Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Sharon M. Sagnella"'
Autor:
Gerard J. Chu, Charles G. Bailey, Rajini Nagarajah, Sharon M. Sagnella, Stephen Adelstein, John E. J. Rasko
Publikováno v:
Cancer Cell International, Vol 23, Iss 1, Pp 1-18 (2023)
Abstract Background Chimeric antigen receptor (CAR) T-cells have revolutionized the treatment of CD19- and B-cell maturation antigen-positive haematological malignancies. However, the effect of a CAR construct on the function of T-cells stimulated vi
Externí odkaz:
https://doaj.org/article/c567b9f811a84470a0eab063b6a318d5
Autor:
Sharon M, Sagnella, Amy L, White, Dannel, Yeo, Payal, Saxena, Nico, van Zandwijk, John E J, Rasko
Publikováno v:
Pharmacological Research. 182:106329
Cellular therapies utilizing T cells expressing chimeric antigen receptors (CARs) have garnered significant interest due to their clinical success in hematological malignancies. Unfortunately, this success has not been replicated in solid tumors, wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b6795d87422fb1190002c5c5bc2ff0a
https://doi.org/10.1016/j.phrs.2022.106329
https://doi.org/10.1016/j.phrs.2022.106329
Autor:
Maria Kavallaris, Xiaoyu Cheng, Stuart B. Lowe, J. Justin Gooding, Xin Chen, Xun Lu, Jason Scott, Alexander H. Soeriyadi, Sharon M. Sagnella
Publikováno v:
Biomaterials science. 2(1)
A silica-based mesoporous nanosphere (MSN) controlled-release drug delivery system has been synthesized and characterized. The system uses L-cysteine derivatized gold nanoparticles (AuNPs), bound to the MSNs using Cu2+ as a bridging ion. The AuNPs se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::795f8a4f5aab7ae3f79cc95b6e0aa1b2
https://pubmed.ncbi.nlm.nih.gov/32481814
https://pubmed.ncbi.nlm.nih.gov/32481814
Autor:
John A. Boockvar, Ebru Boslem, Natasha Vanegas, Gemma E. Stubbs, Katarzyna Smolarczyk, Stephen Clarke, Jennifer A. MacDiarmid, Eva St. Clair, Sharon M. Sagnella, Lu Yang, Himanshu Brahmbhatt, Stacey L. Pattison, Estefania Martino-Echarri
Publikováno v:
Cancer cell. 37(3)
Summary Immunotherapy has emerged as a powerful new chapter in the fight against cancer. However, it has yet to reach its full potential due in part to the complexity of the cancer immune response. We demonstrate that tumor-targeting EDV nanocells fu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95b76974c9a1270c0be273bfe2cb8229
https://pubmed.ncbi.nlm.nih.gov/32183951
https://pubmed.ncbi.nlm.nih.gov/32183951
Autor:
Jennifer Trieu, Andrew J. Gifford, Joshua A. McCarroll, Sharon M. Sagnella, Jennifer A. MacDiarmid, Christopher M. Fife, Renee Whan, David S. Ziegler, Maria Kavallaris, Himanshu Brahmbhatt, Alexander Macmillan
Publikováno v:
Molecular cancer therapeutics. 17(5)
Advanced stage neuroblastoma is an aggressive disease with limited treatment options for patients with drug-resistant tumors. Targeted delivery of chemotherapy for pediatric cancers offers promise to improve treatment efficacy and reduce toxicity ass
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::928dc6a06db245a3d68190918fc23ecf
https://pubmed.ncbi.nlm.nih.gov/29491149
https://pubmed.ncbi.nlm.nih.gov/29491149
Autor:
Alexander H. Soeriyadi, Xun Lu, Sharon M. Sagnella, Maria Kavallaris, Xin Chen, J. Justin Gooding
Publikováno v:
Advanced Functional Materials. 24:6999-7006
Despite the rapid development of drug delivery vehicles that react to a specific biological environment, the complexity of triggering drug release in a particular target area remains an enduring challenge. Here, the engineering of bioresponsive polym
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::41e703028c1916a9940e09cb67ebe048
https://doi.org/10.1002/adfm.201402339
https://doi.org/10.1002/adfm.201402339
Autor:
Maria Kavallaris, Christopher M. Fife, Jonathan P. Wojciechowski, Alexander F. Mason, Pall Thordarson, Sharon M. Sagnella, Adam D. Martin
Publikováno v:
ChemPlusChem. 82(3)
Two peptide-derived low-molecular-weight gelators bearing different capping groups, 9-fluorenylmethyloxycarbonyl (Fmoc) and phenothiazine, were synthesized and their gel networks were characterized. The variation of the N-terminal capping group affec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7adc2605e4436e1495338a0dc4d9721
https://pubmed.ncbi.nlm.nih.gov/31962021
https://pubmed.ncbi.nlm.nih.gov/31962021
Autor:
Joshua A. McCarroll, Phoebe A. Phillips, David Goldstein, George Sharbeen, Cyrille Boyer, Thomas P. Davis, Maria Kavallaris, Hien T. T. Duong, Joann Teo, Jie Liu, Janet Youkhana, Sharon M. Sagnella
Publikováno v:
Biomacromolecules. 17(7)
Pancreatic cancer is a devastating disease with a dismal prognosis. Short-interfering RNA (siRNA)-based therapeutics hold promise for the treatment of cancer. However, development of efficient and safe delivery vehicles for siRNA remains a challenge.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0818922fee70ecc6d3a10caed3962bcb
https://pubmed.ncbi.nlm.nih.gov/27305597
https://pubmed.ncbi.nlm.nih.gov/27305597
Autor:
Minoo J. Moghaddam, Xiaojuan Gong, Lynne J. Waddington, Charlotte E. Conn, Calum J. Drummond, Sharon M. Sagnella, Stephen J. Danon
Publikováno v:
Colloids and Surfaces B: Biointerfaces. 85:349-359
An amphiphile prodrug, 5'-deoxy-5-fluoro-N(4)-(palmityloxycarbonyl) cytidine or 5'-deoxy-5-fluoro-N(4)-(hexadecanaloxycarbonyl) cytidine (5-FCPal), consisting of the same head group as the commercially available chemotherapeutic agent Capecitabine, l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ccd16f30ee35f2f4affe1207d084db0
https://doi.org/10.1016/j.colsurfb.2011.03.007
https://doi.org/10.1016/j.colsurfb.2011.03.007
Autor:
Lynne J. Waddington, Charlotte E. Conn, Xavier Mulet, Nigel Kirby, Minoo J. Moghaddam, Sharon M. Sagnella, Calum J. Drummond, Joseph N. Varghese, Connie Darmanin
Publikováno v:
Soft Matter. 7:567-578
Intrinsic difficulties in characterizing the structure of combined membrane protein–lyotropic liquid crystalline lipidic cubic systems have hampered the development of techniques such as membrane protein (MP) crystallization, which remain largely e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6a1d79f31fe1ed594cc8feb8d91dd6b7
https://doi.org/10.1039/c0sm00790k
https://doi.org/10.1039/c0sm00790k