Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Sharon L. Cheatham"'
Autor:
Kevin M. Flanigan, Tatyana A. Vetter, Tabatha R. Simmons, Megan Iammarino, Emma C. Frair, Federica Rinaldi, Louis G. Chicoine, Johan Harris, John P. Cheatham, Sharon L. Cheatham, Brian Boe, Megan A. Waldrop, Deborah A. Zygmunt, Davin Packer, Paul T. Martin
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 27, Iss , Pp 47-60 (2022)
In a phase 1/2, open-label dose escalation trial, we delivered rAAVrh74.MCK.GALGT2 (also B4GALNT2) bilaterally to the legs of two boys with Duchenne muscular dystrophy using intravascular limb infusion. Subject 1 (age 8.9 years at dosing) received 2.
Externí odkaz:
https://doaj.org/article/5d4cb4d3fc0f4849bd3ccf973f1e61e1
Autor:
Rui Xu, Ying Jia, Deborah A. Zygmunt, Megan L. Cramer, Kelly E. Crowe, Guohong Shao, Agatha E. Maki, Haley N. Guggenheim, Benjamin C. Hood, Danielle A. Griffin, Ellyn Peterson, Brad Bolon, John P. Cheatham, Sharon L. Cheatham, Kevin M. Flanigan, Louise R. Rodino-Klapac, Louis G. Chicoine, Paul T. Martin
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 10, Iss , Pp 89-104 (2018)
Recombinant adeno-associated virus (rAAV)rh74.MCK.GALGT2 is a muscle-specific gene therapy that is being developed to treat forms of muscular dystrophy. Here we report on an isolated limb infusion technique in a non-human primate model, where hindlim
Externí odkaz:
https://doaj.org/article/f9bc6cfb8158407cb2dff2b604340149
Autor:
Carl H. Backes, Sharon L. Cheatham, Grace M. Deyo, Scott Leopold, Molly K. Ball, Charles V. Smith, Vidu Garg, Ralf J. Holzer, John P. Cheatham, Darren P. Berman
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 5, Iss 2 (2016)
BackgroundPercutaneous closure of patent ductus arteriosus (PDA) in term neonates is established, but data regarding outcomes in infants born very preterm (
Externí odkaz:
https://doaj.org/article/97ffc44ed5034adda8c16388b489d3e9
Autor:
Kevin M, Flanigan, Tatyana A, Vetter, Tabatha R, Simmons, Megan, Iammarino, Emma C, Frair, Federica, Rinaldi, Louis G, Chicoine, Johan, Harris, John P, Cheatham, Sharon L, Cheatham, Brian, Boe, Megan A, Waldrop, Deborah A, Zygmunt, Davin, Packer, Paul T, Martin
Publikováno v:
Molecular therapy. Methodsclinical development. 27
In a phase 1/2, open-label dose escalation trial, we delivered rAAVrh74.MCK.
Autor:
Sarah Lewis, Ellyn Peterson, Darren A. Murrey, Lindsay N. Alfano, Louis G. Chicoine, Danielle A. Griffin, Zarife Sahenk, Louise R. Rodino-Klapac, Linda Lowes, Sharon L. Cheatham, Mark J. Hogan, Beverly Galliers, Kelly J. Lehman, Kathleen Church, N. Miller, John P. Cheatham, Samiah Al-Zaidy, Jerry R. Mendell
Publikováno v:
Human Gene Therapy. 30:794-801
In a previous limb-girdle muscular dystrophy type 2D (LGMD2D) clinical trial, robust alpha-sarcoglycan gene expression was confirmed following intramuscular gene (SGCA) transfer. This paved the way for first-in-human isolated limb infusion (ILI) gene
Treatment of caudal cavoatrial junction obstruction in a dog with a balloon-expandable biliary stent
Autor:
D. Berman, M. Rohrbaugh, Sharon L. Cheatham, Karsten E. Schober, John D. Bonagura, Jaylyn D. Rhinehart
Publikováno v:
Journal of Veterinary Cardiology. 23:112-121
A 2-year-old intact female mixed breed dog was presented for ascites. Echocardiography demonstrated severe obstruction at the level of the caudal right atrium. Initially, a variant of cor triatriatum dexter was diagnosed, and balloon catheter dilatio
Autor:
Sharon L. Cheatham, Joanne L. Chisolm, Brian A. Boe, John P. Cheatham, Aimee K. Armstrong, Darren P. Berman
Publikováno v:
Congenital Heart Disease. 14:297-304
Objective We sought to describe the leaflet morphology variation in the Melody Transcatheter Pulmonary Valve (TPV) and evaluate associated outcomes. The Melody TPV is constructed from harvested bovine jugular venous valves which have been rigorously
Autor:
Sarah Janse, Darren P. Berman, Katie Stockmaster, Emefah Loccoh, Sharon L. Cheatham, Aimee K. Armstrong, Brian A. Boe, Ralf J. Holzer, John P. Cheatham
Publikováno v:
Circulation. Cardiovascular interventions. 14(2)
Background: Stent implantation (SI) is more effective than balloon angioplasty for the treatment of coarctation of the aorta (CoA). Due to technical factors, balloon angioplasty is more commonly performed in small patients. We sought to evaluate outc
Autor:
Brad Bolon, Agatha E. Maki, Ellyn Peterson, Louise R. Rodino-Klapac, Megan L. Cramer, Kevin M. Flanigan, Rui Xu, Haley N. Guggenheim, Louis G. Chicoine, Kelly E. Crowe, Deborah A. Zygmunt, Benjamin C. Hood, John P. Cheatham, Ying Jia, Danielle A. Griffin, Sharon L. Cheatham, Guohong Shao, Paul T. Martin
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 10, Iss, Pp 89-104 (2018)
Recombinant adeno-associated virus (rAAV)rh74.MCK.GALGT2 is a muscle-specific gene therapy that is being developed to treat forms of muscular dystrophy. Here we report on an isolated limb infusion technique in a non-human primate model, where hindlim
Autor:
Evan M. Zahn, Tal Geva, Matthew J. Gillespie, Lee N. Benson, John P. Cheatham, John E. Mayer, Kan N Hor, Andrew J. Powell, Thomas K. Jones, Mark Osten, Brian T. McHenry, Sharon L. Cheatham, Peter Ewert, Lisa Bergersen, Andreas Eicken, William E. Hellenbrand, Eric Horlick, Andrew M. Crean, Emile A. Bacha
Publikováno v:
The American Journal of Cardiology. 120:1387-1392
This early feasibility study was designed to obtain in vivo data to confirm assumptions on device loading conditions of the Medtronic Harmony transcatheter pulmonary valve (TPV). Secondary objectives included procedural feasibility, safety, and valve