Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Sharon S Lander"'
Autor:
Amanda C. Mitchell, Behnam Javidfar, Lucy K. Bicks, Rachael Neve, Krassimira Garbett, Sharon S. Lander, Karoly Mirnics, Hirofumi Morishita, Marcelo A. Wood, Yan Jiang, Inna Gaisler-Salomon, Schahram Akbarian
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
Chromosome conformation is a dynamic process, especially in brain. Here, Mitchell and colleagues devise a method they call NeuroDam that can prospectively tag chromosome conformation in the mouse brain in vivo, and longitudinally assess long range ch
Externí odkaz:
https://doaj.org/article/f253420b0f734648a73d3166c76192e2
Autor:
Sharon S Lander, Amit Gross, Inna Gaisler-Salomon, Herman Wolosker, Sergiy Chornyy, Hazem Safory
Publikováno v:
Genes, brain, and behaviorREFERENCES. 19(6)
Glutamate Dehydrogenase 1 (GDH), encoded by the Glud1 gene in rodents, is a mitochondrial enzyme critical for maintaining glutamate homeostasis at the tripartite synapse. Our previous studies indicate that the hippocampus may be particularly vulnerab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b1b65fee6d1f29483b93765fd9a0554
https://pubmed.ncbi.nlm.nih.gov/31898404
https://pubmed.ncbi.nlm.nih.gov/31898404
Autor:
Hanoch Kaphzan, Sharon S Lander, Inna Gaisler-Salomon, Darpan Chakraborty, Herman Wolosker, Kfir Asraf, Hazem Safory
BACKGROUND: Glutamatergic abnormalities are commonly observed in schizophrenia (SZ) and are hypothesized to play an important role in cognitive dysfunction. While the contribution of postsynaptic glutamate receptors to SZ psychopathology has been ext
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a52c903e6b5172df8de0d822399c471
https://europepmc.org/articles/PMC6455389/
https://europepmc.org/articles/PMC6455389/
Autor:
Inna Gaisler-Salomon, Sergiy Chornyy, Hanoch Kaphzan, Sharon S Lander, Scott A. Small, Nicole M. Lewandowski, Frank A. Provenzano, Stephen Rayport, Francesca Frigerio, Susana Mingote, Darpan Chakraborty, Pierre Maechler, Usman A. Khan
Publikováno v:
Schizophrenia Bulletin, Vol. 45, No 1 (2019) pp. 127-137
Brain imaging has revealed that the CA1 subregion of the hippocampus is hyperactive in prodromal and diagnosed patients with schizophrenia (SCZ), and that glutamate is a driver of this hyperactivity. Strikingly, mice deficient in the glutamate synthe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41be438b310ef516412427e8f37d5d17
https://europepmc.org/articles/PMC6293228/
https://europepmc.org/articles/PMC6293228/
Autor:
Sharon S Lander, Rachael L. Neve, Lucy K. Bicks, Krassimira A. Garbett, Yan Jiang, Schahram Akbarian, Amanda C. Mitchell, Karoly Mirnics, Behnam Javidfar, Hirofumi Morishita, Marcelo A. Wood, Inna Gaisler-Salomon
Publikováno v:
Nature Communications
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
Mitchell, AC; Javidfar, B; Bicks, LK; Neve, R; Garbett, K; Lander, SS; et al.(2016). Longitudinal assessment of neuronal 3D genomes in mouse prefrontal cortex. NATURE COMMUNICATIONS, 7. doi: 10.1038/ncomms12743. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/0sw590pg
Nature
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
Mitchell, AC; Javidfar, B; Bicks, LK; Neve, R; Garbett, K; Lander, SS; et al.(2016). Longitudinal assessment of neuronal 3D genomes in mouse prefrontal cortex. NATURE COMMUNICATIONS, 7. doi: 10.1038/ncomms12743. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/0sw590pg
Nature
Neuronal epigenomes, including chromosomal loopings moving distal cis-regulatory elements into proximity of target genes, could serve as molecular proxy linking present-day-behaviour to past exposures. However, longitudinal assessment of chromatin st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::594b8cb3d9dd2a7071cd2dee6b76a402
http://europepmc.org/articles/PMC5025847
http://europepmc.org/articles/PMC5025847
Publikováno v:
Behavioural brain research. 316
Intact function of the medial prefrontal cortex (mPFC) function relies on proper development of excitatory and inhibitory neuronal populations and on integral myelination processes. Social isolation (SI) affects behavior and brain circuitry in adulth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8c1c8e21ccc213fb11c9e38d0f3627c
https://pubmed.ncbi.nlm.nih.gov/27618762
https://pubmed.ncbi.nlm.nih.gov/27618762
Autor:
Pierre Maechler, Stephen Rayport, Hanoch Kaphzan, Sharon S Lander, Reut Donner, Susana Mingote, Scott A. Small, Frank A. Provenzano, Nicole M. Lewandowski, Darpan Chakraborti, Inna Gaisler-Salomon
Publikováno v:
Schizophrenia Bulletin. 43:S109-S110
Background: Glutamatergic abnormalities are commonly observed in schizophrenia (SZ), but all current medications for SZ symptoms target monoaminergic neurotransmitter systems, and are inefficient in treating all symptom clusters. Animal models that c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8c015ec34a874f141c1bd0b6d0b1925
https://doi.org/10.1093/schbul/sbx021.294
https://doi.org/10.1093/schbul/sbx021.294
Publikováno v:
Schizophrenia Bulletin
Background Dysregulated glutamatergic neurotransmission has been strongly implicated in the pathology of schizophrenia (SZ). Glutaminase 1 (GLS1) plays a critical role in the recycling of glutamate. GLS1 deficient mice were previously shown to displa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02bc3244ad34a09a2cca111cf4843a88
https://doi.org/10.1093/schbul/sby016.496
https://doi.org/10.1093/schbul/sby016.496
Autor:
Lander, Sharon S, Khan, Usman, Lewandowski, Nicole, Chakraborty, Darpan, Provenzano, Frank A, Mingote, Susana, Chornyy, Sergiy, Frigerio, Francesca, Maechler, Pierre, Kaphzan, Hanoch, Small, Scott A, Rayport, Stephen, Gaisler-Salomon, Inna
Publikováno v:
Schizophrenia Bulletin; Jan2019, Vol. 45 Issue 1, p127-137, 11p, 1 Diagram, 3 Graphs