Zobrazeno 1 - 10
of 481
pro vyhledávání: '"Sharon R. Lewin"'
Autor:
David W. J. Griffin, Michael Dymock, Germaine Wong, C. Orla Morrissey, Sharon R. Lewin, Allen C. Cheng, Kirsten Howard, Julie A. Marsh, Kanta Subbarao, Michelle Hagenauer, Janine Roney, Anthony Cunningham, Tom Snelling, James H. McMahon
Publikováno v:
Trials, Vol 25, Iss 1, Pp 1-12 (2024)
Abstract Background Immunocompromised hosts (ICH) experience more breakthrough infections and worse clinical outcomes following infection with COVID-19 than immunocompetent people. Prophylactic monoclonal antibody therapies can be challenging to acce
Externí odkaz:
https://doaj.org/article/1be3382a6889486ca70a589275975189
Autor:
George Taiaroa, Doris Chibo, Sophie Herman, Mona L. Taouk, Megan Gooey, Jodie D'Costa, Rizmina Sameer, Nicole Richards, Elaine Lee, Lydya Macksabo, Nasra Higgins, David J. Price, Soo Jen Low, Eike Steinig, Genevieve E. Martin, Michael A. Moso, Leon Caly, Jacqueline Prestedge, Christopher K. Fairley, Eric P.F. Chow, Marcus Y. Chen, Sebastian Duchene, Jane S. Hocking, Sharon R. Lewin, Deborah A. Williamson
Publikováno v:
The Lancet Regional Health. Western Pacific, Vol 47, Iss , Pp 101103- (2024)
Summary: Background: In Australia the incidence of HIV has declined steadily, yet sustained reduction of HIV transmission in this setting requires improved public health responses. As enhanced public health responses and prioritisation of resources m
Externí odkaz:
https://doaj.org/article/3fc2c314c672401ab197139c9f36b1ae
Autor:
Kasha P. Singh, Anchalee Avihingsanon, Jennifer M. Zerbato, Wei Zhao, Sabine Braat, Surekha Tennakoon, Ajantha Rhodes, Gail V. Matthews, Christopher K. Fairley, Joe Sasadeusz, Megan Crane, Jennifer Audsley, Sharon R. Lewin
Publikováno v:
EBioMedicine, Vol 102, Iss , Pp 105054- (2024)
Summary: Background: In people living with HIV-HBV, liver fibrosis progression can occur even with suppressive antiretroviral therapy (ART). We investigated the relationship between liver fibrosis and biomarkers of inflammation, apoptosis, and microb
Externí odkaz:
https://doaj.org/article/118a4cf1f7454af0a836c04c8076cde0
Autor:
Terry M. Nolan, Georgia Deliyannis, Maryanne Griffith, Sabine Braat, Lilith F. Allen, Jennifer Audsley, Amy W. Chung, Marcin Ciula, Nicholas A. Gherardin, Michelle L. Giles, Tom P. Gordon, Samantha L. Grimley, Lana Horng, David C. Jackson, Jennifer A. Juno, Katherine Kedzierska, Stephen J. Kent, Sharon R. Lewin, Mason Littlejohn, Hayley A. McQuilten, Francesca L. Mordant, Thi H.O. Nguyen, Vanessa Pac Soo, Briony Price, Damian F.J. Purcell, Pradhipa Ramanathan, Samuel J. Redmond, Steven Rockman, Zheng Ruan, Joseph Sasadeusz, Julie A. Simpson, Kanta Subbarao, Stewart A. Fabb, Thomas J. Payne, Asuka Takanashi, Chee Wah Tan, Joseph Torresi, Jing Jing Wang, Lin-Fa Wang, Hareth Al-Wassiti, Chinn Yi Wong, Sophie Zaloumis, Colin W. Pouton, Dale I. Godfrey
Publikováno v:
EBioMedicine, Vol 98, Iss , Pp 104878- (2023)
Summary: Background: SARS-CoV-2 booster vaccination should ideally enhance protection against variants and minimise immune imprinting. This Phase I trial evaluated two vaccines targeting SARS-CoV-2 beta-variant receptor-binding domain (RBD): a recomb
Externí odkaz:
https://doaj.org/article/759603e2b16e4eff9551a0f453f831d4
Publikováno v:
Journal of Virus Eradication, Vol 9, Iss 3, Pp 100344- (2023)
With growing interest and efforts to achieve a hepatitis B (HBV) cure, HBV therapeutics have increasingly entered the clinical testing phase. In designing an early phase clinical trial aimed at HBV cure, the heterogeneity in participants and the choi
