Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Sharon L. McCoy"'
Autor:
John R. Klune, Sharon L. McCoy, Timothy R. Billiar, Allan Tsung, David A. Geller, Steven H. Hefeneider
Publikováno v:
Shock. 27:364-369
Sepsis resulting from gram-negative bacterial infections is characterized by an excessive inflammatory immune response initiated by exposure of the host innate immune system to either bacteria or bacterial products, primarily lipopolysaccharide (LPS)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87961269c52b8f4922d3dd0b7f91f822
https://doi.org/10.1097/01.shk.0000239773.95280.2c
https://doi.org/10.1097/01.shk.0000239773.95280.2c
Publikováno v:
The Journal of Immunology. 174:3006-3014
TLRs recognize and respond to conserved motifs termed pathogen-associated molecular patterns. TLRs are characterized by an extracellular leucine-rich repeat motif and an intracellular Toll/IL-1R domain. Triggering of TLRs by pathogen-associated molec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d37325226a821ba769afc66cb6061f57
https://doi.org/10.4049/jimmunol.174.5.3006
https://doi.org/10.4049/jimmunol.174.5.3006
Autor:
Robert M. Bennett, Sharon L. McCoy, Frances A. Hausman, Steven H. Hefeneider, Dennis R. Trune, Stephen E. Kurtz
Publikováno v:
Journal of Biological Chemistry. 279:17217-17223
Bacterial DNA containing unmethylated CpG motifs is a pathogen-associated molecular pattern (PAMP) that interacts with host immune cells via a toll-like receptor (TLR) to induce immune responses. DNA binding and internalization into cells is independ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7490ae7c1319a92aee0882f5deb6abf3
https://doi.org/10.1074/jbc.m303837200
https://doi.org/10.1074/jbc.m303837200
Autor:
Sharon L. McCoy, T. Dan Bracken, Arthur S. Hall, Frances A. Hausman, Steven H. Hefeneider, Nancy Perrin, Diana Takahashi, K.Y. Shin, Heidi L. Christensen
Publikováno v:
Bioelectromagnetics. 22:170-177
This study was designed to assess the effect of exposure to long-term extremely low-frequency electric and magnetic fields (ELF–EMF) from a 500 kV transmission line on IL-1 and IL-2 activity in sheep. The primary hypothesis was that the reduction i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75b09a38172c85646291116fe5df0352
https://doi.org/10.1002/bem.35
https://doi.org/10.1002/bem.35
Autor:
Louise S. Merkens, Antony C. Bakke, Frances A. Hausman, Steven H. Hefeneider, Mark E. Deffebach, Robert M. Bennett, Sharon L. McCoy
Publikováno v:
Journal of Immunological Methods. 241:141-146
DNA binding to cell-surfaces has been documented in several studies. The interaction of DNA with cells has been shown to have therapeutic potential as a non-viral form of gene delivery and DNA vaccination. Recently, bacterial DNA binding and internal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20260a47380d2a3d3d51a5365cc3fcd9
https://doi.org/10.1016/s0022-1759(00)00205-2
https://doi.org/10.1016/s0022-1759(00)00205-2
Autor:
Sharon L. McCoy, Kenneth A. Cornell, Robert M. Bennett, Steven H. Hefeneider, Antony C. Bakke, Lisa E. Brown
Publikováno v:
Autoimmunity. 15:187-194
DNA binds to cell-surface proteins on human and murine leukocytes and induces secretion of the cytokine interleukin 6 (IL-6). Cell-surface DNA binding molecules have been shown to serve as target antigens for the production of autoantibodies in patie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1c3552a65f0752ad80154c95c3cbe49
https://doi.org/10.3109/08916939309019926
https://doi.org/10.3109/08916939309019926
Autor:
J. Beth Kempton, Sarah K. Parrish, Steven H. Hefeneider, Sharon L. McCoy, Carol J. MacArthur, Dennis R. Trune
Publikováno v:
Hearing research. 219(1-2)
Various animal models have been employed for otitis media research. The mouse has been studied less, in spite of its many advantages. To better understand the suitability of the mouse for studies of otitis media, an evaluation was made of its middle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d0b6307723976fb14d4ced3d948be1a
https://pubmed.ncbi.nlm.nih.gov/16887307
https://pubmed.ncbi.nlm.nih.gov/16887307
Publikováno v:
Otologyneurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology. 25(3)
Autoimmune diseased mice with hearing loss will have autoantibodies against the various cochlear antigens proposed in clinical autoimmune inner ear disease.Serum antibodies of patients with hearing loss recognize several proteins that are proposed as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fcb03938196ff8f943832b7f8921c4b
https://pubmed.ncbi.nlm.nih.gov/15129101
https://pubmed.ncbi.nlm.nih.gov/15129101
Publikováno v:
The Journal of Immunology. 178:S150-S151
Sepsis resulting from gram-negative bacterial infections is characterized by an excessive inflammatory immune response initiated by exposure of the host innate immune system to either bacteria or bacterial products, primarily LPS. Engagement of the T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::efac12995e6e32020101ae6948a71b4b
https://doi.org/10.4049/jimmunol.178.supp.89.12
https://doi.org/10.4049/jimmunol.178.supp.89.12
Autor:
Steven H. Hefeneider, Robert M. Bennett, Sharon L. McCoy, Kenneth A. Cornell, Lisa E. Brown, Antony C. Bakke
Publikováno v:
Clinical immunology and immunopathology. 63(3)
The molecular basis for the cellular interaction of DNA and nucleosomes and the physiological consequences of this binding were examined. Both DNA and nucleosomes were demonstrated to bind specifically to the surface of human peripheral blood mononuc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8e5293952ad75018c5bfcfbc405db70
https://pubmed.ncbi.nlm.nih.gov/1623645
https://pubmed.ncbi.nlm.nih.gov/1623645