Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Sharon S. McDaniel"'
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e57445 (2013)
Epilepsy is a common neurological disorder and cause of significant morbidity and mortality. Although antiseizure medication is the first-line treatment for epilepsy, currently available medications are ineffective in a significant percentage of pati
Externí odkaz:
https://doaj.org/article/ce9b250c01b547a48eec117bf37420e8
Autor:
Carleton Goold, Nadia Solovieff, William B. Dobyns, Richard A. Gibbs, Elisa Rahikkala, Jonathan D. Biag, Colleen F. Macmurdo, Eric Boerwinkle, Sonya A. Gunter, Sandra L. Poliachik, Brian H.Y. Chung, Christine D. Wilson, Evan A. Boyle, Scott Mahan, Robert F. Hevner, Russell P. Saneto, Katta M. Girisha, Rebecca Leary, Wendy Winckler, Molly Weaver, Sharon S. McDaniel, Jay Shendure, Laura A. Jansen, Shanming Liu, Shalini N. Jhangiani, Andrew E. Timms, William R. Sellers, Gisele Ishak, Michael Morrissey, Michael O. Dorschner, Donna M. Muzny, Catarina D. Campbell, Jeffrey G. Ojemann, Beth Martin, Edward J. Novotny, Renzo Guerrini, Ghayda M. Mirzaa, Leon Murphy, Valerio Conti, Jonathan A. Bernstein, James R. Lupski, Sarah Collins, Suchithra Menon, Carissa Olds, Kit San Yeung
Publikováno v:
JAMA neurology. 73(7)
Importance Focal cortical dysplasia (FCD), hemimegalencephaly, and megalencephaly constitute a spectrum of malformations of cortical development with shared neuropathologic features. These disorders are associated with significant childhood morbidity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c7d0a49983a07e254d5281c050e787f
https://pubmed.ncbi.nlm.nih.gov/27158974
https://pubmed.ncbi.nlm.nih.gov/27158974
Autor:
Andrew Poliakov, Edward J. Novotny, Carter D. Wray, Sharon S. McDaniel, Tim Blakely, Kai J. Miller, Jeffrey G. Ojemann, Sandra L. Poliachik
Publikováno v:
Journal of Neurosurgery: Pediatrics. 10:1-6
Object The gold-standard method for determining cortical functional organization in the context of neurosurgical intervention is electrical cortical stimulation (ECS), which disrupts normal cortical function to evoke movement. This technique is impre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::37f9c70e1bd1fc82d3ebfea2776892f4
https://doi.org/10.3171/2012.3.peds11554
https://doi.org/10.3171/2012.3.peds11554
Publikováno v:
Journal of Neurosurgery: Pediatrics. 9:546-551
Object Intraoperative electrocorticography (ECoG) is commonly used to guide the extent of resection, especially in lesion-associated intractable epilepsy. Interictal epileptiform discharges on postresective ECoG (post-ECoG) have been predictive of se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4ecfe9ae846b79f5ccbc531a41687bd2
https://doi.org/10.3171/2012.1.peds11441
https://doi.org/10.3171/2012.1.peds11441
Autor:
Jeffrey G. Ojemann, Seth D. Friedman, Sandra L. Poliachik, Dennis W. W. Shaw, Sharon S. McDaniel, Andrew Poliakov, Edward J. Novotny, Gisele E. Ishak, Russell P. Saneto
Publikováno v:
AJNR Am J Neuroradiol
BACKGROUND AND PURPOSE: Often diagnosed at birth or in early childhood, mitochondrial disease presents with a variety of clinical symptoms, particularly in organs and tissues that require high energetic demand such as brain, heart, liver, and skeleta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30cc387904f345aefba6b802cc26f22c
https://doi.org/10.3174/ajnr.a3045
https://doi.org/10.3174/ajnr.a3045
Publikováno v:
Epilepsia. 52:e7-e11
The ketogenic diet (KD) is an effective treatment for epilepsy, but its mechanisms of action are poorly understood. We investigated the hypothesis that the KD inhibits mammalian target of rapamycin (mTOR) pathway signaling. The expression of pS6 and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::78d5df4986ae14d0632134f7ef1dd232
https://doi.org/10.1111/j.1528-1167.2011.02981.x
https://doi.org/10.1111/j.1528-1167.2011.02981.x
Publikováno v:
Cell Cycle. 9:2281-2285
Identification of cell signaling mechanisms mediating seizure-related neuronal death and epileptogenesis is important for developing more effective therapies for epilepsy. The mammalian target of rapamycin (mTOR) pathway has recently been implicated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::690ce8804d4d1734d53847d42403dde3
https://doi.org/10.4161/cc.9.12.11866
https://doi.org/10.4161/cc.9.12.11866
Autor:
Miriam H. Meisler, Yvonne W. Wu, Joseph Sullivan, Eileen M. Walsh, Michael W. Kuzniewicz, Sharon S. McDaniel, Sherian Xu Li
Publikováno v:
Pediatrics, vol 136, iss 5
OBJECTIVE: De novo mutations of the gene sodium channel 1α (SCN1A) are the major cause of Dravet syndrome, an infantile epileptic encephalopathy. US incidence of DS has been estimated at 1 in 40 000, but no US epidemiologic studies have been perform
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::304cbe5657d7cd3cc7c9df207df63a4c
https://pubmed.ncbi.nlm.nih.gov/26438699
https://pubmed.ncbi.nlm.nih.gov/26438699
Autor:
Shen Zhang, Jason X.-J. Yuan, Ying Yu, Oleksandr Platoshyn, Michele Sweeney, Sharon S. McDaniel
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 283:L144-L155
Pulmonary vascular medial hypertrophy due to proliferation of pulmonary artery smooth muscle cells (PASMC) greatly contributes to the increased pulmonary vascular resistance in pulmonary hypertension patients. A rise in cytosolic free Ca2+concentrati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67eba79b8c9a1d02981a3fa2bd0060fb
https://doi.org/10.1152/ajplung.00412.2001
https://doi.org/10.1152/ajplung.00412.2001
Autor:
Patricia A. Thistlethwaite, Ying Zhao, Bethany R. Lapp, Sharon S. McDaniel, Oleksandr Platoshyn, Ying Yu, Jason X.-J. Yuan, Shen Zhang, Michele Sweeney
Publikováno v:
Journal of Applied Physiology. 92:1594-1602
Asthma is characterized by airway inflammation, bronchial hyperresponsiveness, and airway obstruction by bronchospasm and bronchial wall thickening due to smooth muscle hypertrophy. A rise in cytosolic free Ca2+concentration ([Ca2+]cyt) may serve as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50692b3ea6a19c526f3bed82f3132c63
https://doi.org/10.1152/japplphysiol.00722.2001
https://doi.org/10.1152/japplphysiol.00722.2001