Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Sharon L. Ripp"'
Autor:
Michael W. Leach, Leslie G. Lorello, Gregory L. Finch, Sharon L. Ripp, Ahmed M. Shoieb, Shawn P. O'Neil, Jameel Syed, Zaher A. Radi, Matthew S. Thompson, Mazin Derzi
Publikováno v:
Regulatory Toxicology and Pharmacology. 112:104587
Adalimumab, a recombinant fully human monoclonal antibody targeting tumor necrosis factor (TNF), is approved in the United States and Europe to treat various inflammatory and autoimmune indications. Biosimilars are approved biologics highly similar,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b782c4c13b3cd4d270d27d6799df466
https://doi.org/10.1016/j.yrtph.2020.104587
https://doi.org/10.1016/j.yrtph.2020.104587
Autor:
Tina Checchio, Brinda Tammara, Dona Fleishaker, Arnab Mukherjee, Thomas C. Stock, Heather Eng, Sharon L. Ripp
Publikováno v:
Clinical Pharmacology in Drug Development
The dissociated agonists of the glucocorticoid receptor are a novel class of agents in clinical development for rheumatoid arthritis. PF‐04171327 (fosdagrocorat) is a phosphate ester prodrug of PF‐00251802 (dagrocorat), a selective high‐affinit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f687d0ec3dd261b3a1544a19c9269837
https://pubmed.ncbi.nlm.nih.gov/29112329
https://pubmed.ncbi.nlm.nih.gov/29112329
Autor:
Carolyn M. Klinge, Kathleen A. Mattingly, Margarita M. Ivanova, Sharon L. Ripp, Russell A. Prough, Numan Al-Rayyan, Kristy K. Michael Miller
Publikováno v:
Steroids. 78:15-25
Dehydroepiandrosterone (DHEA) levels were reported to associate with increased breast cancer risk in postmenopausal women, but some carcinogen-induced rat mammary tumor studies question this claim. The purpose of this study was to determine how DHEA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::759adbb4517f925de9a6e27e4a4a0336
https://doi.org/10.1016/j.steroids.2012.10.002
https://doi.org/10.1016/j.steroids.2012.10.002
Autor:
Odette A. Fahmi, Sharon L. Ripp
Publikováno v:
Expert Opinion on Drug Metabolism & Toxicology. 6:1399-1416
Drug-drug interactions caused by induction of metabolizing enzymes, particularly CYP3A, can impact the efficacy and safety of co-administered drugs. It is, therefore, important to understand a new compound's potential for enzyme induction and to unde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a9afe2d57602ec6c13baa1ab3a1903b
https://doi.org/10.1517/17425255.2010.516251
https://doi.org/10.1517/17425255.2010.516251
Autor:
James P. Driscoll, Eric B. McElroy, Christopher S. Jones, Matthew Frank Brown, Jonathan L. Doty, William H. Brissette, Sharon L. Ripp, Mark J. Mitton-Fry, Marc I. Smeets, Thomas M. Harris, Kristen A. Trevena, Amy S. Antipas, Jeffrey M. Casavant, Laura Cook Blumberg, David A. Reim, Lawrence A. Reiter, Michael John Munchhof, Sandra P. McCurdy, Andrei Shavnya
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:4069-4072
5-F substitution of an aminothiazole moiety within a series of thrombopoietin receptor agonists leads to potent agents with an improved hepatic safety profile in rodent toxicology studies.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a9b330b187dd9637115bb616439c324
https://doi.org/10.1016/j.bmcl.2010.05.087
https://doi.org/10.1016/j.bmcl.2010.05.087
Autor:
Viola Tamasi, Thomas E. Geoghagen, Russell A. Prough, Ermin Vila, Sharon L. Ripp, Kristy K. Michael Miller
Publikováno v:
Molecular Pharmacology. 73:968-976
Dehydroepiandrosterone (DHEA), a C19 human adrenal steroid, activates peroxisome proliferator-activated receptor alpha (PPARalpha) in vivo but does not ligand-activate PPARalpha in transient transfection experiments. We demonstrate that DHEA regulate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b12526f3360f51e3d534133ad38ba65
https://doi.org/10.1124/mol.107.036780
https://doi.org/10.1124/mol.107.036780
Autor:
Jennifer L. Liras, Sonia M. de Morais, Jessica B. Mills, Odette A. Fahmi, Sharon L. Ripp, Tristan S. Maurer, Kristen A. Trevena
Publikováno v:
Drug Metabolism and Disposition. 34:1742-1748
Cytochrome P4503A4 (CYP3A4) is the principal drug-metabolizing enzyme in human liver. Drug-drug interactions (DDIs) caused by induction of CYP3A4 can result in decreased exposure to coadministered drugs, with potential loss of efficacy. Immortalized
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ddb84a87d43739c63c5b2e5154b8377
https://doi.org/10.1124/dmd.106.010132
https://doi.org/10.1124/dmd.106.010132
Autor:
Edward T. Morgan, Chunja Lee, Po-Yung Cheng, Kristy K. Michael Miller, John Y.L. Chiang, Russell A. Prough, David S. Riddick, Asmeen Jahan, Yoav E. Timsit, Sharon L. Ripp, Anahita Bhathena
Publikováno v:
Drug Metabolism and Disposition. 32:367-375
This article is an invited report of a symposium sponsored by the Division for Drug Metabolism of the American Society for Pharmacology and Experimental Therapeutics held at Experimental Biology 2003 in San Diego, California, April 11-15, 2003. Sever
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7083737921ce6e79ffc466210ca416f1
https://doi.org/10.1124/dmd.32.4.367
https://doi.org/10.1124/dmd.32.4.367
Publikováno v:
Molecular Pharmacology. 64:113-122
Treatment of rats with peroxisome proliferators is known to affect gene expression, including suppression of CYP2C11. The current study examined the mechanism of negative regulation of CYP2C11, comparing the effects of a classic peroxisome proliferat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b35c958c66be985576dfed8f484a038c
https://doi.org/10.1124/mol.64.1.113
https://doi.org/10.1124/mol.64.1.113
Publikováno v:
Archives of Biochemistry and Biophysics. 412:251-258
The cytochrome p450-dependent formation and subsequent interconversion of dehydroepiandrosterone (DHEA) metabolites 7 alpha-hydroxy-DHEA (7 alpha-OH-DHEA), 7 beta-hydroxy-DHEA (7 beta-OH-DHEA), and 7-oxo-DHEA was observed in human, pig, and rat liver
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba8a19d6e0e2dee0f9c5a469db650537
https://doi.org/10.1016/s0003-9861(03)00056-0
https://doi.org/10.1016/s0003-9861(03)00056-0