The small molecule CLP257 does not modify activity of the K ⁺ -Cl ^- co-transporter KCC2 but does potentiate GABA A receptor activity.

Autor: Cardarelli RA; AstraZeneca Tufts Laboratory for Basic and Translational Neuroscience, Boston, Massachusetts, USA., Jones K; Discovery Sciences, IMED Biotech Unit, AstraZeneca, Alderley Park, UK., Pisella LI; INMED, INSERM, Unité 901, Marseille, France.; Aix-Marseille Université, UMR 901, Marseille, France., Wobst HJ; AstraZeneca Tufts Laboratory for Basic and Translational Neuroscience, Boston, Massachusetts, USA.; Neuroscience, IMED Biotech Unit, AstraZeneca, Boston, Massachusetts, USA., McWilliams LJ; Discovery Sciences, IMED Biotech Unit, AstraZeneca, Cambridge, UK., Sharpe PM; Discovery Sciences, IMED Biotech Unit, AstraZeneca, Alderley Park, UK., Burnham MP; Discovery Sciences, IMED Biotech Unit, AstraZeneca, Alderley Park, UK., Baker DJ; Discovery Sciences, IMED Biotech Unit, AstraZeneca, Cambridge, UK., Chudotvorova I; INMED, INSERM, Unité 901, Marseille, France.; Aix-Marseille Université, UMR 901, Marseille, France., Guyot J; INMED, INSERM, Unité 901, Marseille, France.; Aix-Marseille Université, UMR 901, Marseille, France., Silayeva L; AstraZeneca Tufts Laboratory for Basic and Translational Neuroscience, Boston, Massachusetts, USA., Morrow DH; Department of Neuroscience, Tufts University School of Medicine, Boston, Massachusetts, USA., Dekker N; Discovery Sciences, IMED Biotech Unit, AstraZeneca, Gothenburg, Sweden., Zicha S; Neuroscience, IMED Biotech Unit, AstraZeneca, Boston, Massachusetts, USA., Davies PA; Department of Neuroscience, Tufts University School of Medicine, Boston, Massachusetts, USA., Holenz J; Neuroscience, IMED Biotech Unit, AstraZeneca, Boston, Massachusetts, USA., Duggan ME; Neuroscience, IMED Biotech Unit, AstraZeneca, Boston, Massachusetts, USA., Dunlop J; Neuroscience, IMED Biotech Unit, AstraZeneca, Boston, Massachusetts, USA., Mather RJ; Neuroscience, IMED Biotech Unit, AstraZeneca, Boston, Massachusetts, USA., Wang Q; AstraZeneca Tufts Laboratory for Basic and Translational Neuroscience, Boston, Massachusetts, USA.; Neuroscience, IMED Biotech Unit, AstraZeneca, Boston, Massachusetts, USA., Medina I; INMED, INSERM, Unité 901, Marseille, France.; Aix-Marseille Université, UMR 901, Marseille, France., Brandon NJ; AstraZeneca Tufts Laboratory for Basic and Translational Neuroscience, Boston, Massachusetts, USA.; Neuroscience, IMED Biotech Unit, AstraZeneca, Boston, Massachusetts, USA., Deeb TZ; AstraZeneca Tufts Laboratory for Basic and Translational Neuroscience, Boston, Massachusetts, USA., Moss SJ; AstraZeneca Tufts Laboratory for Basic and Translational Neuroscience, Boston, Massachusetts, USA.; Department of Neuroscience, Tufts University School of Medicine, Boston, Massachusetts, USA.; Department of Neuroscience, Physiology and Pharmacology, University College London, London, UK.

Publikováno v: Nature medicine [Nat Med] 2017 Dec 07; Vol. 23 (12), pp. 1394-1396.

Investigation of connexin 43 uncoupling and prolongation of the cardiac QRS complex in preclinical and marketed drugs.

Autor: Burnham MP; Safety Assessment, AstraZeneca R&D, Macclesfield, UK; Discovery Sciences, AstraZeneca R&D, Macclesfield, UK., Sharpe PM, Garner C, Hughes R, Pollard CE, Bowes J

Publikováno v: British journal of pharmacology [Br J Pharmacol] 2014 Nov; Vol. 171 (21), pp. 4808-19. Date of Electronic Publication: 2014 Aug 13.

Inhibition of TGF-beta 3 (but not TGF-beta 1 or TGF-beta 2) activity prevents normal mouse embryonic palate fusion.

Autor: Brunet CL; Division of Cells, Immunology and Development, School of Biological Sciences, University of Manchester, United Kingdom., Sharpe PM, Ferguson MW

Publikováno v: The International journal of developmental biology [Int J Dev Biol] 1995 Apr; Vol. 39 (2), pp. 345-55.

Localisation of acidic and basic fibroblast growth factors during mouse palate development and their effects on mouse palate mesenchyme cells in vitro.

Autor: Sharpe PM; Animal and Human Reproduction, Development and Growth Research Group, Department of Cell and Structural Biology, University of Manchester, Stopford Building, Oxford Road, M13 9PT, Manchester, England., Brunet CL; Animal and Human Reproduction, Development and Growth Research Group, Department of Cell and Structural Biology, University of Manchester, Stopford Building, Oxford Road, M13 9PT, Manchester, England., Foreman DM; Animal and Human Reproduction, Development and Growth Research Group, Department of Cell and Structural Biology, University of Manchester, Stopford Building, Oxford Road, M13 9PT, Manchester, England., Ferguson MW; Animal and Human Reproduction, Development and Growth Research Group, Department of Cell and Structural Biology, University of Manchester, Stopford Building, Oxford Road, M13 9PT, Manchester, England.

Publikováno v: Roux's archives of developmental biology : the official organ of the EDBO [Rouxs Arch Dev Biol] 1993 Feb; Vol. 202 (3), pp. 132-143.

Modulation of the epidermal growth factor receptor of mouse embryonic palatal mesenchyme cells in vitro by growth factors.

Autor: Sharpe PM; Department of Cell and Structural Biology, University of Manchester, United Kingdom., Brunet CL, Ferguson MW

Publikováno v: The International journal of developmental biology [Int J Dev Biol] 1992 Jun; Vol. 36 (2), pp. 275-82.