Externí odkaz:
https://doaj.org/article/9dce22d229e14040b053f2416f38fc9b
Autor:
Matthew C. Pitman, Niamh Meagher, David J. Price, Ajantha Rhodes, J. Judy Chang, Barbara Scher, Brent Allan, Alan Street, James H. McMahon, Thomas A. Rasmussen, Paul U. Cameron, Jennifer F. Hoy, Stephen J. Kent, Sharon R. Lewin
Publikováno v:
Journal of Virus Eradication, Vol 9, Iss 3, Pp 100345- (2023)
Introduction: Antiretroviral therapy for people living with HIV-1 must be taken lifelong due to the persistence of latent virus in long-lived and proliferating CD4+ T cells. Vitamin D3 is a steroidal gene transcription regulator which exerts diverse
Externí odkaz:
https://doaj.org/article/d855402a478d4c80a0f9d2f7a2dcf56a
Autor:
Carolin Tumpach, Catherine R. Cochrane, Youry Kim, Jesslyn Ong, Ajantha Rhodes, Thomas A. Angelovich, Melissa J. Churchill, Sharon R. Lewin, Sushama Telwatte, Michael Roche
Publikováno v:
Journal of Virus Eradication, Vol 9, Iss 2, Pp 100335- (2023)
Quantification of intact proviruses is a critical measurement in HIV cure studies both in vitro and in vivo. The widely adopted ‘intact proviral DNA assay’ (IPDA), designed to discriminate and quantify genetically intact HIV proviruses based on d
Externí odkaz:
https://doaj.org/article/9667ec6b75ac4d299079c26788a17b22
Autor:
Georgia Deliyannis, Nicholas A. Gherardin, Chinn Yi Wong, Samantha L. Grimley, James P. Cooney, Samuel J. Redmond, Paula Ellenberg, Kathryn C. Davidson, Francesca L. Mordant, Tim Smith, Marianne Gillard, Ester Lopez, Julie McAuley, Chee Wah Tan, Jing J. Wang, Weiguang Zeng, Mason Littlejohn, Runhong Zhou, Jasper Fuk-Woo Chan, Zhi-wei Chen, Airn E. Hartwig, Richard Bowen, Jason M. Mackenzie, Elizabeth Vincan, Joseph Torresi, Katherine Kedzierska, Colin W. Pouton, Tom P. Gordon, Lin-fa Wang, Stephen J. Kent, Adam K. Wheatley, Sharon R. Lewin, Kanta Subbarao, Amy W. Chung, Marc Pellegrini, Trent Munro, Terry Nolan, Steven Rockman, David C. Jackson, Damian F.J. Purcell, Dale I. Godfrey
Publikováno v:
EBioMedicine, Vol 92, Iss , Pp 104574- (2023)
Summary: Background: The SARS-CoV-2 global pandemic has fuelled the generation of vaccines at an unprecedented pace and scale. However, many challenges remain, including: the emergence of vaccine-resistant mutant viruses, vaccine stability during sto
Externí odkaz:
https://doaj.org/article/3f8a77f37e1f498db21c0e05005ef2d3
Autor:
Chris Y. Chiu, Maya D. Schou, James H. McMahon, Steven G. Deeks, Rémi Fromentin, Nicolas Chomont, Michelle N. Wykes, Thomas A. Rasmussen, Sharon R. Lewin
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionIn people with HIV (PWH) both off and on antiretroviral therapy (ART), the expression of immune checkpoint (IC) proteins is elevated on the surface of total and HIV-specific T-cells, indicating T-cell exhaustion. Soluble IC proteins and t
Externí odkaz:
https://doaj.org/article/64a3fccd9520467d87cf447a13d006fc
Autor:
Katie Fisher, Timothy E. Schlub, Zoe Boyer, Thomas A. Rasmussen, Ajantha Rhodes, Rebecca Hoh, Frederick M. Hecht, Steven G. Deeks, Sharon R. Lewin, Sarah Palmer
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionHIV-1 persists in resting CD4+ T-cells despite antiretroviral therapy (ART). Determining the cell surface markers that enrich for genetically-intact HIV-1 genomes is vital in developing targeted curative strategies. Previous studies have
Externí odkaz:
https://doaj.org/article/8ab70143506b4063b3093bbe3bac76ac