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Akademický článek

MMP9 inhibition increases erythropoiesis in RPS14-deficient del(5q) MDS models through suppression of TGF-β pathways

Autor: Minyoung Youn, Haigen Huang, Cheng Chen, Sharon Kam, Mark C. Wilkes, Hee-Don Chae, Kunju J. Sridhar, Peter L. Greenberg, Bertil Glader, Anupama Narla, Shuo Lin, Kathleen M. Sakamoto

Publikováno v: Blood Advances, Vol 3, Iss 18, Pp 2751-2763 (2019)

The del(5q) myelodysplastic syndrome (MDS) is a distinct subtype of MDS, associated with deletion of the ribosomal protein S14 (RPS14) gene that results in macrocytic anemia. This study sought to identify novel targets for the treatment of patients w

Externí odkaz: https://doaj.org/article/f293d06ad8ca4576845be250edd62e69

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Akademický článek

Loss of Forkhead box M1 promotes erythropoiesis through increased proliferation of erythroid progenitors

Autor: Minyoung Youn, Nan Wang, Corinne LaVasseur, Elena Bibikova, Sharon Kam, Bertil Glader, Kathleen M. Sakamoto, Anupama Narla

Publikováno v: Haematologica, Vol 102, Iss 5 (2017)

Forkhead box M1 (FOXM1) belongs to the forkhead/winged-helix family of transcription factors and regulates a network of proliferation-associated genes. Its abnormal upregulation has been shown to be a key driver of cancer progression and an initiatin

Externí odkaz: https://doaj.org/article/fdd8dab1df564e489fc0f081d50c1a40

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Improving annual albuminuria testing for individuals with diabetes

Autor: Sharon Kam, Santiago Angaramo, Jacqueline Antoun, Manasa R Bhatta, Pauleatha Diggs Bonds, Adrian G Cadar, Valentine U Chukwuma, Patrick J Donegan, Zachary Feldman, Alan Z Grusky, Veerain K Gupta, Jeremy B Hatcher, Jaclyn Lee, Natalia G Morales, Erin N Vrana, Bronson C Wessinger, Michael Z Zhang, Michael J Fowler, Chase D Hendrickson

Publikováno v: BMJ Open Quality
BMJ Open Quality, Vol 11, Iss 1 (2022)

BackgroundAnnual albuminuria screening detects the early stages of nephropathy in individuals with diabetes. Because early detection of albuminuria allows for interventions that lower the risk of developing chronic kidney disease, guidelines recommen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adcf01dd40eb6dbc3c984b97ec6a10dd
https://pubmed.ncbi.nlm.nih.gov/35101868

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SAR optimization studies on modified salicylamides as a potential treatment for acute myeloid leukemia through inhibition of the CREB pathway

Autor: Samanta Capolicchio, Tae-León Butler, Mark Smith, Sharon Kam, Jeffrey Edwards, Kathleen M. Sakamoto, Soichi Wakatsuki, Garrett Potter, Hee-Don Chae, Justin Chan, Jae Wook Lee, Corey W. Liu, Mark C. Capece, Naoki Horikoshi, Yvonne Lee, Andrew A. Ng, Nick Cox

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 29:2307-2315

Disruption of cyclic adenosine monophosphate response element binding protein (CREB) provides a potential new strategy to address acute leukemia, a disease associated with poor prognosis, and for which conventional treatment options often carry a sig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6c0f70ed2a700fe080eda3903e50ec2
https://doi.org/10.1016/j.bmcl.2019.06.023

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