Výsledky vyhledávání - "Sharpe, David T"

Akademický článek

Androgens trigger different growth responses in genetically identical human hair follicles in organ culture that reflect their epigenetic diversity in life

Autor: Miranda, Benjamin H., Charlesworth, Matthew R., Tobin, Desmond J., Sharpe, David T., Randall, Valerie A.

Yes
Male sex hormones-androgens-regulate male physique development. Without androgen signaling, genetic males appear female. During puberty, increasing androgens harness the hair follicle's unique regenerative ability to replace many tiny vellus

Externí odkaz: http://hdl.handle.net/10454/14146

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Akademický článek

Inhibition of bone morphogenetic protein signalling promotes wound healing in a human ex vivo model

Autor: Lewis, Christopher J., Mardaryev, Andrei N., Sharpe, David T., Botchkareva, Natalia V.

Bone morphogenetic proteins (BMPs) and their receptors (BMPRs) play roles in embryonic development and postnatal remodelling of the skin. Many indications suggest that BMP signalling regulates keratinocyte proliferation and differentiation. Chronic w

Externí odkaz: http://hdl.handle.net/10454/9371

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Akademický článek

Bone morphogenetic protein signaling suppresses wound-induced skin repair by inhibiting keratinocyte proliferation and migration

Autor: Lewis, Christopher J., Mardaryev, Andrei N., Poterlowicz, Krzysztof, Sharova, T.Y., Aziz, A., Sharpe, David T., Botchkareva, Natalia V., Sharov, A.A.

Bone morphogenetic protein (BMP) signaling plays a key role in the control of skin development and postnatal remodeling by regulating keratinocyte proliferation, differentiation, and apoptosis. To study the role of BMPs in wound-induced epidermal rep

Externí odkaz: http://hdl.handle.net/10454/6067

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Akademický článek

Intermediate hair follicles: a new more clinically relevant model for hair growth investigations

Autor: Miranda, Benjamin H., Tobin, Desmond J., Sharpe, David T., Randall, Valerie A.

BACKGROUND: Alopecia causes widespread psychological distress, but is relatively poorly controlled. The development of new treatments is hampered by the lack of suitable human hair follicle models. Although intermediate and vellus hair follicles are

Externí odkaz: http://hdl.handle.net/10454/6098

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