Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Sharon Y. R. Dent"'
Autor:
Xianghong Kuang, Andrew Salinger, Fernando Benavides, William J. Muller, Sharon Y. R. Dent, Evangelia Koutelou
Publikováno v:
PLoS ONE, Vol 19, Iss 1 (2024)
Externí odkaz:
https://doaj.org/article/0a9b6f6df1354369bd12791254dcb361
Autor:
Ying-Jiun C. Chen, Sharon Y. R. Dent
Publikováno v:
Epigenetics & Chromatin, Vol 14, Iss 1, Pp 1-11 (2021)
Abstract The SAGA complex is an evolutionarily conserved transcriptional coactivator that regulates gene expression through its histone acetyltransferase and deubiquitylase activities, recognition of specific histone modifications, and interactions w
Externí odkaz:
https://doaj.org/article/ff61c8572e3448ed812620572013265a
Autor:
Yuanxin Xi, Jiejun Shi, Wenqian Li, Kaori Tanaka, Kendra L. Allton, Dana Richardson, Jing Li, Hector L. Franco, Anusha Nagari, Venkat S. Malladi, Luis Della Coletta, Melissa S. Simper, Khandan Keyomarsi, Jianjun Shen, Mark T. Bedford, Xiaobing Shi, Michelle C. Barton, W. Lee Kraus, Wei Li, Sharon Y. R. Dent
Publikováno v:
BMC Genomics, Vol 19, Iss 1, Pp 1-11 (2018)
Abstract Background Epigenetic regulators are frequently mutated or aberrantly expressed in a variety of cancers, leading to altered transcription states that result in changes in cell identity, behavior, and response to therapy. Results To define al
Externí odkaz:
https://doaj.org/article/b6b28abd82404ab384f6ee9983f4d6f1
Autor:
Wenyi Mi, Haipeng Guan, Jie Lyu, Dan Zhao, Yuanxin Xi, Shiming Jiang, Forest H. Andrews, Xiaolu Wang, Mihai Gagea, Hong Wen, Laszlo Tora, Sharon Y. R. Dent, Tatiana G. Kutateladze, Wei Li, Haitao Li, Xiaobing Shi
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Histone modification recognition is an important mechanism for gene expression regulation in cancer. Here, the authors identify YEATS2 as a histone H3K27ac reader, regulating a transcriptional program essential for tumorigenesis in human non-small ce
Externí odkaz:
https://doaj.org/article/be7fccc0c928460dac1868ae040b124c
Autor:
Sharon Y. R. Dent
Publikováno v:
Frontiers in Epigenetics and Epigenomics. 1
Our understanding of the regulation and functions of histone modifications has come a long way since they were first reported in the mid-1960s. So too has our understanding of the importance of DNA methylation, histone variants, nucleosome locations
Autor:
Xianghong Kuang, Andrew Salinger, Fernando Benavides, William J. Muller, Sharon Y. R. Dent, Evangelia Koutelou
The USP22 deubiquitinase, a component of the SAGA histone modifying complex, is overexpressed in multiple human cancers, but how USP22 impacts tumorigenesis is not clear. We reported previously that Usp22 loss in mice impacts execution of several sig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8727ed4da9f1b204c01779333df83072
https://doi.org/10.1101/2022.09.28.510017
https://doi.org/10.1101/2022.09.28.510017
Autor:
Evangelia Koutelou, Sharon Y. R. Dent
Publikováno v:
Nature Cell Biology. 24:412-414
Autor:
Qihuang, Jin, Li-Rong, Yu, Lifeng, Wang, Zhijing, Zhang, Lawryn H, Kasper, Ji-Eun, Lee, Chaochen, Wang, Paul K, Brindle, Sharon Y R, Dent, Kai, Ge
Publikováno v:
The EMBO journal. 30(2)
Histone acetyltransferases (HATs) GCN5 and PCAF (GCN5/PCAF) and CBP and p300 (CBP/p300) are transcription co-activators. However, how these two distinct families of HATs regulate gene activation remains unclear. Here, we show deletion of GCN5/PCAF in
Publikováno v:
Development, growthdifferentiation. 50(5)
Histone acetylation plays important roles in gene regulation. However, the functions of individual histone acetyltransferases (HATs) in specific developmental transcription programs are not well defined. To define the functions of Gcn5, a prototypica
Autor:
Tania M, Malavé, Sharon Y R, Dent
Publikováno v:
Biochemistry and cell biology = Biochimie et biologie cellulaire. 84(4)
The Tup1-Ssn6 complex from budding yeast is one of the best studied corepressors and has served as a model for the study of similar corepressor complexes in higher eukaryotes. Tup1-Ssn6 represses multiple subsets of genes when recruited to promoters