Výsledky vyhledávání - "Sharon Safrin"

High-Resolution Computed Tomography in Idiopathic Pulmonary Fibrosis

Autor: Sharon Safrin, Ganesh Raghu, J. David Godwin, David A. Lynch, Karen M. Starko, Williamson Z. Bradford, Talmadge E. King, Phil Hormel, W. Richard Webb, Kevin K. Brown, David A. Schwartz

Publikováno v: American Journal of Respiratory and Critical Care Medicine. 172:488-493

High-resolution computed tomography (HRCT) is an integral aspect of the evaluation of patients with suspected idiopathic pulmonary fibrosis (IPF). However, few studies have evaluated its use in a large cohort.To describe HRCT features in patients wit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02dfcb9520abdcf91934a925abd3845b
https://doi.org/10.1164/rccm.200412-1756oc

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Analyses of Efficacy End Points in a Controlled Trial of Interferon-γ1b for Idiopathic Pulmonary Fibrosis

Autor: Paul W. Noble, Karen M. Starko, Ganesh Raghu, Kevin K. Brown, Talmadge E. King, Sharon Safrin, David A. Schwartz

Publikováno v: Chest. 127:171-177

Background Idiopathic pulmonary fibrosis (IPF) is a devastating disease, yet validated, reliable criteria for evaluating patient response to therapies in clinical trials are lacking. Methods To optimize selection of end point criteria for the study o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddf7fbfe95a6091043138a53972add6c
https://doi.org/10.1378/chest.127.1.171

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Pharmacokinetics in Animals and Humans of a First-in-Class Peptide Deformylase Inhibitor

Autor: Sue Barrowcliffe, Clive Moore, Juliet McColm, Kirk W. Johnson, Sandhya Ramanathan-Girish, Gary Patou, Vernon Jiang, Phil Taupin, Heinz E. Moser, Denene Lofland, Ute Hoch, John M. Clements, Alison Gadd, Sharon Safrin, John Hevizi

Publikováno v: Antimicrobial Agents and Chemotherapy. 48:4835-4842

BB-83698, a potent and selective inhibitor of peptide deformylase, was the first compound of this novel antibacterial class to progress to clinical trials. Single- and/or multiple-dose studies with doses ranging from 10 to 50 mg of BB-83698/kg of bod

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cb5d3fa958c44e66df2bf8ee9ca75ec
https://doi.org/10.1128/aac.48.12.4835-4842.2004

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A Double‐Blind, Randomized, Controlled Trial of Amphotericin B Colloidal Dispersion versus Amphotericin B for Treatment of Invasive Aspergillosis in Immunocompromised Patients

Autor: Xin Li, Pranatharthi H. Chandrasekar, L. Pietrelli, Michel Laverdière, Sharon Safrin, Raleigh A. Bowden, Jo Anne Van Burik, Mary H. White, John R. Wingard, Marc Gurwith

Publikováno v: Clinical Infectious Diseases. 35:359-366

We report a randomized, double-blind, multicenter trial in which amphotericin B colloidal dispersion (ABCD [Amphotec]; 6 mg/kg/day) was compared with amphotericin B (AmB; 1.0-1.5 mg/kg/day) for the treatment of invasive aspergillosis in 174 patients.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4794bb1eb83c2c1a947006e73c9993e5
https://doi.org/10.1086/341401

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A Multicenter Phase I/II Dose Escalation Study of Single-Dose Cidofovir Gel for Treatment of Recurrent Genital Herpes

Autor: Stephen D. Shafran, Howard S. Jaffe, Stephen L. Sacks, April Hughes, Sharon Safrin, Sylvie Trottier, Francisco Diaz-Mitoma, Brian McGuire, R. Gary Sibbald, Jeff Rudy

Publikováno v: Antimicrobial Agents and Chemotherapy. 42:2996-2999

A randomized, double-blind, clinic-initiated, sequential dose-escalation pilot study was performed to compare the safety and efficacy of single applications of 1, 3, and 5% cidofovir gel with placebo in the treatment of early, lesional, recurrent gen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55ec022d2f572bbdfe01a35e8e749e12
https://doi.org/10.1128/aac.42.11.2996

