Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Sharon T. Cload"'
Autor:
Anthony D. Keefe, Sharon T. Cload
Publikováno v:
Current Opinion in Chemical Biology. 12:448-456
Aptamers, a promising new class of therapeutics, are single-stranded oligonucleotides generated via an in vitro selection process that bind to and inhibit the activity of target proteins in a manner similar to therapeutic antibodies. In order to enha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3797a35f846c249e69e78707bfbe5116
https://doi.org/10.1016/j.cbpa.2008.06.028
https://doi.org/10.1016/j.cbpa.2008.06.028
Autor:
Jeffrey Kurz, Sara Chesworth Keene, John L. Diener, Ryan M. Boomer, Jayaram Srinivasan, Charles Wilson, David Epstein, Markus Kurz, Jill Blanchard, Nobuko Hamaguchi, Sharon T. Cload
Publikováno v:
Chemistry & Biology. 11(4):499-508
Two molecular sensors that specifically recognize ADP in a background of over 100-fold molar excess of ATP are described. These sensors are nucleic-acid based and comprise a general method for monitoring protein kinase activity. The ADP-aptamer scint
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e6b17205ce2856e3f472a40b63c0777
Autor:
John L. Diener, Sharon T. Cload, Markus Kurz, Anthony D. Keefe, Sara Chesworth Keene, Ryan M. Boomer, Charles Wilson, Alicia Ferguson
Publikováno v:
Nucleic Acids Research. 32:1756-1766
We have utilized in vitro selection technology to develop allosteric ribozyme sensors that are specific for the small molecule analytes caffeine or aspartame. Caffeine- or aspartame-responsive ribozymes were converted into fluorescence-based RiboRepo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc38a281fded66c3f53f155a83d914c5
https://doi.org/10.1093/nar/gkh336
https://doi.org/10.1093/nar/gkh336
Autor:
Alanna Schepartz, Sharon T. Cload
Publikováno v:
Journal of the American Chemical Society. 116:437-442
We devised a single-step selection method to identify short sequences within the folded Rev response element (RRE) of the human immunodeficiency virus (HIV) RNA genome that are proximal and able to bind short oligonucleotides. The method employed a l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::58a55857da4ebf26c9117a7ac13e6ca6
https://doi.org/10.1021/ja00081a002
https://doi.org/10.1021/ja00081a002
Publikováno v:
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 34(1)
Small molecule drugs are relatively effective in working on 'drugable' targets such as GPCRs, ion channels, kinases, proteases, etc but ineffective at blocking protein-protein interactions that represent an emerging class of 'nondrugable' central ner
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ddeaa82fa45ce7939527bd67a0c9d1b
https://pubmed.ncbi.nlm.nih.gov/18754007
https://pubmed.ncbi.nlm.nih.gov/18754007
Publikováno v:
ChemInform. 39
Aptamers are non-naturally occurring structured oligonucleotides that may bind to small molecules, peptides, and proteins. Typically, aptamers are generated by an in vitro selection process referred to as SELEX (systematic evolution of ligands by exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f038001516590495ebc34c7da3369514
https://doi.org/10.1002/chin.200818243
https://doi.org/10.1002/chin.200818243
Publikováno v:
Accounts of chemical research. 41(1)
Aptamers are non-naturally occurring structured oligonucleotides that may bind to small molecules, peptides, and proteins. Typically, aptamers are generated by an in vitro selection process referred to as SELEX (systematic evolution of ligands by exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e293282f1d4cd347ff62372dd33fe46b
https://pubmed.ncbi.nlm.nih.gov/18193823
https://pubmed.ncbi.nlm.nih.gov/18193823
Autor:
Paula Burmeister, Charles Wilson, Chunhua Wang, Scott D. Lewis, Thomas Green Mccauley, Markus Kurz, Anthony D. Keefe, P. Shannon Pendergrast, Jason R. Killough, Alicia Ferguson, Sharon T. Cload, Lillian R. Horwitz, Kristin Thompson, John L. Diener
Publikováno v:
Oligonucleotides. 16(4)
Aptamers are short oligonucleotides that fold into well-defined three-dimensional architectures thereby enabling specific binding to molecular targets such as proteins. To be successful as a novel therapeutic modality, it is important for aptamers to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eca5773d3338e044b4b15cea62d63d7d
https://pubmed.ncbi.nlm.nih.gov/17155909
https://pubmed.ncbi.nlm.nih.gov/17155909
Publikováno v:
The Aptamer Handbook: Functional Oligonucleotides and Their Applications
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e23e7c0974876e18807e9d327563a51c
https://doi.org/10.1002/3527608192.ch17
https://doi.org/10.1002/3527608192.ch17
