Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Sharron Dolan"'
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0136819 (2015)
The adipose tissue-derived protein, adiponectin, has significant anti-inflammatory properties in a variety of disease conditions. Recent evidence that adiponectin and its receptors (AdipoR1 and AdipoR2) are expressed in central nervous system, sugges
Externí odkaz:
https://doaj.org/article/5208e0b8371c46049def6f9bcf397222
Publikováno v:
Bioscience of Microbiota, Food and Health. 41:195-199
Autor:
Sharron Dolan, Nasser M Alorfi
Publikováno v:
Neurology and Neurobiology. :1-8
Obesity is associated with several co-morbidities including chronic pain. Systemic low-grade chronic inflammation and dysregulation of pro-inflammatory cytokines have been proposed to underlie these phenomena. This study characterized pain and inflam
Publikováno v:
Bioscience of Microbiota, Food and Health
Various studies have suggested that the gut microbiome interacts with the host and may have a significant role in the aetiology of obesity and Type 2 Diabetes (T2D). It was hypothesised that bacterial communities in obesity and T2D differ from contro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1b7a92d04947e0a9408dc109d7d1753
https://eprints.leedsbeckett.ac.uk/id/eprint/7138/6/CharacterisationOfGutMicrobiotaOfObesityAndType2DiabetesPV-LANG.pdf
https://eprints.leedsbeckett.ac.uk/id/eprint/7138/6/CharacterisationOfGutMicrobiotaOfObesityAndType2DiabetesPV-LANG.pdf
Autor:
Sharron Dolan, Angus M. Shaw, Steven Patterson, Xinhua Shu, Erin Campbell, Chinmai Patibandla
Glucagon-like peptide 1 (GLP-1) is an incretin hormone produced in gut L-cells, which regulates postprandial glucose-dependent insulin secretion, also known as the incretin effect. GLP-1 secretion may be reduced in type 2 diabetes mellitus, impacting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1dbb04ee8a0d9ff9d3d80bd2ecf01067
https://doi.org/10.1101/2020.09.07.285916
https://doi.org/10.1101/2020.09.07.285916
Autor:
Chris Bartholomew, Steven Patterson, Poornima Roy, Mohammad Al Hasan, Patricia Martin, Sharron Dolan
Publikováno v:
Journal of cellular physiology. 235(2)
Obesity-associated conditions represent major global health and financial burdens and understanding processes regulating adipogenesis could lead to novel intervention strategies. This study shows that adhesion G-protein coupled receptor 56 (GPR56) ge
Publikováno v:
Bioscience Reports
Pancreatic β-cells are sensitive to fluctuations in cholesterol content, which can damage the insulin secretion pathway, contributing to the aetiology of type 2 diabetes mellitus. Cholesterol efflux to (apo)lipoproteins, via ATP-binding cassette (AB
Autor:
Sharron Dolan, Michelle Goldie
Publikováno v:
Behavioural Pharmacology. 24:298-306
Standardized Ginkgo biloba extract EGb 761 has been shown to inhibit inflammatory hyperalgesia in rats; however, the mechanism of action is not known. This study set out to investigate the anti-inflammatory and analgesic potential of bilobalide, a un
Publikováno v:
Experimental Physiology. 97:1236-1245
This study investigated whether sensitivity to nociceptive stimuli is altered in obese rats using established models of inflammatory pain, and using real-time PCR, profiled alterations in expression of key adipokine and inflammatory mediator mRNA (ad
Autor:
David Haigh, Miriam Sgobba, Kirsty McLaughlin, Rosemary O'Connor, Emma M. Kerr, Cathy Fenning, Joel S. Riley, P.G. Johnston, Izabela Stasik, Daniel B. Longley, Joanna Majkut, Keara Redmond, Caitriona Holohan, Sharron Dolan, Patrick A. Kiely, M. Crudden, Kirsty M. McLaughlin, S. Van Schaeybroeck
Publikováno v:
Cell Death & Differentiation. 19:1317-1327
FLIP is a potential anti-cancer therapeutic target that inhibits apoptosis by blocking caspase 8 activation by death receptors. We report a novel interaction between FLIP and the DNA repair protein Ku70 that regulates FLIP protein stability by inhibi