Výsledky vyhledávání - "Sharon Layfield"

A Chemogenetic Tool that Enables Functional Neural Circuit Analysis

Autor: Sharon Layfield, Ross A. D. Bathgate, Jaspreet K. Bassi, Mariana Rosso Melo, Andrew M. Allen, Hoai Buu Ngo, Stuart J. McDougall, Clément Menuet, Lin Xie, Angela A. Connelly

Publikováno v: Cell Reports
Cell Reports, Elsevier Inc, In press, 32 (11), pp.108139. ⟨10.1016/j.celrep.2020.108139⟩

Chemogenetics enables manipulation of neuronal activity in experimental animals. While providing information about the transduced neuron expressing a ligand-activated molecule, chemogenetics does not provide understanding about the antecedent circuit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a93fded8cb2971750b7661522e765fe
https://doi.org/10.1016/j.celrep.2020.108139

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Minimization of Human Relaxin-3 Leading to High-Affinity Analogues with Increased Selectivity for Relaxin-Family Peptide 3 Receptor (RXFP3) over RXFP1

Autor: Suode Zhang, Philip Ryan, John D. Wade, Ross A. D. Bathgate, Frances Separovic, Martina Kocan, Mohammad Akhter Hossain, Andrew L. Gundlach, Sharon Layfield, Alessia Belgi, Chrishan S. Samuel, Fazel Shabanpoor

Publikováno v: Journal of Medicinal Chemistry. 55:1671-1681

Relaxin-3 is a neuropeptide that is implicated in the regulation of stress responses and memory. The elucidation of its precise physiological role(s) has, however, been hampered by cross-activation of the relaxin-2 receptor, RXFP1, in the brain. The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1640c208218e607a7cca8aa84ded065a
https://doi.org/10.1021/jm201505p

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Design and development of analogues of dimers of insulin-like peptide 3 B-chain as high-affinity antagonists of the RXFP2 receptor

Autor: Sharon Layfield, John D. Wade, Frances Separovic, Ross A. D. Bathgate, Fazel Shabanpoor, Mohammed Akhter Hossain, Suode Zhang, Tania Ferraro, Richard A. Hughes

Publikováno v: Biopolymers. 96:81-87

Insulin-like peptide 3 (INSL3) is one of 10 members of the human relaxin-insulin superfamily of peptides. It is a peptide hormone that is expressed by fetal and postnatal testicular Leydig cells and postnatal ovarian thecal cells. It mediates testicu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4dfd65e8c8ac466ac6eead9d758bfea
https://doi.org/10.1002/bip.21484

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Resolving the Unconventional Mechanisms Underlying RXFP1 and RXFP2 Receptor Function

Autor: Despina E. Ganella, Tania Ferraro, Emma J. Petrie, Ross A. D. Bathgate, Daniel Scott, Chze K. Kong, Brigham J. Hartley, Tracey Wilkinson, Sharon Layfield, Gabrielle E. Callander

Publikováno v: Annals of the New York Academy of Sciences. 1160:67-73

The receptors for relaxin and insulin-like peptide 3 (INSL3) are now well-characterized as the relaxin family peptide (RXFP) receptors RXFP1 and RXFP2, respectively. They are G-protein-coupled receptors (GPCRs) with closest similarity to the glycopro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0a0ea1522798f046d233053876619d4
https://doi.org/10.1111/j.1749-6632.2009.03949.x

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Effect of helix-promoting strategies on the biological activity of novel analogues of the B-chain of INSL3

Autor: John D. Wade, Frances Separovic, Suode Zhang, Ross A. D. Bathgate, Geoffrey W. Tregear, Sharon Layfield, Mohammed Akhter Hossain, Richard A. Hughes, Fazel Shabanpoor

Publikováno v: Amino Acids. 38:121-131

Insulin-like 3 (INSL3) is a novel circulating peptide hormone that is produced by testicular Leydig cells and ovarian thecal and luteal cells. In males, INSL3 is responsible for testicular descent during foetal life and suppresses germ cell apoptosis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b38f9c32b468d22b7ee31828a7501ce
https://doi.org/10.1007/s00726-008-0219-2

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Synthesis, conformation, receptor binding and biological activities of monobiotinylated human insulin-like peptide 3*

Autor: John D. Wade, Ross A. D. Bathgate, Geoffrey W. Tregear, Sharon Layfield, Hideki Tomiyama, Laszlo Otvos, P. Fu, John M. Hutson, Tania Ferraro

Publikováno v: The Journal of Peptide Research. 63:91-98

Biotin-avidin immobilization has been routinely used as a tool to study peptide-receptor and peptide-antibody interactions. Biotinylated peptides can also be employed to localize cells that express the peptides' receptor, and to analyse ligand-recept

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::93f1d8a4cc3522e137abf08d4fb690e3
https://doi.org/10.1111/j.1399-3011.2003.00118.x

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Relaxin-3: Improved Synthesis Strategy and Demonstration of Its High-Affinity Interaction with the Relaxin Receptor LGR7 Both In Vitro and In Vivo

Autor: Chrishan S. Samuel, Angelo Guidolin, Ross A. D. Bathgate, Chongxin Zhao, Nicola F. Hanson, Feng Lin, Stan Bastiras, John D. Wade, Sherie Ma, Laszlo Otvos, Andrew L. Gundlach, Geoffrey W. Tregear, Tania Ferraro, Sharon Layfield, Chris Giannakis

Publikováno v: Biochemistry. 45:1043-1053

Relaxin-3 is a member of the human relaxin peptide family, the gene for which, RLN3, is predominantly expressed in the brain. Mapping studies in the rodent indicate a highly developed network of RLN3, RLN1, and relaxin receptor-expressing cells in th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2141c5b3e51e76e79a5d9c0d028146c
https://doi.org/10.1021/bi052233e

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Splice variants of the relaxin and INSL3 receptors reveal unanticipated molecular complexity

Autor: Colette Chevrier, Deanne Taylor, Christie A. Kelton, Rene Lynn Schweickhardt, Sharon Layfield, Marco Muda, Paolo Martini, Ross A. D. Bathgate, Peter L. Ryan, Tania Ferraro, Chaomei He

Publikováno v: MHR: Basic science of reproductive medicine. 11:591-600

LGR7 and LGR8 are G protein-coupled receptors that belong to the leucine-rich repeat-containing G-protein coupled receptor (LGR) family, including the thyroid-stimulating hormone (TSH), LH and FSH receptors. LGR7 and LGR8 stimulate cAMP production up

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45cafd539ecd70fb1c30cea352901d79
https://doi.org/10.1093/molehr/gah205

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Characterization of the Mouse and Rat Relaxin Receptors

Autor: Hiroki Morita, Geoffrey W. Tregear, Sharon Layfield, Daniel Scott, Ross A. D. Bathgate, Anne Riesewijk

Publikováno v: Annals of the New York Academy of Sciences. 1041:8-12

Rodent models have been used for many years to probe the actions of relaxin. Identification of the orthologs of human leucine-rich repeat-containing g-protein-coupled receptor 7 (LGR7), the relaxin receptor, in mouse and rat will enable characterizat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7f055782c3958cb89bcc69e5f4fbdc3
https://doi.org/10.1196/annals.1282.002

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