Zobrazeno 1 - 10
of 94
pro vyhledávání: '"Sharon M. Gorski"'
Autor:
Marie Morimoto, Vikas Bhambhani, Nour Gazzaz, Mariska Davids, Paalini Sathiyaseelan, Ellen F. Macnamara, Jennifer Lange, Anna Lehman, Patricia M. Zerfas, Jennifer L. Murphy, Maria T. Acosta, Camille Wang, Emily Alderman, Undiagnosed Diseases Network, Sara Reichert, Audrey Thurm, David R. Adams, Wendy J. Introne, Sharon M. Gorski, Cornelius F. Boerkoel, William A. Gahl, Cynthia J. Tifft, May Christine V. Malicdan
Publikováno v:
npj Genomic Medicine, Vol 8, Iss 1, Pp 1-16 (2023)
Abstract Autophagy regulates the degradation of damaged organelles and protein aggregates, and is critical for neuronal development, homeostasis, and maintenance, yet few neurodevelopmental disorders have been associated with pathogenic variants in g
Externí odkaz:
https://doaj.org/article/26c827d9dfcc46b4ace723c7df39bf58
Autor:
Kevin C. Yang, Sharon M. Gorski
Publikováno v:
STAR Protocols, Vol 3, Iss 2, Pp 101283- (2022)
Summary: RNA-sequencing and quantitative proteomic profiling simultaneously measure thousands of molecules and provide opportunities to decipher the transcriptomic and proteomic landscapes of cohort specimens for basic and health research. We present
Externí odkaz:
https://doaj.org/article/4fe8dce9ce3b43f1832816ec18e1139e
Autor:
Chandra Lebovitz, Nicole Wretham, Maryam Osooly, Katy Milne, Tia Dash, Shelby Thornton, Basile Tessier-Cloutier, Paalini Sathiyaseelan, Svetlana Bortnik, Nancy Erro Go, Elizabeth Halvorsen, Rachel A. Cederberg, Norman Chow, Nancy Dos Santos, Kevin L. Bennewith, Brad H. Nelson, Marcel B. Bally, Wan L. Lam, Sharon M. Gorski
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Pathological links between neurodegenerative disease and cancer are emerging. LRRK2 overactivity contributes to Parkinson’s disease, whereas our previous analyses of public cancer patient data revealed that decreased LRRK2 expression is as
Externí odkaz:
https://doaj.org/article/a628231eefc547ca89a67c8ce3fcdf31
Autor:
Suganthi Chittaranjan, Jing Xu, Michael Kuzyk, Harpreet K. Dullat, James Wilton, Lindsay DeVorkin, Chandra Lebovitz, Gregg B. Morin, Marco A. Marra, Sharon M. Gorski
Publikováno v:
Biology Open, Vol 4, Iss 5, Pp 672-684 (2015)
TNFAIP8 and other mammalian TIPE family proteins have attracted increased interest due to their associations with disease-related processes including oncogenic transformation, metastasis, and inflammation. The molecular and cellular functions of TIPE
Externí odkaz:
https://doaj.org/article/c8bbb6b85c14421a89d66ffedb04942b
Autor:
Svetlana Bortnik, Sharon M. Gorski
Publikováno v:
International Journal of Molecular Sciences, Vol 18, Iss 7, p 1496 (2017)
Autophagy, a lysosome-mediated intracellular degradation and recycling pathway, plays multiple context-dependent roles in tumorigenesis and treatment resistance. Encouraging results from various preclinical studies have led to the initiation of numer
Externí odkaz:
https://doaj.org/article/bcef7f5bc90f4b0a9604f6c1f17714a8
Autor:
Sharon M. Gorski, Marcel B. Bally, Donald T. Yapp, Karen Gelmon, Sherry A. Weppler, Lindsay DeVorkin, Nancy E. Go, Amy Leung, Namal Abeysundara, Jing Xu, Wieslawa H. Dragowska, Svetlana Bortnik, Suganthi Chittaranjan
Purpose: Triple-negative breast cancers (TNBC) are defined by a lack of expression of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (ERBB2/HER2). Although initially responsive to chemotherapy, most r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d2ccabdd84a4b612d09df84074731e7
https://doi.org/10.1158/1078-0432.c.6522399.v1
https://doi.org/10.1158/1078-0432.c.6522399.v1
Autor:
Sharon M. Gorski, Marcel B. Bally, Donald T. Yapp, Karen Gelmon, Sherry A. Weppler, Lindsay DeVorkin, Nancy E. Go, Amy Leung, Namal Abeysundara, Jing Xu, Wieslawa H. Dragowska, Svetlana Bortnik, Suganthi Chittaranjan
Establishment of saturation levels of BAF for MDA-MB-231, R8, SUM159PT and R75.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b124e795e655db3a96ef0db5d026152
https://doi.org/10.1158/1078-0432.22452174
https://doi.org/10.1158/1078-0432.22452174
Autor:
Sharon M. Gorski, Marcel B. Bally, Donald T. Yapp, Karen Gelmon, Sherry A. Weppler, Lindsay DeVorkin, Nancy E. Go, Amy Leung, Namal Abeysundara, Jing Xu, Wieslawa H. Dragowska, Svetlana Bortnik, Suganthi Chittaranjan
Detailed description of Alamar blue assay, QRT-PCR, transfections, siRNA, western blot analyses, autophagic flux assay, IHC, and associated references.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24dc2cc3de95cbde0223137d80ba7577
https://doi.org/10.1158/1078-0432.22452162.v1
https://doi.org/10.1158/1078-0432.22452162.v1
Autor:
Sharon M. Gorski, Marcel B. Bally, Donald T. Yapp, Karen Gelmon, Sherry A. Weppler, Lindsay DeVorkin, Nancy E. Go, Amy Leung, Namal Abeysundara, Jing Xu, Wieslawa H. Dragowska, Svetlana Bortnik, Suganthi Chittaranjan
Inhibitory activity of anthracyclines and their analogs on sensitive and resistant TNBC cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e21a090916a3c5552b5ec5a4b1d9793
https://doi.org/10.1158/1078-0432.22452159
https://doi.org/10.1158/1078-0432.22452159
Autor:
Sharon M. Gorski, Marcel B. Bally, Donald T. Yapp, Karen Gelmon, Sherry A. Weppler, Lindsay DeVorkin, Nancy E. Go, Amy Leung, Namal Abeysundara, Jing Xu, Wieslawa H. Dragowska, Svetlana Bortnik, Suganthi Chittaranjan
Supplementary Figure legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7df20fbd07f78ab1a3f939ca5ee4a723
https://doi.org/10.1158/1078-0432.22452165.v1
https://doi.org/10.1158/1078-0432.22452165.v1