Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Sharwari Verma"'
Autor:
Adam Nabeebaccus, Giulia Emanuelli, Sharwari Verma, Celio Xc. Santos, Katrin Streckfuss-Bömeke, Anna Zoccarato, Ajay M. Shah
Publikováno v:
Biochemical and Biophysical Research Communications
In response to cardiac injury, increased activity of the hexosamine biosynthesis pathway (HBP) is linked with cytoprotective as well as adverse effects depending on the type and duration of injury. Glutamine-fructose amidotransferase (GFAT; gene name
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::656c93621918c2c28e841dd25105d981
https://doi.org/10.1016/j.bbrc.2021.10.056
https://doi.org/10.1016/j.bbrc.2021.10.056
Autor:
Gian F, De Nicola, Rekha, Bassi, Charlie, Nichols, Mariana, Fernandez-Caggiano, Pelin Arabacilar, Golforoush, Dibesh, Thapa, Rhys, Anderson, Eva Denise, Martin, Sharwari, Verma, Jens, Kleinjung, Adam, Laing, Jonathan P, Hutchinson, Philip, Eaton, James, Clark, Michael S, Marber
Publikováno v:
JCI insight. 3(16)
Inhibiting MAPK14 (p38α) diminishes cardiac damage in myocardial ischemia. During myocardial ischemia, p38α interacts with TAB1, a scaffold protein, which promotes p38α autoactivation; active p38α (pp38α) then transphosphorylates TAB1. Previousl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e605d5f2e83ad8d47b505f93acf97da5
https://pubmed.ncbi.nlm.nih.gov/30135318
https://pubmed.ncbi.nlm.nih.gov/30135318
Autor:
Dibesh, Thapa, Charlie, Nichols, Rekha, Bassi, Eva Denise, Martin, Sharwari, Verma, Maria R, Conte, Vittorio, De Santis, Gian F, De Nicola, Michael S, Marber
Publikováno v:
Molecular and Cellular Biology
p38α mitogen-activated protein kinase is essential to cellular homeostasis. Two principal mechanisms to activate p38α exist. The first relies on dedicated dual-specificity kinases such as mitogen-activated protein kinase kinase (MAP2K) 3 (MKK3) or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::416907eb8e317fbe049ab366a93e33b5
https://pubmed.ncbi.nlm.nih.gov/29229647
https://pubmed.ncbi.nlm.nih.gov/29229647
Autor:
Gian Felice De Nicola, Stefan Knapp, Luigi Martino, James Clark, Eva Denise Martin, Rekha Bassi, R. Andrew Atkinson, Michael S. Marber, Apirat Chaikuad, Renée Tata, Sharwari Verma, Maria R. Conte, Pierre Sicard
Publikováno v:
Nature structural & molecular biology
Nature Structural & Molecular Biology; Vol 20
Nature Structural & Molecular Biology; Vol 20
p38α mitogen-activated protein kinase (p38α) is activated by a variety of mechanisms, including autophosphorylation initiated by TGFβ-activated kinase 1 binding protein 1 (TAB1) during myocardial ischemia and other stresses. Chemical-genetic appro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4622da0ae6322d885d0541017cbaeea
https://doi.org/10.1038/nsmb.2668
https://doi.org/10.1038/nsmb.2668
Autor:
James Clark, Sebastien Jacquet, Rekha Bassi, Michael S. Marber, Sarawut Kumphune, Stephen J. O'Keefe, Sharwari Verma, Pierre Sicard, Metin Avkiran
Publikováno v:
Journal of Biological Chemistry. 285:2968-2975
The use of nonselective pharmacological inhibitors has resulted in controversy regarding the mechanism and consequences of p38 activation during myocardial infarction. Classic p38 inhibitors such as SB203580 rely on a critical "gatekeeper" threonine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d36c36cce67e023a16f5587e356a5e54
https://doi.org/10.1074/jbc.m109.079228
https://doi.org/10.1074/jbc.m109.079228
Autor:
Gian Felice De Nicola, E D Martin, Rekha Bassi, Sharwari Verma, Maria Conte, Michael S Marber
Publikováno v:
Circulation Research. 111
Activation of p38α MAPK (p38α), by phosphorylation of two residues in the TGY motif of the activation loop, can occur independently of upstream kinases. One such mechanism involves the scaffolding protein Transforming Growth Factor-β-activated pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a57191deb4936ee86298035269c74b1e
https://doi.org/10.1161/res.111.suppl_1.a32
https://doi.org/10.1161/res.111.suppl_1.a32
Publikováno v:
Heart. 100:A8.2-A8
Activation of p38 mitogen activated protein kinase alpha during myocardial ischaemia results in myocardial damage. Identifying and targeting the relevant substrates downstream of p38alpha may potentially provide a therapeutic target to limit myocardi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9513c737f2377386464b763be0cbc942
https://doi.org/10.1136/heartjnl-2013-305297.22
https://doi.org/10.1136/heartjnl-2013-305297.22