Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Sharon Maguire"'
Autor:
Martin Pass, Sylvie Guichard, Graeme C.M. Smith, Matt Jacobsen, Richard Jenkins, Keith Menear, Karine Malagu, Marc Hummersone, Sharon Maguire, Lisa Smith, Gareth Hughes, Phillippa Dudley, Zoe Howard, Dominic James, Patrizia Sini, Darren Jones, Rebecca Ellston, John P. Vincent, Susan E. Critchlow, Sabina Cosulich, Tom Harding, Ian Hickson, Barry R. Davies, Christine M. Chresta
The mammalian target of rapamycin (mTOR) kinase forms two multiprotein complexes, mTORC1 and mTORC2, which regulate cell growth, cell survival, and autophagy. Allosteric inhibitors of mTORC1, such as rapamycin, have been extensively used to study tum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28f94cb2e112404bc4549d9a076de01b
https://doi.org/10.1158/0008-5472.c.6500190
https://doi.org/10.1158/0008-5472.c.6500190
Autor:
Martin Pass, Sylvie Guichard, Graeme C.M. Smith, Matt Jacobsen, Richard Jenkins, Keith Menear, Karine Malagu, Marc Hummersone, Sharon Maguire, Lisa Smith, Gareth Hughes, Phillippa Dudley, Zoe Howard, Dominic James, Patrizia Sini, Darren Jones, Rebecca Ellston, John P. Vincent, Susan E. Critchlow, Sabina Cosulich, Tom Harding, Ian Hickson, Barry R. Davies, Christine M. Chresta
Supplementary Table 1 from AZD8055 Is a Potent, Selective, and Orally Bioavailable ATP-Competitive Mammalian Target of Rapamycin Kinase Inhibitor with In vitro and In vivo Antitumor Activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3384b989c01cabca3f7bf94f2d6d0f8f
https://doi.org/10.1158/0008-5472.22382397.v1
https://doi.org/10.1158/0008-5472.22382397.v1
Autor:
Phillippa Dudley, Marc Geoffrey Hummersone, Lisa Smith, Sylvie Guichard, Patrizia Sini, Barry R. Davies, Zoe Howard, Gareth M. Hughes, Martin Pass, Matt Jacobsen, Sabina Cosulich, Ian Hickson, John Vincent, Dominic I. James, Darren Jones, Karine Malagu, Richard O. Jenkins, Graeme C. M. Smith, Rebecca Ellston, Sharon Maguire, Christine M. Chresta, Susan E. Critchlow, Thomas Harding, Keith Allan Menear
Publikováno v:
Cancer research. 70(1)
The mammalian target of rapamycin (mTOR) kinase forms two multiprotein complexes, mTORC1 and mTORC2, which regulate cell growth, cell survival, and autophagy. Allosteric inhibitors of mTORC1, such as rapamycin, have been extensively used to study tum
Autor:
Stephanie Maine, Niall M. B. Martin, Marc Geoffrey Hummersone, Carrie-Anne Molyneaux, Christine Bailey, Sharon Maguire, Frederic Georges Marie Leroux, Hermann Gesine Johanna, Graeme C. M. Smith, Ian Hickson, Mar Jimenez Quesada, James R. Pullen, Heather Mary Ellen Duggan, Keith Allan Menear, Peter D. Edwards, Martin Pass, Sylvie Gomez, Lisa Smith, Jan Drzewiecki, Karine Malagu, Armelle Le Gall
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(20)
We describe a novel series of potent inhibitors of the kinase activity of mTOR. The compounds display good selectivity relative to other PI3K-related kinase family members and, in cellular assays, inhibit both mTORC1 and mTORC2 complexes and exhibit
Publikováno v:
The International Journal of Diversity in Organizations, Communities, and Nations: Annual Review. 4
Autor:
Pia Thommes, Sylvie Guichard, J. Willem M. Nissink, A. Hughes, Elaine Brown, Xavier Jacq, Joana Boros, Dan Heathcote, Rajesh Odedra, Steve Powell, Jen Barnes, Philip J. Jewsbury, Sharon Maguire, Peter D. Caie, Victoria Pearson, Kevin Michael Foote, Lisa Smith
Publikováno v:
Cancer Research. 72:1823-1823
The DNA damage response (DDR) comprises a range of mechanisms that ensure the integrity of the genome. As part of the DDR and in response to specific DNA damage, the master kinases ATM, ATR and DNA-PK are activated in a coordinated fashion inducing c