Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Sharon R. Myers"'
Autor:
Andrew C Adams, Carolyn A Halstead, Barbara C Hansen, Armando R Irizarry, Jennifer A Martin, Sharon R Myers, Vincent L Reynolds, Holly W Smith, Victor J Wroblewski, Alexei Kharitonenkov
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e65763 (2013)
Fibroblast growth factor 21 (FGF21) is a novel metabolic regulator that represents a promising target for the treatment of several metabolic diseases. Administration of recombinant wild type FGF21 to diabetic animals leads to a dramatic improvement i
Externí odkaz:
https://doaj.org/article/aa7072c111da48b3972a0347777f6348
Autor:
Amy L. Cox, Ronald E. Chance, David S. McClellan, Sharon R. Myers, Mark L. Brader, Allen H. Pekar, David B. Flora, Lynnie A. Irwin, Muppalla Sukumar
Publikováno v:
Nature Biotechnology. 20:800-804
The ability to tailor the release profile of a drug by manipulating its formulation matrix offers important therapeutic advantages. We show here that human insulin can be cocrystallized at preselected ratios with the fully active lipophilically modif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8790eb3ca0b2a121ab35819f7e94f75a
https://doi.org/10.1038/nbt722
https://doi.org/10.1038/nbt722
Autor:
Kevin A. Destrampe, Dawn Marie Rebhun, Dean K. Clodfelter, Allen H. Pekar, Sharon R. Myers, Henry A. Havel, Mark L. Brader
Publikováno v:
Pharmaceutical Research. 15:254-262
Purpose. To utilize an acylated peptide as a model system to investigate the relationships among solution peptide conformation, non-covalent self-association, subcutaneous absorption and bioavailability under pharmaceutically relevant solution formul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9ddb2e63eb4d17339e3b31c3ec05dd98
https://doi.org/10.1023/a:1011918719017
https://doi.org/10.1023/a:1011918719017
Autor:
Doss W. Neal, Sharon R Myers, Cynthia C. Connolly, Jonathan B. Jaspan, R. T. Frizzell, Alan D. Cherrington, Stephen N. Davis, D. W. Biggers, E. M. Jones
Publikováno v:
Diabetes. 42:1253-1261
Previous studies have demonstrated the importance of the brain in directing counterregulation during insulin-induced hypoglycemia in dogs. The capability of selective carotid or vertebrobasilar hypoglycemia in triggering counterregulation was assesse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::042e93d94c24178a4b19a4f4ae7d667f
https://doi.org/10.2337/diab.42.9.1253
https://doi.org/10.2337/diab.42.9.1253
Publikováno v:
Journal of Clinical Investigation. 87:930-939
To examine the relationship between net hepatic glucose uptake (NHGU) and the insulin level and to determine the effects of portal glucose delivery on that relationship, NHGU was evaluated at three different insulin levels in seven 42-h-fasted, consc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a0b163d2ee207b5e9e4678e5598e157
https://doi.org/10.1172/jci115100
https://doi.org/10.1172/jci115100
Autor:
Michael P. Diamond, Sharon R Myers, Bess A. Adkins-Marshall, Randy Stinsen, Alan D. Cherrington, Phillip E. Williams
Publikováno v:
Metabolism. 40:66-71
The aim of this study was to examine the influence of small changes in glucagon on hepatic glucose production during a euglycemic, hyperinsulinemic clamp. During 1.0 mU/kg.min insulin infusion, euglycemia was maintained by glucose infusion and glucag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a97bef2da751b126169b824594bdfe8d
https://doi.org/10.1016/0026-0495(91)90194-2
https://doi.org/10.1016/0026-0495(91)90194-2
Autor:
Phil Williams, Bess A. Adkins-Marshall, Sharon R Myers, Keith Triebwasser, Ben Floyd, Alan D. Cherrington, G K Hendrick
Publikováno v:
Diabetes. 39:87-95
In the presence of fixed basal levels of insulin, the route of intravenous glucose delivery (portal vs. peripheral) determines whether net hepatic glucose uptake (NHGU) occurs. Our aims were to determine if the route of intravenous glucose delivery a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85c330f31fa58fc5f6201065d68fe836
https://doi.org/10.2337/diacare.39.1.87
https://doi.org/10.2337/diacare.39.1.87
Autor:
Carolyn A. Halstead, Vincent L. Reynolds, Sharon R. Myers, Holly W. Smith, Armando R. Irizarry, Alexei Kharitonenkov, Victor J. Wroblewski, Barbara C. Hansen, Andrew C. Adams, Jennifer A. Martin
Publikováno v:
PLoS ONE
PLoS ONE, Vol 8, Iss 6, p e65763 (2013)
PLoS ONE, Vol 8, Iss 6, p e65763 (2013)
Fibroblast growth factor 21 (FGF21) is a novel metabolic regulator that represents a promising target for the treatment of several metabolic diseases. Administration of recombinant wild type FGF21 to diabetic animals leads to a dramatic improvement i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::862f7e97911270f9c9ec3acc0164e5dc
https://doi.org/10.1371/journal.pone.0065763
https://doi.org/10.1371/journal.pone.0065763
Publikováno v:
Diabetes. 45(12)
We have previously demonstrated that the liver can release glucose in response to insulin-induced hypoglycemia, despite the absence of glucagon, epinephrine, cortisol, and growth hormone. The aim of this study was to determine whether this is activat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6cac22ee9ba405dba75f8975e2e99b1
https://pubmed.ncbi.nlm.nih.gov/8922369
https://pubmed.ncbi.nlm.nih.gov/8922369
Autor:
Cynthia C. Connolly, Alan D. Cherrington, G. K. Hendrick, Bess A. Adkins-Marshall, Doss W. Neal, Phillip E. Williams, Sharon R Myers, R. B. Adkins, Jordan Asher, Michael J. Pagliassotti
Publikováno v:
The American journal of physiology. 262(5 Pt 1)
Net hepatic glucose uptake (NHGU) is much greater during oral or intraportal glucose loading than during peripheral intravenous glucose delivery even when similar glucose loads and hormone levels reaching the liver are maintained. To determine whethe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ebc0f546c139a1724b5458b8f677875
https://pubmed.ncbi.nlm.nih.gov/1590377
https://pubmed.ncbi.nlm.nih.gov/1590377