Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Sharon M. Cawley"'
Autor:
Hélène Thibault, Sharon M. Cawley, Kenneth D. Bloch, Michael J. Raher, Dmitriy N. Atochin, Sarah R Hayton, Marielle Scherrer-Crosbie, John R. Popovich, Baptiste Kurtz, Hannah R. Shakartzi, Paul L. Huang, Emmanuel S. Buys
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 301:H2093-H2101
Insulin resistance (IR) and systemic hypertension are independently associated with heart failure. We reported previously that nitric oxide synthase 3 (NOS3) has a beneficial effect on left ventricular (LV) remodeling and function after pressure-over
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba551292296ea6cd9a243b6b3cc2922a
https://doi.org/10.1152/ajpheart.00744.2010
https://doi.org/10.1152/ajpheart.00744.2010
Autor:
Fumito Ichinose, Sharon M. Cawley, Kenneth D. Bloch, Starsha A. Kolodziej, Peter Brouckaert, Emmanuel S. Buys
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 301:H157-H163
In the heart, nitric oxide (NO) modulates contractile function; however, the mechanisms responsible for this effect are incompletely understood. NO can elicit effects via a variety of mechanisms including S-nitrosylation and stimulation of cGMP synth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e081de71288ff58bc315454247f95a7
https://doi.org/10.1152/ajpheart.01273.2010
https://doi.org/10.1152/ajpheart.01273.2010
Autor:
Stefano Rivella, Aaron W. Mulivor, Samantha Wallner, Mark J. Alexander, Sara Gardenghi, Asya Grinberg, Ravindra Kumar, Robert Li, R. Scott Pearsall, Rajasekhar N.V.S. Suragani, Sharon M Cawley
Publikováno v:
Blood. 123(25)
In β-thalassemia, unequal production of α- and β-globin chains in erythroid precursors causes apoptosis and inhibition of late-stage erythroid differentiation, leading to anemia, ineffective erythropoiesis (IE), and dysregulated iron homeostasis.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18d50cda191cf2849efcceabf11ea910
https://pubmed.ncbi.nlm.nih.gov/24795345
https://pubmed.ncbi.nlm.nih.gov/24795345
Autor:
John D Quisel, Sako Dianne S, Monique V. Davies, Mark J. Alexander, Kathryn W. Underwood, Rajesh Chopra, Ravindra Kumar, Rajasekhar N V S Suragani, Samuel M. Cadena, Jasbir Seehra, R. Scott Pearsall, Kenneth S Loveday, Asya Grinberg, Matthew T. Devine, Robert Li, Dianne C. Mitchell, Sharon M Cawley
Publikováno v:
Nature medicine. 20(4)
Erythropoietin (EPO) stimulates proliferation of early-stage erythrocyte precursors and is widely used for the treatment of chronic anemia. However, several types of EPO-resistant anemia are characterized by defects in late-stage erythropoiesis, whic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6203e3583d1057186dd0539513a25c66
https://pubmed.ncbi.nlm.nih.gov/24658078
https://pubmed.ncbi.nlm.nih.gov/24658078
Autor:
Ion A. Hobai, Helene Thibault, Sharon M. Cawley, Emmanuel S. Buys, Peter Brouckaert, Robrecht Thoonen, Anje Cauwels, Marielle Scherrer-Crosbie, Kristen M. Rauwerdink, Kenneth D. Bloch, Patrick Sips, Jonathan J. Passeri, Fumito Ichinose, Michael J. Raher
Publikováno v:
BMC Pharmacology
Altered cGMP signaling has been implicated in myocardial depression, morbidity, and mortality associated with sepsis. Previous studies, using inhibitors of soluble guanylate cyclase (sGC), suggested that cGMP generated by sGC contributed to the cardi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dfce50c07a4787b286fee27da237009
https://europepmc.org/articles/PMC2724210/
https://europepmc.org/articles/PMC2724210/
Autor:
Ravindra Kumar, Robert Li, Pedro Martinez, Robert Scott Pearsall, Sharon M Cawley, Rajasekhar N.V.S. Suragani
Publikováno v:
Blood. 126:605-605
Introduction: Myelofibrosis (MF) is a clonal stem cell disorder that originates from acquired mutations in the hematopoietic stem cells leading to abnormal kinase signaling, cell proliferation, cytokine expression, and splenomegaly and ultimately bon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::17709eaaf3b61855a40ebe848def9eb5
https://doi.org/10.1182/blood.v126.23.605.605
https://doi.org/10.1182/blood.v126.23.605.605
Autor:
Carolyn L. Sawyer, Kara F. Brunelle, Sharon M Cawley, Albert van der Vliet, Wolfgang R. Dostmann
Publikováno v:
Cellular signalling. 19(5)
Cyclic-3′,5′-guanosine monophosphate (cGMP) mediates the intracellular signaling cascade responsible for the nitric oxide (NO) initiated relaxation of vascular smooth muscle (VSM). However, the temporal dynamics, including the regulation of cGMP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e6cfea881f05127ff73e9db8abd5a39
https://pubmed.ncbi.nlm.nih.gov/17207606
https://pubmed.ncbi.nlm.nih.gov/17207606
Cygnets: in vivo characterization of novel cGMP indicators and in vivo imaging of intracellular cGMP
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 307
The second messenger cyclic guanosine 5'-monophosphate (cGMP) plays a key role in the control and regulation of a steadily increasing number of diverse physiological processes. As the appreciation of the importance of understanding the cGMP signaling
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3b3ffe01ff76b1796884a385bfe30788
https://pubmed.ncbi.nlm.nih.gov/15988053
https://pubmed.ncbi.nlm.nih.gov/15988053
Cygnets: In Vivo Characterization of Novel cGMP Indicators and In Vivo Imaging of Intracellular cGMP
The second messenger cyclic guanosine 5'-monophosphate (cGMP) plays a key role in the control and regulation of a steadily increasing number of diverse physiological processes. As the appreciation of the importance of understanding the cGMP signaling
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2d2643d485e1ea9684b0812a66f042db
https://doi.org/10.1385/1-59259-839-0:027
https://doi.org/10.1385/1-59259-839-0:027
Autor:
Sharon M Cawley, Wolfgang R. Dostmann
Publikováno v:
BMC Pharmacology. 5
Cyclic GMP is accepted to be the critical second messenger responsible for vasodilation of arterial smooth muscle, via the NO/GC/cGMP/PKG pathway. NO has been shown to increase the catalytic activity of the NO-sensitive Guanylate Cyclase (GC) from 20
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca1754969e46c37d6cd5f3d649a727fc
https://doi.org/10.1186/1471-2210-5-s1-p8
https://doi.org/10.1186/1471-2210-5-s1-p8