Critical loss of the balance between Th17 and T regulatory cell populations in pathogenic SIV infection.

Autor: David Favre, Sharon Lederer, Bittoo Kanwar, Zhong-Min Ma, Sean Proll, Zeljka Kasakow, Jeff Mold, Louise Swainson, Jason D Barbour, Carole R Baskin, Robert Palermo, Ivona Pandrea, Christopher J Miller, Michael G Katze, Joseph M McCune

Publikováno v: PLoS Pathogens, Vol 5, Iss 2, p e1000295 (2009)

Chronic immune activation and progression to AIDS are observed after SIV infection in macaques but not in natural host primate species. To better understand this dichotomy, we compared acute pathogenic SIV infection in pigtailed macaques (PTs) to non

Externí odkaz: https://doaj.org/article/f51263d8f52a4f728d90c832970fefa4

The NS1 Protein of the 1918 Pandemic Influenza Virus Blocks Host Interferon and Lipid Metabolism Pathways

Autor: Terrence M. Tumpey, Randy A. Albrecht, Michael G. Katze, Elizabeth Rosenzweig, Sharon Lederer, Sean Proll, Hui Zeng, Adolfo García-Sastre, Rosalind Billharz, Alan G. Goodman, Marcus J. Korth

Publikováno v: Journal of Virology. 83:10557-10570

The “Spanish influenza” of 1918 claimed an unprecedented number of lives, yet the determinants of virulence for this virus are still not fully understood. Here, we used functional genomics and an in vitro human lung epithelial cell infection mode

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b807f234edb756a266e1f315f62c295
https://doi.org/10.1128/jvi.00330-09

Early transcriptional programming links progression to hepatitis C virus-induced severe liver disease in transplant patients

Autor: Anne M. Larson, Robert L. Carithers, Nathan J. Susnow, Kathie-Anne Walters, Nicolas Tchitchek, Arndt Benecke, Matthew M. Yeh, Alexei L. Krasnoselsky, Michael G. Katze, Sean Proll, Deborah L. Diamond, Sharon Lederer, Angela L. Rasmussen, Marcus J. Korth

Publikováno v: Hepatology
Hepatology, Wiley-Blackwell, 2012, 56 (1), pp.17-27. ⟨10.1002/hep.25612⟩
Hepatology, 2012, 56 (1), pp.17-27. ⟨10.1002/hep.25612⟩

International audience; Liver failure resulting from chronic hepatitis C virus (HCV) infection is a major cause for liver transplantation worldwide. Recurrent infection of the graft is universal in HCV patients after transplant and results in a rapid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0c1a062cedd15714b500d273926f68c
https://hal.archives-ouvertes.fr/hal-01544155

Distinct cellular responses differentiating alcohol- and hepatitis C virus-induced liver cirrhosis

Autor: Loreto Boix, Bryan W. Paeper, Sharon Lederer, Sean Proll, Jordi Bruix, Kathie-Anne Walters, Shahar Robinzon, Nelson Fausto, Michael G. Katze

Publikováno v: Europe PubMed Central
Virology Journal
Virology Journal, Vol 3, Iss 1, p 98 (2006)

BackgroundLittle is known at the molecular level concerning the differences and/or similarities between alcohol and hepatitis C virus induced liver disease. Global transcriptional profiling using oligonucleotide microarrays was therefore performed on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db1e379e1c2c130edb882b631221d78a
https://pubmed.ncbi.nlm.nih.gov/17494128

Genomic Analysis Reveals a Potential Role for Cell Cycle Perturbation in HCV-Mediated Apoptosis of Cultured Hepatocytes

Autor: Deborah L. Diamond, Michael G. Katze, Charles M. Rice, Andrew J. Syder, Bryan W. Paeper, Sharon Lederer, Kathie-Anne Walters

Publikováno v: PLoS Pathogens, Vol 5, Iss 1, p e1000269 (2009)
PLoS Pathogens

The mechanisms of liver injury associated with chronic HCV infection, as well as the individual roles of both viral and host factors, are not clearly defined. However, it is becoming increasingly clear that direct cytopathic effects, in addition to i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55f60da4aa3d0cf6b76085d925a3b1c4
https://doi.org/10.1371/journal.ppat.1000269