Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Sharon Vinsant"'
Autor:
Sharon Vinsant, Ramón Jiménez-Moreno, Carol Milligan, James B. Caress, Victoria Del Gaizo Moore, Carol Mansfield, Ronald W. Oppenheim, Thomas G. Hampton, Masaaki Yoshikawa, David Prevette
Publikováno v:
Brain and Behavior
Pathological events are well characterized in amyotrophic lateral sclerosis (ALS) mouse models, but review of the literature fails to identify a specific initiating event that precipitates disease pathology. There is now growing consensus in the fiel
Autor:
Im Joo Rhyu, Tae Woo Kim, Woong Sun, A-rong Jung, Ronald W. Oppenheim, Young-Don Lee, Sharon Vinsant, Hyun Kim
Publikováno v:
The Journal of Neuroscience. 28:2941-2948
During early postnatal development, the orchestrated regulation of proliferation, migration and the survival versus elimination of neurons is essential for histogenesis of the cerebellum. For instance, Purkinje cells (PCs) promote the proliferation a
Autor:
Kevin A. Roth, Changlian Zhu, Sharon Vinsant, David Prevette, Klas Blomgren, Ronald W. Oppenheim, Douglas W. Ethell, Yasuo Uchiyama, Masato Koike, Masaaki Komatsu
Publikováno v:
The Journal of Neuroscience. 28:1490-1497
Previous studies have shown that caspases and Apaf-1 are required for the normal programmed cell death (PCD)in vivoof immature postmitotic neurons and mitotically active neuronal precursor cells. In contrast, caspase activity is not necessary for the
Autor:
Sharon Vinsant, Woon Ryoung Kim, Ronald W. Oppenheim, Younghwa Kim, Chang-Hwan Park, Woong Sun, Kyungjin Kim, Hyun Kim, Ok-hee Park, Bokkee Eun
Publikováno v:
The Journal of Neuroscience. 27:14392-14403
Rats and mice exhibit neurogenesis of olfactory bulb (OB) interneurons throughout adulthood. To homeostatically maintain stable neuron numbers, it is necessary to continuously remove a subset of OB neurons by programmed cell death (PCD). Here we demo
Autor:
Ronald W. Oppenheim, David Prevette, Adam K. Winseck, Robert R. Buss, Jianjun Ma, Kimberly A. Toops, Thomas L. Smith, Thomas W. Gould, Sharon Vinsant, James A Hammarback
Publikováno v:
The Journal of Neuroscience. 26:13413-13427
The widespread, massive loss of developing neurons in the central and peripheral nervous system of birds and mammals is generally considered to be an evolutionary adaptation. However, until recently, models for testing both the immediate and long-ter
Publikováno v:
The Journal of Neuroscience. 24:11205-11213
In the dentate gyrus (DG) of the adult mouse hippocampus, a substantial number of new cells are generated daily, but only a subset of these survive and differentiate into mature neurons, whereas the majority undergo programmed cell death (PCD). Howev
Neuromuscular Development after the Prevention of Naturally Occurring Neuronal Death by Bax Deletion
Publikováno v:
The Journal of Neuroscience. 23:7298-7310
The removal of excess neurons by programmed cell death (PCD) is believed to be critical for the proper development and function of the nervous system. A major role of this neuronal loss is to attain quantitative matching of neurons with their targets
Autor:
Megumi Kawata, Miho Seino, Nobumi Kobayashi, Hiroyuki Yaginuma, Thomas J. Gould, Sharon Vinsant, Takako Shimada, Ronald W. Oppenheim, Shunsaku Homma
Publikováno v:
The Journal of Comparative Neurology. 456:245-259
Previous studies have demonstrated the expression of specific members of the glial cell line-derived neurotrophic factor (GDNF) receptor family alpha (GFRalpha) in subsets of motoneurons (MNs) in the developing mouse spinal cord. We examined the expr
Autor:
Richard A. Flavell, Sharon Vinsant, Pasko Rakic, Ronald W. Oppenheim, Chia-Y. Kuan, David Prevette
Publikováno v:
The Journal of Neuroscience. 21:4752-4760
An analysis of programmed cell death of several populations of developing postmitotic neurons after genetic deletion of two key members of the caspase family of pro-apoptotic proteases, caspase-3 and caspase-9, indicates that normal neuronal loss occ
Publikováno v:
Synapse. 30:88-96
The present study used autoradiography to examine the effects of chronic self-administration of cocaine on the density of dopamine D2 receptors in nonhuman primates. Three rhesus monkeys intravenously self-administered an average of 1.35 mg/kg cocain