Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Sharon Miksys"'
Autor:
Ahmed Hasbi, Tuan Nguyen, Haneen Rahal, Joshua D. Manduca, Sharon Miksys, Rachel F. Tyndale, Bertha K. Madras, Melissa L. Perreault, Susan R. George
Publikováno v:
Biology of Sex Differences, Vol 11, Iss 1, Pp 1-17 (2020)
Abstract Depression and anxiety are more common among females than males and represent a leading cause of disease-related disability in women. Since the dopamine D1-D2 heteromer is involved in depression- and anxiety-like behavior, the possibility th
Externí odkaz:
https://doaj.org/article/3298301a82ff4b089393019ba22e13bd
Autor:
Ian Mahar, Rosemary C Bagot, Maria Antonietta Davoli, Sharon Miksys, Rachel F Tyndale, Claire-Dominique Walker, Marissa Maheu, Sheng-Hai Huang, Tak Pan Wong, Naguib Mechawar
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e37219 (2012)
The influence of developmental nicotine exposure on the brain represents an important health topic in light of the popularity of nicotine replacement therapy (NRT) as a smoking cessation method during pregnancy.In this study, we used a model of NRT d
Externí odkaz:
https://doaj.org/article/df1c9426053b475295e314d66883f37b
Publikováno v:
Mol Neurobiol
Sex differences in opioid analgesia occur in rodents and humans, and could be due to differences in drug and metabolite levels. Thus, we investigated the sex and cycle differences in analgesia (nociception) from oxycodone in rats and related these to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85d832a000b9acaf38a742eaa5c0f606
https://doi.org/10.1007/s12035-021-02560-1
https://doi.org/10.1007/s12035-021-02560-1
Publikováno v:
Neuropharmacology. 221
Cytochrome P450 2D (CYP2D) metabolises many centrally-acting substrates including opioids. Hydrocodone, an opioid and CYP2D substrate, is metabolised to hydromorphone, an active metabolite. CYP2D in the brain is active in vivo and can alter drug resp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::354722a9c59a52ba0cea0dd0c4e648a5
https://pubmed.ncbi.nlm.nih.gov/36241086
https://pubmed.ncbi.nlm.nih.gov/36241086
Publikováno v:
Mol Neurobiol
CYP2D metabolizes many drugs that act within the brain, and variable expression of CYP2D in the brain may alter local drug and metabolite levels sufficiently to affect behavioral responses. Transgenic mice that express human CYP2D6 (TG) were compared
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b99adeb80592223f6339b7cd09ca5b7
https://doi.org/10.1007/s12035-020-01896-4
https://doi.org/10.1007/s12035-020-01896-4
Autor:
Filip Milosavljević, Irene Brusini, Andrea Atanasov, Marina Manojlović, Maria Novalen, Marija Vučić, Zorana Oreščanin Dušić, Jelena Brkljačić, Sharon Miksys, Čedo Miljević, Aleksandra Nikolić, Duško Blagojević, Chunliang Wang, Peter Damberg, Vesna Pešić, Rachel F Tyndale, Magnus Ingelman-Sundberg, Marin M Jukić
BackgroundAnimal models are essential for understanding etiology and pathophysiology of movement disorders. Previously, we have found that mice transgenic for the human CYP2C19 gene, expressed in the liver and developing brain, exhibit altered neurod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c80c641bb8bf67b5768b339751dcc61f
https://doi.org/10.1101/2022.01.10.475612
https://doi.org/10.1101/2022.01.10.475612
Publikováno v:
Biochem Pharmacol
Opioids, and numerous centrally active drugs, are metabolized by cytochrome P450 2D (CYP2D). There are sex and estrous cycle differences in brain oxycodone analgesia. Here we investigated the mechanism examining the selective role of CYP2D in the bra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a412cda5f3a3114bab750a6f4d5c49a
https://pubmed.ncbi.nlm.nih.gov/35143755
https://pubmed.ncbi.nlm.nih.gov/35143755
Autor:
Marlaina R. Stocco, Frank J. Gonzalez, Sharon Miksys, Cole Tolledo, Rachel F. Tyndale, Fariba Baghai Wadji
Publikováno v:
Mol Neurobiol
CYP2D6 metabolically inactivates several neurotoxins, including beta-carbolines, which are implicated in neurodegenerative diseases. Variation in CYP2D6 within the brain may alter local inactivation of neurotoxic beta-carbolines, thereby influencing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::944d1d52761a7039c8e0a0d063c64983
https://europepmc.org/articles/PMC8865091/
https://europepmc.org/articles/PMC8865091/
CYP2A enzymes metabolically inactivate nicotine and activate tobacco-derived procarcinogens [e.g., 4-[methylnitrosamino]-1-(3-pyridyl)-1-butanone]. Smoking decreases nicotine clearance, and chronic nicotine reduces hepatic CYP2A activity. However, li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::861874113252fad6a951d19e88dcdc22
https://doi.org/10.22541/au.159285510.07118043
https://doi.org/10.22541/au.159285510.07118043
Autor:
Haneen Rahal, Rachel F. Tyndale, Ahmed Hasbi, Bertha K. Madras, Joshua D. Manduca, Tuan V. Nguyen, Melissa L. Perreault, Sharon Miksys, Susan R. George
Publikováno v:
Biology of Sex Differences, Vol 11, Iss 1, Pp 1-17 (2020)
Biology of Sex Differences
Biology of Sex Differences
Depression and anxiety are more common among females than males and represent a leading cause of disease-related disability in women. Since the dopamine D1-D2 heteromer is involved in depression- and anxiety-like behavior, the possibility that the re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7645d207e0eddaa6fff840fe23337af0
https://doi.org/10.1186/s13293-020-00285-9
https://doi.org/10.1186/s13293-020-00285-9