Changes in iPSC-Astrocyte morphology reflect Alzheimer's disease patient clinical markers.

Autor: Rowland HA; Department of Psychiatry, University of Oxford, Headington, Oxford OX3 7JX, UK.; Kavli Institute for Nanoscience Discovery, University of Oxford, Dorothy Crowfoot Hodgkin Building, South Parks Road, Oxford OX1 3QU, UK., Miller G; Department of Psychiatry, University of Oxford, Headington, Oxford OX3 7JX, UK.; Kavli Institute for Nanoscience Discovery, University of Oxford, Dorothy Crowfoot Hodgkin Building, South Parks Road, Oxford OX1 3QU, UK., Liu Q; Department of Psychiatry, University of Oxford, Headington, Oxford OX3 7JX, UK.; Oxford Precision Psychiatry Lab, NIHR Oxford Health Biomedical Research Centre, Oxford OX3 7JX, UK.; School of Engineering Mathematics and Technology, University of Bristol, Bristol BS8 1TW, UK., Li S; Department of Psychiatry, University of Oxford, Headington, Oxford OX3 7JX, UK.; Kavli Institute for Nanoscience Discovery, University of Oxford, Dorothy Crowfoot Hodgkin Building, South Parks Road, Oxford OX1 3QU, UK., Sharp NR; Department of Psychiatry, University of Oxford, Headington, Oxford OX3 7JX, UK.; Kavli Institute for Nanoscience Discovery, University of Oxford, Dorothy Crowfoot Hodgkin Building, South Parks Road, Oxford OX1 3QU, UK., Ng B; Kavli Institute for Nanoscience Discovery, University of Oxford, Dorothy Crowfoot Hodgkin Building, South Parks Road, Oxford OX1 3QU, UK.; Department of Physiology Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QU, UK.; Singapore Institute for Clinical Sciences (SICS), Agency for Science, Technology and Research (A*STAR), 30 Medical Drive, Singapore 117609, Republic of Singapore., Wei T; Kavli Institute for Nanoscience Discovery, University of Oxford, Dorothy Crowfoot Hodgkin Building, South Parks Road, Oxford OX1 3QU, UK.; Nuffield Department of Clinical Neurosciences, University of Oxford, Dorothy Crowfoot Hodgkin Building, South Parks Road, Oxford OX1 3QU, UK., Arunasalam K; Nuffield Department of Clinical Neurosciences, University of Oxford, Dorothy Crowfoot Hodgkin Building, South Parks Road, Oxford OX1 3QU, UK., Koychev I; Department of Psychiatry, University of Oxford, Headington, Oxford OX3 7JX, UK., Hedegaard A; Department of Psychiatry, University of Oxford, Headington, Oxford OX3 7JX, UK.; Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK., Ribe EM; Department of Psychiatry, University of Oxford, Headington, Oxford OX3 7JX, UK.; Department of Old Age Psychiatry, Maurice Wohl Institute of Clinical Neurosciences, SE5 9RT, King's College London, London., Chan D; Department of Clinical Neurosciences, University of Cambridge, Cambridge CB2 0QQ, UK.; Institute of Cognitive Neuroscience, University College London WC1N 3AR, UK., Chessell T; Neuroscience, Bio*P*harmaceuticals R&D, AstraZeneca, Granta Park, Cambridge, CB21 6GH, UK., Kocagoncu E; Medical Research Council Cognition and Brain Sciences Unit, Department of Clinical Neurosciences and Cambridge University Hospitals NHS Trust, University of Cambridge, Cambridge CB2 7EF, UK., Lawson J; Department of Psychiatry, University of Oxford, Headington, Oxford OX3 7JX, UK., Malhotra P; Department of Brain Sciences, Imperial College London, Charing Cross Campus, London W6 8RP, UK., Ridha BH; Dementia Research Centre, UCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK., Rowe JB; Medical Research Council Cognition and Brain Sciences Unit, Department of Clinical Neurosciences and Cambridge University Hospitals NHS Trust, University of Cambridge, Cambridge CB2 7EF, UK., Thomas AJ; Translational and Clinical Research Institute, Newcastle University, Newcastle, UK., Zamboni G; Nuffield Department of Clinical Neurosciences, Headington, University of Oxford, Oxford OX3 9DS, UK.; Department of Biomedical, Metabolic, and Neural Science, University of Modena and Reggio Emilia, Ospedale Civile Baggiovara, 41126 Modena, Italy., Zetterberg H; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, S-431 80 Mölndal, Sweden.; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, S-431 80 Mölndal, Sweden.; Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London, WC1N 6BG, UK.; UK Dementia Research Institute at UCL, London, WC1N 6BG, UK.; Hong Kong Center for Neurodegenerative Diseases, Clear Water Bay, Hong Kong, China.; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53792, USA., Cader MZ; Kavli Institute for Nanoscience Discovery, University of Oxford, Dorothy Crowfoot Hodgkin Building, South Parks Road, Oxford OX1 3QU, UK.; Nuffield Department of Clinical Neurosciences, University of Oxford, Dorothy Crowfoot Hodgkin Building, South Parks Road, Oxford OX1 3QU, UK., Wade-Martins R; Kavli Institute for Nanoscience Discovery, University of Oxford, Dorothy Crowfoot Hodgkin Building, South Parks Road, Oxford OX1 3QU, UK.; Department of Physiology Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QU, UK., Lovestone S; Department of Psychiatry, University of Oxford, Headington, Oxford OX3 7JX, UK.; Currently at Janssen Medical UK, 50-100 Holmers Farm Way, High Wycombe HP12 4EG, UK., Nevado-Holgado A; Department of Psychiatry, University of Oxford, Headington, Oxford OX3 7JX, UK., Kormilitzin A; Department of Psychiatry, University of Oxford, Headington, Oxford OX3 7JX, UK., Buckley NJ; Department of Psychiatry, University of Oxford, Headington, Oxford OX3 7JX, UK.; Kavli Institute for Nanoscience Discovery, University of Oxford, Dorothy Crowfoot Hodgkin Building, South Parks Road, Oxford OX1 3QU, UK.

Publikováno v: Stem cells (Dayton, Ohio) [Stem Cells] 2024 Dec 20. Date of Electronic Publication: 2024 Dec 20.