Zobrazeno 1 - 10 of 40 pro vyhledávání: '"Sharon L Longo"'
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Akademický článek
The extracellular matrix protein fibulin-3/EFEMP1 promotes pleural mesothelioma growth by activation of PI3K/Akt signaling
Autor: Arivazhagan Roshini, Chandra Goparaju, Somanath Kundu, Mohan S. Nandhu, Sharon L. Longo, John A. Longo, Joan Chou, Frank A. Middleton, Harvey I. Pass, Mariano S. Viapiano
Publikováno v: Frontiers in Oncology, Vol 12 (2022)
Malignant pleural mesothelioma (MPM) is an aggressive tumor with poor prognosis and limited therapeutic options. The extracellular matrix protein fibulin-3/EFEMP1 accumulates in the pleural effusions of MPM patients and has been proposed as a prognos
Externí odkaz: https://doaj.org/article/c736b5add55d420e9368c5a76b3b2039
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The scaffolding protein DLG5 promotes glioblastoma growth by controlling Sonic Hedgehog signaling in tumor stem cells
Autor: Somanath Kundu, Mohan S Nandhu, Sharon L Longo, John A Longo, Shawn Rai, Lawrence S Chin, Timothy E Richardson, Mariano S Viapiano
Publikováno v: Neuro Oncol
Background Tumor invasion, a hallmark of malignant gliomas, involves reorganization of cell polarity and changes in the expression and distribution of scaffolding proteins associated with polarity complexes. The scaffolding proteins of the DLG family
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ee1d963e2f0656a4a15ba0626a9d657
https://doi.org/10.1093/neuonc/noac001
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Figures S1 to S8 from Development of a Function-Blocking Antibody Against Fibulin-3 as a Targeted Reagent for Glioblastoma
Autor: Mariano S. Viapiano, E. Antonio Chiocca, Diego J. Rodriguez-Gil, Sadhak Sengupta, Lina M. Barrera-Arenas, Sharon L. Longo, Vivek Bhaskaran, Prajna Behera, Mohan S. Nandhu
Figure S1: Generation of mAb428.2 antibody; Figure S2: Affinity of mAb428.2 for fibulin-3; Figure S3: mAb428.2 binds to cell-surface and interstitial fibulin-3; Figure S4: mAb428.2 does not cause acute toxicity; Figure S5: Locally-delivered mAb428.2
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48dc2f9a3e5578f8da0db8a9ecc24189
https://doi.org/10.1158/1078-0432.22464192
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Ko143 Reverses MDR in Glioblastoma
Autor: Samuel D, Lustig, Sravan K, Kodali, Sharon L, Longo, Somanath, Kundu, Mariano S, Viapiano
Publikováno v: Anticancer research. 42(2)
Over-expression of both P-glycoprotein (P-gp) and Breast Cancer Resistance Protein (BCRP) has been associated with multidrug-resistance in glioblastoma (GBM). Though previously studied broad-spectrum inhibitors of drug efflux pumps have failed to pro
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6a1cb3247a2d1b533f2dbef791063c5d
https://pubmed.ncbi.nlm.nih.gov/35093870
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Abstract 3167: The scaffolding protein DLG5 is necessary to maintain Sonic Hedgehog signaling in glioblastoma stem cells and promote tumor growth
Autor: Somanath Kundu, Mohan S. Nandhu, Sharon L. Longo, John A. Longo, Shawn Rai, Lawrence S. Chin, Timothy E. Richardson, Mariano S. Viapiano
Publikováno v: Cancer Research. 82:3167-3167
Proteins complexes that maintain the apico-basal polarity of epithelial cells and organize cell-signaling domains are necessary for normal tissue organization and therefore regarded as tumor suppressors. Accordingly, the scaffolding proteins that for
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::840f510840b15cf1518ac544ac44a344
https://doi.org/10.1158/1538-7445.am2022-3167
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Brain repair by hematopoietic growth factors in the subacute phase of traumatic brain injury
Autor: Gentian, Toshkezi, Michele, Kyle, Sharon L, Longo, Lawrence S, Chin, Li-Ru, Zhao
Publikováno v: Journal of Neurosurgery. 129:1286-1294
OBJECTIVETraumatic brain injury (TBI) is a major cause of long-term disability and death in young adults. The lack of pharmaceutical therapy for post–acute TBI recovery remains a crucial medical challenge. Stem cell factor (SCF) and granulocyte col
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89e1944fa347289851e67ba483dba070
https://doi.org/10.3171/2017.7.jns17878
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Chromatin run-on and sequencing maps the transcriptional regulatory landscape of glioblastoma multiforme
Autor: Tinyi Chu, Gregory T. Booth, H. Hans Salamanca, John T. Lis, Leighton J. Core, Robert John Corona, Charles G. Danko, Sharon L. Longo, Zhong Wang, Hojoong Kwak, Edward J. Rice, Lawrence S. Chin
Publikováno v: Nature genetics
The human genome encodes a variety of poorly understood RNA species that remain challenging to identify using existing genomic tools. We developed chromatin run-on and sequencing (ChRO-seq) to map the location of RNA polymerase for almost any input s
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7f382d524229b11dc9834d8ca8fdcb9
http://europepmc.org/articles/PMC6204104
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