Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Sharon Yeoh"'
Publikováno v:
Molecular Oncology, Vol 17, Iss 11, Pp 2218-2220 (2023)
Immune checkpoint inhibitors (ICIs) are utilised in treating non‐small cell lung cancer (NSCLC) by enhancing the immune response against cancer cells. However, they are not effective against cancers with certain genetic alterations. A recent study
Externí odkaz:
https://doaj.org/article/390dd4161ff04e17b77dc585116d9656
Autor:
Philippa K Harris, Sharon Yeoh, Anton R Dluzewski, Rebecca A O'Donnell, Chrislaine Withers-Martinez, Fiona Hackett, Lawrence H Bannister, Graham H Mitchell, Michael J Blackman
Publikováno v:
PLoS Pathogens, Vol 1, Iss 3, Pp 241-251 (2005)
Proteolytic shedding of surface proteins during invasion by apicomplexan parasites is a widespread phenomenon, thought to represent a mechanism by which the parasites disengage adhesin-receptor complexes in order to gain entry into their host cell. E
Externí odkaz:
https://doaj.org/article/1183b80983454879893ee7bcda843f01
Publikováno v:
Open Biology, Vol 2, Iss 11 (2012)
During mitosis, human cells exhibit a peak of protein phosphorylation that alters the behaviour of a significant proportion of proteins, driving a dramatic transformation in the cell's shape, intracellular structures and biochemistry. These mitotic p
Externí odkaz:
https://doaj.org/article/64a13de17cc4463990ff91d466f07616
Autor:
Chitra Bhatia, Katherine H. Carr, Sharon Yeoh, Corine Mas-Droux, Richard Bayliss, Rory F. Cunnison, Matthew J. Byrne, Nazia Nasir, Celine Cano, Christine Basmadjian
Publikováno v:
'Biochemical Journal ', vol: 477, pages: 1525-1539 (2020)
Biochemical Journal
Biochemical Journal
Nek7 is a serine/threonine-protein kinase required for proper spindle formation and cytokinesis. Elevated Nek7 levels have been observed in several cancers, and inhibition of Nek7 might provide a route to the development of cancer therapeutics. To da
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83d9a93b8caa7633c58a85a48c53e0fc
https://doi.org/10.1042/bcj20200128
https://doi.org/10.1042/bcj20200128
Publikováno v:
Journal of Biological Chemistry. 298:102247
Protein kinases are key components in cellular signaling pathways as they carry out the phosphorylation of proteins, primarily on Ser, Thr, and Tyr residues. The catalytic activity of protein kinases is regulated, and they can be thought of as molecu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1144f1600c3e02fa2e34ca713637f218
https://doi.org/10.1016/j.jbc.2022.102247
https://doi.org/10.1016/j.jbc.2022.102247
Autor:
Sharon Yeoh, Richard Bayliss
Publikováno v:
Biochemical Journal
Sulfation is a common modification of extracelluar glycans and tyrosine residues on proteins, which is important in many signalling pathways and interactions. Existing methods for studying sulfotransferases, the enzymes that catalyse sulfation, are c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::829e9dfe73fbed575da9040752265ec5
http://europepmc.org/articles/PMC6173261
http://europepmc.org/articles/PMC6173261
Publikováno v:
Molecular biology reports. 47(4)
Zika virus is a mosquito-borneFlavivirusoriginally isolated from humans in 1952. Following its re-emergence in Brazil in 2015, an increase in the number of babies born with microcephaly to infected mothers was observed. Microcephaly is a neurodevelop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9bf4c8fe976afdba83811d49991246c
https://pubmed.ncbi.nlm.nih.gov/32128708
https://pubmed.ncbi.nlm.nih.gov/32128708
Autor:
Anthony A. Holder, Sharon Yeoh, Ellen Knuepfer, Avshalom J. Atid, Christine R. Collins, Michael J. Blackman, Fiona Hackett, Chrislaine Withers-Martinez, Robert Stallmach, Manoli Kavishwar, Steven Howell
Publikováno v:
Molecular Microbiology
The malaria parasite Plasmodium falciparum replicates in an intraerythrocytic parasitophorous vacuole (PV). The most abundant P. falciparum PV protein, called SERA5, is essential in blood stages and possesses a papain-like domain, prompting speculati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33ff38da8559e221e6d95e6450f8af24
https://doi.org/10.1111/mmi.12941
https://doi.org/10.1111/mmi.12941
Autor:
Chrislaine Withers-Martinez, Sharon Yeoh, Michael J. Blackman, Matthew A. Child, Christine R. Collins, Philippa K Harris
Publikováno v:
Traffic. 14:1053-1064
The malaria merozoite invades erythrocytes in the vertebrate host. Iterative rounds of asexual intraerythrocytic replication result in disease. Proteases play pivotal roles in erythrocyte invasion, but little is understood about their mode of action.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::78b64b26d1d53b5a2e59dde619528f9e
https://doi.org/10.1111/tra.12092
https://doi.org/10.1111/tra.12092
Autor:
Kwai-Ming J. Cheung, Joanne E. Baxter, Andrew M. Fry, K. Boxall, Savade Solanki, Swen Hoelder, Tara Hardy, Paolo Innocenti, Lisa Pickard, Fiona C. Rowan, Corine Mas-Droux, G.W. Aherne, Maura Westlake, Richard Bayliss, Sharon Yeoh
Publikováno v:
Journal of Medicinal Chemistry. 55:3228-3241
We report herein a series of Nek2 inhibitors based on an aminopyridine scaffold. These compounds have been designed by combining key elements of two previously discovered chemical series. Structure based design led to aminopyridine (R)-21, a potent a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ca4fb1393808f0e7b8cbff3fe2a1136
https://doi.org/10.1021/jm201683b
https://doi.org/10.1021/jm201683b