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Safety, Pharmacokinetics, and Antiretroviral Activity of Intravenous 9-[2-( R )-(Phosphonomethoxy)propyl]adenine, a Novel Anti-Human Immunodeficiency Virus (HIV) Therapy, in HIV-Infected Adults

Autor: James O. Kahn, Frances Hwang, Nicholas S. Hellmann, Kenneth C. Cundy, Patricia Barditch-Crovo, Paul S. Lietman, James F. Rooney, Steven G. Deeks, Sharon Safrin

Publikováno v: Antimicrobial Agents and Chemotherapy. 42:2380-2384

9-[2-( R )-(Phosphonomethoxy)propyl]adenine (PMPA) is a nucleotide analogue with potent antiretroviral activity in vitro and in simian models. A randomized, double-blind, placebo-controlled, dose-escalation clinical trial of intravenous PMPA monother

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::000507796a245e6df9ae995d62e39bda
https://doi.org/10.1128/aac.42.9.2380

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Association Between Cryptosporidium Infection and Animal Exposure in HIV-Infected Individuals

Autor: Arthur Reingold, Thomas B. Newman, Sharon Safrin, Carol A. Glaser

Publikováno v: Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology. 17:79-82

Cryptosporidium causes a debilitating illness in immunocompromised individuals, yet the source of sporadic Cryptosporidium infections is unknown. Because early cases of cryptosporidiosis were associated with animals, and pets are a source of companio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61c6ddb2ea1f112e382d32275d6ae482
https://doi.org/10.1097/00042560-199801010-00012

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A Randomized, Double‐Blind, Placebo‐Controlled Trial of Cidofovir Gel for the Treatment of Acyclovir‐Unresponsive Mucocutaneous Herpes Simplex Virus Infection in Patients with AIDS

Autor: Timothy W. Schacker, Brian McGuire, Joseph Gathe, Sharon Safrin, Howard S. Jaffe, Francoise Kramer, Tony Cheung, Judith Feinberg, Harold A. Kessler, John Boggs, Lawrence Corey, W. Lawrence Drew, Jacob Lalezari, Sabina Lee

Publikováno v: The Journal of Infectious Diseases. 176:892-898

The safety and efficacy of cidofovir gel for treatment of acyclovir-unresponsive herpes simplex virus infections in AIDS patients was evaluated in a randomized, double-blind, multicenter trial. Cidofovir (0.3% or 1%) or placebo gel was applied once d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcbd13d4ab4c18e93af7fc82a4d007bd
https://doi.org/10.1086/516542

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Clinical uses of cidofovir

Autor: Howard S. Jaffe, Sharon Safrin, Julie M. Cherrington

Publikováno v: Reviews in Medical Virology. 7:145-156

Cidofovir is a cytidine nucleotide analogue recently licensed as an intravenous treatment for CMV retinitis in AIDS patients. Three controlled clinical trials have demonstrated efficacy of cidofovir for this indication, and have generated data useful

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e7da603338b6a5e685295a23ac8a9b7c
https://doi.org/10.1002/(sici)1099-1654(199709)7:3<145::aid-rmv196>3.0.co

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Comparison of Virus Culture and the Polymerase Chain Reaction for Diagnosis of Mucocutaneous Herpes Simplex Virus Infection

Autor: Jose Cuan, Gail Bolan, Sharon Safrin, Howard Shaw, Chiang Chih-Sheng

Publikováno v: Sexually Transmitted Diseases. 24:176-180

Background and Objectives: The diagnosis of mucocutaneous herpes simplex virus (HSV) is hampered by suboptimal sensitivity of virus culture and atypical clinical morphology. Goals: To compare the diagnostic usefulness of the polymerase chain reaction

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4023a95a7cd652ba73b5e7777e9b23b4
https://doi.org/10.1097/00007435-199703000-00010

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