Dysregulation of Glycerophosphocholines in the Cutaneous Lesion Caused by Leishmania major in Experimental Murine Models

Autor: Adwaita R. Parab, Diane Thomas, Sharon Lostracco-Johnson, Jair L. Siqueira-Neto, James H. McKerrow, Pieter C. Dorrestein, Laura-Isobel McCall

Publikováno v: Pathogens, Vol 10, Iss 5, p 593 (2021)

Cutaneous leishmaniasis (CL) is the most common disease form caused by a Leishmania parasite infection and considered a neglected tropical disease (NTD), affecting 700,000 to 1.2 million new cases per year in the world. Leishmania major is one of sev

Externí odkaz: https://doaj.org/article/c5dc602a072f4fc3bee7b6e86933c2a9

Dysregulation of Glycerophosphocholines in the Cutaneous Lesion Caused by Leishmania major in Experimental Murine Models

Autor: Jair L. Siqueira-Neto, Adwaita R. Parab, Pieter C. Dorrestein, Laura-Isobel McCall, Sharon Lostracco-Johnson, Diane Thomas, James H. McKerrow

Publikováno v: Pathogens
Volume 10
Issue 5
Pathogens, Vol 10, Iss 593, p 593 (2021)

Cutaneous leishmaniasis (CL) is the most common disease form caused by a Leishmania parasite infection and considered a neglected tropical disease (NTD), affecting 700,000 to 1.2 million new cases per year in the world. Leishmania major is one of sev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bece2d84e2c688a76c1d32ffd6b02b3

Mapping of host-parasite-microbiome interactions reveals metabolic determinants of tropism and tolerance in Chagas disease

Autor: C. Woelfel-Monsivais, C. Gosmanov, S. S. Kane, Laura-Isobel McCall, Sharmily Khanam, K. Flores, D. Li, S. E. Hayes, Chaoyi Wu, Danya A. Dean, Ekram Hossain, Yao Zhang, Diane Thomas, Krithivasan Sankaranarayanan, Adwaita R. Parab, Mitchelle Katemauswa, Sharon Lostracco-Johnson

Publikováno v: Science Advances
Science advances, vol 6, iss 30

Chemical cartography of experimental gastrointestinal Chagas disease identifies previously-unknown mechanisms of disease tolerance.
Chagas disease (CD) is a parasitic disease caused by Trypanosoma cruzi protozoa, presenting with cardiomyopathy,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d47fcf53055c9c9908a69ef823d0c5c
https://pubmed.ncbi.nlm.nih.gov/33248705

4-aminopyridyl-based lead compounds targeting CYP51 prevent spontaneous parasite relapse in a chronic model and improve cardiac pathology in an acute model of Trypanosoma cruzi infection

Autor: Alanderson R. Nogueira, Brian M. Suzuki, James H. McKerrow, Mirian Claudia de Souza Pereira, Jair L. Siqueira-Neto, Diane Thomas, Ken Hirata, Sharon Lostracco-Johnson, Tatiana Araújo Silva, Claudia M. Calvet, Liliane Batista de Mesquita, Jun Yong Choi, William R. Roush, Larissa M. Podust, Marcelo Meuser-Batista

Publikováno v: PLoS neglected tropical diseases, vol 11, iss 12
PLoS Neglected Tropical Diseases, Vol 11, Iss 12, p e0006132 (2017)
PLoS Neglected Tropical Diseases

Background Chagas disease, caused by the protozoan Trypanosoma cruzi, is the leading cause of heart failure in Latin America. The clinical treatment of Chagas disease is limited to two 60 year-old drugs, nifurtimox and benznidazole, that have variabl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed322f364c649b41057c68ffe4e8af05
https://escholarship.org/uc/item/2c70x8d8