Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Sharon Madzorera"'
Autor:
Thandeka Moyo-Gwete, Cathrine Scheepers, Zanele Makhado, Prudence Kgagudi, Nonkululeko B. Mzindle, Rutendo Ziki, Sharon Madzorera, Nelia P. Manamela, Frances Ayres, Bronwen E. Lambson, Simone I. Richardson, Lynn Morris, Penny L. Moore
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-9 (2022)
Abstract Antibodies with the same variable region can exist as multiple isotypes with varying neutralization potencies, though the mechanism for this is not fully defined. We previously isolated an HIV-directed IgA1 monoclonal antibody (mAb), CAP88-C
Externí odkaz:
https://doaj.org/article/c2c5fc6c15e34f56b2798fa353ccefee
Autor:
Shabir A. Madhi, Gaurav Kwatra, Richard Welch, Anthonet L. Koen, Vicky L. Baillie, Clare Cutland, Lee Fairlie, Sherman D. Padayachee, Keertan Dheda, Shaun L. Barnabas, Qasim Ebrahim Bhorat, Carmen Briner, Khatija Ahmed, Parvinder K. Aley, Sutika Bhikha, As'ad Ebrahim Bhorat, Aliasgar Esmail, Elizea Horne, Haajira Kaldine, Christian K. Mukendi, Vimbai Sharon Madzorera, Nelia P. Manamela, Mduduzi Masilela, Tandile Hermanus, Thopisang Motlou, Nonkululeko Mzindle, Suzette Oelofse, Faeezah Patel, Sarah Rhead, Lindie Rossouw, Carol Taoushanis, Samuel van Eck, Teresa Lambe, Sarah C. Gilbert, Andrew J. Pollard, Penny L. Moore, Alane Izu
Publikováno v:
SSRN Electronic Journal.
Autor:
Simone I. Richardson, Vimbai Sharon Madzorera, Holly Spencer, Nelia P. Manamela, Mieke A. van der Mescht, Bronwen E. Lambson, Brent Oosthuysen, Frances Ayres, Zanele Makhado, Thandeka Moyo-Gwete, Nonkululeko Mzindle, Thopisang Motlou, Amy Strydom, Adriano Mendes, Houriiyah Tegally, Zelda de Beer, Talita Roma de Villiers, Annie Bodenstein, Gretha van den Berg, Marietjie Venter, Tulio de Oliviera, Veronica Ueckermann, Theresa M. Rossouw, Michael T. Boswell, Penny L. Moore
Publikováno v:
Cell Host & Microbe. 30:880-886.e4
The SARS-CoV-2 Omicron variant escapes neutralizing antibodies elicited by vaccines or infection. However, whether Omicron triggers cross-reactive humoral responses to other variants of concern (VOCs) remains unknown. We use plasma from 20 unvaccinat
Autor:
Nicole A. Doria-Rose, Colin Anthony, Bronwen E. Lambson, J Bhiman, S. S. Abdool Karim, Lynn Morris, Brent Oosthuysen, Nigel Garrett, D Mvududu, Penelope L. Moore, Dale Kitchin, John R. Mascola, Sharon Madzorera
Publikováno v:
Virus Evolution
Broadly neutralizing antibodies (bNAbs) are essential for a preventative HIV-1 vaccine but have not been elicited through vaccination. bNAbs develop in 20–30 per cent of HIV-1 infections and often target the V3-glycan epitope of the HIV envelope pr
Autor:
William Kilembe, Iavi Protocol C Investigators, Bronwen E. Lambson, Sergey Menis, Molati Nonyane, Thomas Vollbrecht, Torben Schiffner, Sanjay Mohan, Sharon Madzorera, Trevor Biddle, Dale Kitchin, William R. Schief, Ben Murrell, Devin Sok, Bernard S. Bagaya, Bryan Briney, Karen L. Saye-Francisco, Dennis R. Burton, Collin Joyce, Elise Landais, Oleksander Kalyuzhniy, Pascal Poignard, Jeffrey C. Umotoy, Penny L. Moore
Publikováno v:
Immunity, 51(1), 141-154.e6. Cell Press
Immunity
Immunity
Summary The VH1-2 restricted VRC01-class of antibodies targeting the HIV envelope CD4 binding site are a major focus of HIV vaccine strategies. However, a detailed analysis of VRC01-class antibody development has been limited by the rare nature of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e0b6d02224b2f8a2191c94d8ee3daf3
https://pure.amc.nl/en/publications/rapid-and-focused-maturation-of-a-vrc01class-hiv-broadly-neutralizing-antibody-lineage-involves-both-binding-and-accommodation-of-the-n276glycan(dc781706-a044-4460-83cf-ef9d2610b65c).html
https://pure.amc.nl/en/publications/rapid-and-focused-maturation-of-a-vrc01class-hiv-broadly-neutralizing-antibody-lineage-involves-both-binding-and-accommodation-of-the-n276glycan(dc781706-a044-4460-83cf-ef9d2610b65c).html
Autor:
Jeffrey Umotoy, Bernard Bagaya, Collin Joyce, Sergey Menis, Torben Schiffner, Sanjay Mohan, Thomas Vollbrecht, Oleksander Kalyuzhniy, Sharon Madzorera, Dale Kitchin, Bronwen Lambson, Molati Nonyane, William Kilembe, The IAVI Protocol C Investigators, The IAVI African HIV Research Network, Pascal Poignard, William R. Schief, Dennis R. Burton, Ben Murrell, Penny L. Moore, Bryan Briney, Devin Sok, Elise Landais
Publikováno v:
SSRN Electronic Journal.
The VH1-2 restricted VRC01-class of antibodies targeting the HIV Envelope CD4 binding site (CD4bs) are a major focus of HIV vaccine strategies. While enormous progress has been made in the activation of VRC01-class antibody precursors by immunization
Autor:
Penelope L. Moore, S. S. Abdool Karim, K. Wibmer, Carolyn Williamson, Lynn Morris, Sharon Madzorera, Jinal N. Bhiman, Dale Kitchin, Molati Nonyane, Cathrine Scheepers, Batsirai Mabvakure, Bronwen E. Lambson
Publikováno v:
Virus Evolution
Autor:
Karen P, Coss, Snezana, Vasiljevic, Laura K, Pritchard, Stefanie A, Krumm, Molly, Glaze, Sharon, Madzorera, Penny L, Moore, Max, Crispin, Katie J, Doores
Publikováno v:
Journal of Virology
The HIV envelope glycoprotein (Env) is extensively modified with host-derived N-linked glycans. The high density of glycosylation on the viral spike limits enzymatic processing, resulting in numerous underprocessed oligomannose-type glycans. This ext