Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Sharpless, Barry K."'
Autor:
Prakash, Ram, Sharpless, Barry k.
Publikováno v:
Advances in Pharmacology & Toxicology. Jun2023, Vol. 24 Issue 1, preceding p1-1. 1p.
Autor:
Prakash, Ram1, Sharpless, Barry K.1
Publikováno v:
Advances in Pharmacology & Toxicology. Dec2022, Vol. 23 Issue 2, p1-1. 1p.
Autor:
Kovarik, Zrinka, Kalisiak, Jaroslaw, Maček, Nikolina, Katalinić, Maja, Berend, Suzana, Radić, Zoran, Fokin, Valery V., Sharpless, Barry K., Taylor, Palmer
The copper-catalysed azide-alkyne cycloaddition reaction enables an efficient and reliable synthesis of libraries of new oximes that were screened for the reactivation activity of tabun-inhibited human acetylcholinesterase (AChE), its mutants, and bu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=57a035e5b1ae::feda8b9f6903d52928c3c2060f7fb8e1
https://www.bib.irb.hr/601009
https://www.bib.irb.hr/601009
Autor:
Kovarik, Zrinka, Kalisiak, Jarosław, Maček, Nikolina, Katalinić, Maja, Berend, Suzana, Radić, Zoran, Fokin, Valery V., Sharpless, Barry K., Taylor, Palmer
Acetylcholinesterase (AChE, EC 3.1.1.7), an important enzyme in cholinergic neurotransmission, is the primary target of organophosphorus compounds (OP) like pesticides and nerve agents such as tabun. A library of new oximes was screened for the react
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=57a035e5b1ae::b2570a236cff90e2c53ca0ce46da42d5
https://www.bib.irb.hr/586220
https://www.bib.irb.hr/586220
Autor:
Kovarik, Zrinka, Kalisiak, Jarosław, Maček, Nikolina, Katalinić, Maja, Berend, Suzana, Radić, Zoran, Fokin, Valery V., Sharpless, Barry K., and Taylor, Palmer
The copper-catalyzed azide-alkyne cycloaddition reaction enables an efficient and reliable synthesis of libraries of new oximes that were screened for the reactivation activity of tabun-inhibited human recombinant AChE (wild type, AChE mutants Y337A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=57a035e5b1ae::e05c1d91cde99bb5793b6eec42e7e47b
https://www.bib.irb.hr/586223
https://www.bib.irb.hr/586223
Autor:
Kovarik, Zrinka, Katalinić, Maja, Maček, Nikolina, Radić, Zoran, Fokin, Valery V., Taylor, Palmer, Sharpless, Barry K.
The copper-catalyzed azide-alkyne cycloaddition reaction enabled fast and reliable synthesis of libraries of oximes that were screened for the reactivation activity of tabun-inhibited human recombinant AChE, wild type, the AChE single mutant Y337A, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=57a035e5b1ae::2ac43da08039e4648daa49ee82db5d03
https://www.bib.irb.hr/550463
https://www.bib.irb.hr/550463
Autor:
Kovarik, Zrinka, Čalić, Maja, Kalisiak, Jaroslaw, Radić, Zoran, Taylor, Palmer, Fokin, Valery V., Sharpless, Barry K.
Application of the [3+2] cycloaddition reaction between alkynes and azides (“ Click reaction” ) as a combinatorial approach allows for the fast and reliable synthesis of libraries of new reactivators that were screened toward reactivation of tabu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=57a035e5b1ae::bce7bfa4a349fa8c28de9e512302d9ca
https://www.bib.irb.hr/334126
https://www.bib.irb.hr/334126
Autor:
Kalisiak, Jaroslaw, Radić, Zoran, Zhang, Limin, Kovarik, Zrinka, Čalić, Maja, Taylor, Palmer, Fokin, Valery V., Sharpless, Barry K.
Organophosphorus pesticides (e.g. Parathion, Chlorpyrifos) and chemical warfare nerve agents (e.g. Sarin, Tabun, VX) are potent irreversible inhibitors of synaptic AChE, causing cholinergic overstimulation and death due to respiratory system failure.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=57a035e5b1ae::e743b2b38408031817ea644760a392f5
https://www.bib.irb.hr/375691
https://www.bib.irb.hr/375691
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Akademický článek
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