Výsledky vyhledávání - "Sharon Vinsant"

Characterization of early pathogenesis in the SOD1G93Amouse model of ALS: part II, results and discussion

Autor: Sharon Vinsant, Ramón Jiménez-Moreno, Carol Milligan, James B. Caress, Victoria Del Gaizo Moore, Carol Mansfield, Ronald W. Oppenheim, Thomas G. Hampton, Masaaki Yoshikawa, David Prevette

Publikováno v: Brain and Behavior

Pathological events are well characterized in amyotrophic lateral sclerosis (ALS) mouse models, but review of the literature fails to identify a specific initiating event that precipitates disease pathology. There is now growing consensus in the fiel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c734c66beaaade1144b3bace02ba20e
https://doi.org/10.1002/brb3.142

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Misplacement of Purkinje Cells during Postnatal Development in Bax Knock-Out Mice: A Novel Role for Programmed Cell Death in the Nervous System?

Autor: Im Joo Rhyu, Tae Woo Kim, Woong Sun, A-rong Jung, Ronald W. Oppenheim, Young-Don Lee, Sharon Vinsant, Hyun Kim

Publikováno v: The Journal of Neuroscience. 28:2941-2948

During early postnatal development, the orchestrated regulation of proliferation, migration and the survival versus elimination of neurons is essential for histogenesis of the cerebellum. For instance, Purkinje cells (PCs) promote the proliferation a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36c0c25ddda9e6c64961705dcfcbe7d0
https://doi.org/10.1523/jneurosci.3897-07.2008

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Developing Postmitotic Mammalian NeuronsIn VivoLacking Apaf-1 Undergo Programmed Cell Death by a Caspase-Independent, Nonapoptotic Pathway Involving Autophagy

Autor: Kevin A. Roth, Changlian Zhu, Sharon Vinsant, David Prevette, Klas Blomgren, Ronald W. Oppenheim, Douglas W. Ethell, Yasuo Uchiyama, Masato Koike, Masaaki Komatsu

Publikováno v: The Journal of Neuroscience. 28:1490-1497

Previous studies have shown that caspases and Apaf-1 are required for the normal programmed cell death (PCD)in vivoof immature postmitotic neurons and mitotically active neuronal precursor cells. In contrast, caspase activity is not necessary for the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9d77d4bd72165c6a4e4ac0126e59964
https://doi.org/10.1523/jneurosci.4575-07.2008

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Impaired Migration in the Rostral Migratory Stream But Spared Olfactory Function after the Elimination of Programmed Cell Death in Bax Knock-Out Mice

Autor: Sharon Vinsant, Woon Ryoung Kim, Ronald W. Oppenheim, Younghwa Kim, Chang-Hwan Park, Woong Sun, Kyungjin Kim, Hyun Kim, Ok-hee Park, Bokkee Eun

Publikováno v: The Journal of Neuroscience. 27:14392-14403

Rats and mice exhibit neurogenesis of olfactory bulb (OB) interneurons throughout adulthood. To homeostatically maintain stable neuron numbers, it is necessary to continuously remove a subset of OB neurons by programmed cell death (PCD). Here we demo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9e5495627fe109915bcc98197860d4a
https://doi.org/10.1523/jneurosci.3903-07.2007

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Neuromuscular Development in the Absence of Programmed Cell Death: Phenotypic Alteration of Motoneurons and Muscle

Autor: Ronald W. Oppenheim, David Prevette, Adam K. Winseck, Robert R. Buss, Jianjun Ma, Kimberly A. Toops, Thomas L. Smith, Thomas W. Gould, Sharon Vinsant, James A Hammarback

Publikováno v: The Journal of Neuroscience. 26:13413-13427

The widespread, massive loss of developing neurons in the central and peripheral nervous system of birds and mammals is generally considered to be an evolutionary adaptation. However, until recently, models for testing both the immediate and long-ter

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::934b79b98c556ba89ba65f8948b52b5a
https://doi.org/10.1523/jneurosci.3528-06.2006

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Programmed Cell Death of Adult-Generated Hippocampal Neurons Is Mediated by the Proapoptotic Gene Bax

Autor: Woong Sun, Ronald W. Oppenheim, Hyun Kim, Ok Hee Park, Adam K. Winseck, Sharon Vinsant

Publikováno v: The Journal of Neuroscience. 24:11205-11213

In the dentate gyrus (DG) of the adult mouse hippocampus, a substantial number of new cells are generated daily, but only a subset of these survive and differentiate into mature neurons, whereas the majority undergo programmed cell death (PCD). Howev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ea9cf2eb6c7ffa030543ac71bbffcfb
https://doi.org/10.1523/jneurosci.1436-04.2004

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Neuromuscular Development after the Prevention of Naturally Occurring Neuronal Death by Bax Deletion

Autor: David Prevette, Ronald W. Oppenheim, Woong Sun, Thomas W. Gould, Sharon Vinsant

Publikováno v: The Journal of Neuroscience. 23:7298-7310

The removal of excess neurons by programmed cell death (PCD) is believed to be critical for the proper development and function of the nervous system. A major role of this neuronal loss is to attain quantitative matching of neurons with their targets

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96d1aacb5d9e0907e4975a74ee621db5
https://doi.org/10.1523/jneurosci.23-19-07298.2003

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Differential expression of the GDNF family receptors RET and GFR?1, 2, and 4 in subsets of motoneurons: A relationship between motoneuron birthdate and receptor expression

Autor: Megumi Kawata, Miho Seino, Nobumi Kobayashi, Hiroyuki Yaginuma, Thomas J. Gould, Sharon Vinsant, Takako Shimada, Ronald W. Oppenheim, Shunsaku Homma

Publikováno v: The Journal of Comparative Neurology. 456:245-259

Previous studies have demonstrated the expression of specific members of the glial cell line-derived neurotrophic factor (GDNF) receptor family alpha (GFRalpha) in subsets of motoneurons (MNs) in the developing mouse spinal cord. We examined the expr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::394c62f771edd377ba7dfd79e9225e58
https://doi.org/10.1002/cne.10529

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Programmed Cell Death of Developing Mammalian Neurons after Genetic Deletion of Caspases

Autor: Richard A. Flavell, Sharon Vinsant, Pasko Rakic, Ronald W. Oppenheim, Chia-Y. Kuan, David Prevette

Publikováno v: The Journal of Neuroscience. 21:4752-4760

An analysis of programmed cell death of several populations of developing postmitotic neurons after genetic deletion of two key members of the caspase family of pro-apoptotic proteases, caspase-3 and caspase-9, indicates that normal neuronal loss occ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27d8b59ab34db1673c68b1450ba3fd6d
https://doi.org/10.1523/jneurosci.21-13-04752.2001

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Effect of cocaine self-administration on dopamine D2 receptors in rhesus monkeys

Autor: Rodney J. Moore, Linda J. Porrino, Michael A. Nader, David Friedman, Sharon Vinsant

Publikováno v: Synapse. 30:88-96

The present study used autoradiography to examine the effects of chronic self-administration of cocaine on the density of dopamine D2 receptors in nonhuman primates. Three rhesus monkeys intravenously self-administered an average of 1.35 mg/kg cocain

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bfb1c7b51b5f08e19b9d0594a154fccc
https://doi.org/10.1002/(sici)1098-2396(199809)30:1<88::aid-syn11>3.0.co

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