernier, Michael A. Massey, Shipra Agrawal, Tejinder Kaur, Debasis Nayak, Zhiliang Xie, Brenna Weadick, Ruchika Raj, Kasey Hill, Nicole Abbott, Arnav Joshi, Nadeen Anabtawi, Claire Bryant, Arpad Somogyi, Zobeida Cruz-Monserrate, Foued Amari, Vincenzo Coppola, Alex Sparreboom, Sharyn D. Baker, Jashvant D. Unadkat, Mitch A. Phelps, Rajgopal Govindarajan
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Concentrative nucleoside transporters (CNTs) are active nucleoside influx systems, but their in vivo roles are poorly defined. By generating CNT1 knockout (KO) mice, here we identify a role of CNT1 in the renal reabsorption of nucleosides. D
Externí odkaz:
https://doaj.org/article/bab63ae328b3450a9e6f8d180eccc7bc
Autor:
Sharyn D. Baker, William D. Figg
Publikováno v:
Clinical and Translational Science, Vol 17, Iss 1, Pp n/a-n/a (2024)
Externí odkaz:
https://doaj.org/article/420aec1fe77147a09b1a673873dbbab7
Autor:
Yang Li, Thomas Drabison, Mahesh Nepal, Richard H. Ho, Alix F. Leblanc, Alice A. Gibson, Yan Jin, Wenjian Yang, Kevin M. Huang, Muhammad Erfan Uddin, Mingqing Chen, Duncan F. DiGiacomo, Xihui Chen, Sobia Razzaq, Jeffrey R. Tonniges, Dana M. McTigue, Alice S. Mims, Maryam B. Lustberg, Yijia Wang, Amanda B. Hummon, William E. Evans, Sharyn D. Baker, Guido Cavaletti, Alex Sparreboom, Shuiying Hu
Publikováno v:
JCI Insight, Vol 8, Iss 14 (2023)
Vincristine is a widely used chemotherapeutic drug for the treatment of multiple malignant diseases that causes a dose-limiting peripheral neurotoxicity. There is no clinically effective preventative treatment for vincristine-induced sensory peripher
Externí odkaz:
https://doaj.org/article/ce9d6058dddc4a1f9ae29073d522d78d
Autor:
Avinash K. Persaud, Matthew C. Bernier, Michael A. Massey, Shipra Agrawal, Tejinder Kaur, Debasis Nayak, Zhiliang Xie, Brenna Weadick, Ruchika Raj, Kasey Hill, Nicole Abbott, Arnav Joshi, Nadeen Anabtawi, Claire Bryant, Arpad Somogyi, Zobeida Cruz-Monserrate, Foued Amari, Vincenzo Coppola, Alex Sparreboom, Sharyn D. Baker, Jashvant D. Unadkat, Mitch A. Phelps, Rajgopal Govindarajan
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/2b638685a878448bb21750b2e6773983
Autor:
Daelynn R. Buelow, Jason T. Anderson, Stanley B. Pounds, Lei Shi, Jatinder K. Lamba, Shuiying Hu, Alice A. Gibson, Emily A. Goodwin, Alex Sparreboom, Sharyn D. Baker
Publikováno v:
Clinical and Translational Science, Vol 14, Iss 1, Pp 137-142 (2021)
Reduced expression of the uptake transporter, OCTN1 (SLC22A4), has been reported as a strong predictor of poor event‐free and overall survival in multiple cohorts of patients with acute myeloid leukemia (AML) receiving the cytidine nucleoside analo
Externí odkaz:
https://doaj.org/article/60a03cb38eac4e618ecd1c78891d4e02
Autor:
Ji Young Kim, Yuntao Bai, Laura A. Jayne, Ralph D. Hector, Avinash K. Persaud, Su Sien Ong, Shreshtha Rojesh, Radhika Raj, Mei Ji He Ho Feng, Sangwoon Chung, Rachel E. Cianciolo, John W. Christman, Moray J. Campbell, David S. Gardner, Sharyn D. Baker, Alex Sparreboom, Rajgopal Govindarajan, Harpreet Singh, Taosheng Chen, Ming Poi, Katalin Susztak, Stuart R. Cobb, Navjot Singh Pabla
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Protein kinases have emerged as critical regulators of disease pathogenesis. Here, the authors have utilized kinome-wide screening approaches to reveal a pathogenic role of CDKL5 kinase in acute kidney injury, which is dependent on suppression of a S
Externí odkaz:
https://doaj.org/article/f36413dcdc0f4c47bbdac00ac1a34b20
Autor:
Ola A. Elgamal, Abeera Mehmood, Jae Yoon Jeon, Bridget Carmichael, Amy Lehman, Shelley J. Orwick, Jean Truxall, Virginia M. Goettl, Ronni Wasmuth, Minh Tran, Shaneice Mitchell, Rosa Lapalombella, Sudharshan Eathiraj, Brian Schwartz, Kimberly Stegmaier, Sharyn D. Baker, Erin Hertlein, John C. Byrd
Publikováno v:
Journal of Hematology & Oncology, Vol 13, Iss 1, Pp 1-14 (2020)
Abstract Background Acute myeloid leukemia (AML) is the most common type of adult leukemia. Several studies have demonstrated that oncogenesis in AML is enhanced by kinase signaling pathways such as Src family kinases (SFK) including Src and Lyn, spl
Externí odkaz:
https://doaj.org/article/dd45c2eb4bd348c99ba2f63a9ee816cc
Autor:
Daelynn R. Buelow, Stanley B. Pounds, Yong‐Dong Wang, Lei Shi, Yongjin Li, David Finkelstein, Sheila Shurtleff, Geoffrey Neale, Hiroto Inaba, Raul C. Ribeiro, Reid Palumbo, Dominique Garrison, Shelley J. Orwick, James S. Blachly, Karl Kroll, John C. Byrd, Tanja A. Gruber, Jeffrey E. Rubnitz, Sharyn D. Baker
Publikováno v:
Clinical and Translational Science, Vol 12, Iss 6, Pp 641-647 (2019)
Fms‐like tyrosine kinase 3 (FLT3) internal tandem duplication (ITD) mutations, common in pediatric acute myeloid leukemia (AML), associate with early relapse and poor prognosis. Past studies have suggested additional cooperative mutations are requi
Externí odkaz:
https://doaj.org/article/b729c098fb6e48d4859209165db95c5f
Autor:
Eric D. Eisenmann, Jack C. Stromatt, Sydney Fobare, Kevin M. Huang, Daelynn R. Buelow, Shelley Orwick, Jae Yoon Jeon, Robert H. Weber, Bill Larsen, Alice S. Mims, Erin Hertlein, John C. Byrd, Sharyn D. Baker
Publikováno v:
Cancers, Vol 15, Iss 1, p 29 (2022)
Acute myeloid leukemia (AML) with mutations in the tumor suppressor gene TP53 confers a dismal prognosis with 3-year overall survival of TP53 mutant cancers, this strategy has not been evaluated in mutant TP53 AML. Previously, we demonstrated that TP
Externí odkaz:
https://doaj.org/article/6cdb50eea66c4709860130c1c2084a00